Navigation Links
When inflexibility is counterproductive: Mechanism of UV-induced DNA Dewar lesion revealed
Date:11/28/2011

Excessive exposure to ultraviolet (UV) radiation of sunlight can result in skin damage and may even induce skin cancers. Irradiation with UV light causes mutations in the DNA, which can interfere with or even inhibit the read-out of genetic information and hence affect the cell function. The Dewar lesion is one of the major UV-induced reaction products, which can itself generate mutations. Understanding the mechanism that leads to the formation of the Dewar lesion is therefore of great interest.Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have now shown that the DNA backbone (the double-stranded scaffold which bears the subunits that encode the genetic information) plays a decisive role in the process. The Dewar lesion can be generated only if the backbone of the DNA is intact. If the DNA strand itself is broken, and therefore more flexible, the Dewar reaction will not take place. The process reveals a surprisingly paradoxical facet of the DNA structure. On the one hand, an unbroken backbone is a prerequisite for DNA function and for cell survival; on the other, the intact backbone favors the formation of Dewar lesions upon exposure to UV, and so facilitates UV-induced mutagenesis. (Angewandte Chemie, 23 November 2011)

UV radiation induces molecular changes in DNA structure, which can lead to genetic mutations and finally to cell death. Energetic UV light primarily produces two types of photochemical damage in the subunits of the DNA - cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts. Both types of lesion are due to cross-linking of adjacent pyrimidine bases on the same DNA strand. Continued exposure to UV light transforms the (6-4) photoproduct into a Dewar lesion by inducing further structural changes. Dewar lesions are stable end-products of continuous exposure to sunlight. Moreover, they are highly mutagenic, i.e. they can themselves induce a range of further mutations. "While the chemical changes that give
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Conaway Lab identifies novel mechanism for regulation of gene expression
2. Rong Li Lab probes mechanism of asymmetry in meiotic cell division
3. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
4. Scientists unveil mechanism for up and down in plants
5. New cell division mechanism discovered
6. Corn researchers discover novel gene shut-off mechanisms
7. New regulatory mechanism discovered for cell identify and behavior in forming organs
8. Biomedical engineers detective work reveals antibiotic mechanism
9. Mechanisms of cardiovascular disease and cancer give clues to new therapies
10. Argonne scientists discover possible mechanism for creating handedness in biological molecules
11. A little wine boosts omega-3 in the body: Researchers find a novel mechanism for a healthier heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Calif. , Dec. 18, 2014  23andMe, Inc., the leading ... that pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred years ago, ... a meeting place for peoples from different continents. This study ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... with foot and mouth disease could very well spread the ... Proceedings of the Royal Society B , Lawrence Livermore National ... be a source of infectious foot and mouth disease virus ... and mouth disease virus is found in skin and that ...
... release is available in French and German ... practical and therefore very popular. In terms of their environmental ... Hischier, Empa,s ecobalance expert, has just finished investigating various capsule ... coffee making techniques, and has prepared a simplified life cycle ...
... a new polarimeter, a basic scientific instrument used to ... as light waves, that could prove useful in determining ... device. Certain compounds differ only in the ... light is light whose electric vector moves back and ...
Cached Biology News:Foot and mouth disease may spread through shedding skin cells 2It all depends on the coffee 2It all depends on the coffee 3Chemistry researchers receive patent for new scientific measurement instrument 2
(Date:1/22/2015)... January 22, 2015 zFlo Motion , ... to announce an exciting product from a new partner. ... solutions over the past 15 years, with offerings in the ... their 3D IMU system (inertial measurement unit), iSen, is opening ...
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Diagenode, ... such as the Bioruptor® and complete solutions for ... for chromatin immunoprecipitation, alleviating the need for manual ... controls needed for ChIP of histones or transcription ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... May 27 Cord Blood America, Inc. (OTC Bulletin Board: ... http://www.cordblood-america.com ) focused on bringing ... and internationally, said today that it has reduced its secured ... five months of 2009. "On April 6th, 2009, Cord ...
... certain marginalized groups including the mentally ill, the ... Latinos fare worse than others in the aftermath ... , Now, a new study by ... experience greater terrorism-related fears and make more behavioral changes ...
... Aviv University a network of tiny sensors as small ... most determined intruder. Scattered outdoors on rocks, fence posts ... the dewdrops are a completely new and cost-effective system for ... Shapira and his Tel Aviv University Faculty of Engineering team ...
Cached Biology Technology:Cord Blood America Says Debt Reduced $4.194 Million in 2009 2Disabled and other vulnerable groups more susceptible to terrorism fears 2Intruder alert: Tel Aviv University's 'Smart Dew' will find you! 2
Human PDGF R beta MAb (Clone # PR7212)...
Recombinant Mouse IL-23, CF...
Rabbit Serum New Zealand or California Origin...
Collected from 8-12 week old New Zealand or Californian rabbits. Aseptically collected and processed to minimize hemolytic activity. Pricing: $60/unit for 1 - 10 units...
Biology Products: