Navigation Links
When cells go bad
Date:9/30/2008

called "checkpoint" proteins named Chk1 and Chk2 are required for the suicide of fruit fly cells with a missing telomere.

They also found that a non-mutant cell lacking a telomere occasionally escapes suicide and divides. Then, its progeny accumulate defects, including the wrong number of chromosomes or chromosomes that have exchanged pieces with each other. Those defects are hallmarks of cancer cells.

One possible reason a cell avoids suicide even after telomere loss and other damage is that chromosomes in the cell's offspring regain telomeres.

"All cancer cells have figured out how to add new telomeres, which allows them to survive and divide indefinitely," says Titen. "By interfering with this process, it might be possible to provide a route therapeutically to treat cancer."

A telomere is made of short sequences of DNA repeated hundreds of times. Proteins bind to the DNA, forming a cap or telomere that protects the end of the chromosome.

In humans, cells in certain tissues, such as the skin, continue to divide over a lifetime. Each time a cell divides, the telomeres become shorter until, in rare cases, the rest of the chromosome is no longer protected. It has been proposed that this can trigger cancer, but previous studies have been done only in yeast or cultured animal cells that are grown in a dish. The new Utah study shows in flies that telomere loss can cause cancer-like changes in a cell.

When Cell Suicide is Blocked, Cells Start on the Road to Cancer

Fruit flies often are used for chromosomal studies because they share 60 percent of their genes with humans, and it is unethical to cause genetic abnormalities in humans. Also, the process by which fly cells grow and divide are comparable with human cells.

To trigger telomere loss, the researchers inserted into the flies a gene from common baker's yeast. The gene makes an enzyme that breaks and rejoins DNA. When they tur
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NSF funds new Center for the Physics of Living Cells at Illinois
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
4. St. Jude study gives new insights into how cells accessorize their proteins
5. UNC scientists turn human skin cells into insulin-producing cells
6. Colorful spy tactics track live cells supporting cancerous tumors
7. Flatworm helps researchers study stem cells and cancer
8. Viral magic bullet targets cancer cells with help of new compound
9. Stem cells may solve mystery of early pregnancy breast cancer protection
10. Embryonic stem cells might help reduce transplantation rejection
11. Scientists isolate cancer stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
When cells go bad
(Date:8/1/2014)... at The Scripps Research Institute (TSRI) have identified a ... in brown fat cells. , The study, which ... the Proceedings of the National Academy of Sciences ... fat thermogenesis," which is of great interest to medical ... also protect against diabetes. , "This finding offers new ...
(Date:7/31/2014)... In the United States, natural-gas production from shale ... since 2007. Yet scientists still do not fully ... according to a report in the journal ... As gas extraction continues to vastly outpace scientific ... various organizations and institutions, including Princeton University, concluded ...
(Date:7/31/2014)... Fla. --- By tracing nearly 3,000 genes to ... University of Florida scientists have created an extensive ... use large-scale, next-generation DNA sequencing. , Among ... closely related to small moths than to large ... butterflies evolved. The study also found that some ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3
... Knut Stamnes, Professor and Department Director of Physics ... has been awarded a NASA grant for work ... satellite. His proposal to "use and further develop ... coupled atmosphere-surface systems" is funded as part of ...
... Senior Design team at Stevens Institute of Technology is ... arise during thoracic surgeries. Five undergraduate Biomedical Engineering students ... of existing catheter design and introduces a potentially profitable ... the efforts of the Stevens Innovative Fluid Extraction System ...
... revealing how age-old irrigation techniques may have boosted the ... an estimated 200 million people today. ... kingdom that was located in present-day Sudan, provides details ... disease across populations in ancient times, and how human ...
Cached Biology News:Dr. Knut Stamnes at Stevens receives NASA grant for environmental monitoring 2Dr. Knut Stamnes at Stevens receives NASA grant for environmental monitoring 3Stevens thoracic catheter senior design team takes 1st place at regional ISPE competition 2Stevens thoracic catheter senior design team takes 1st place at regional ISPE competition 3Mummies tell history of a 'modern' plague 2Mummies tell history of a 'modern' plague 3
(Date:8/1/2014)... Corporation (NYSE: CBM ) reports results for the ... , Second quarter sales increased 59% to $98.0 ... , Second quarter EBITDA increased 86% to $21.2 million ... (see table at the end of this release). , ... foreign currency, to between 13% and 16% over 2013, and ...
(Date:7/31/2014)... Dallas, Texas (PRWEB) August 01, 2014 ... Global and China Polyurethane Resin Industry” is ... Polyurethane Resin market. The report introduces Polyurethane ... application, and industry chain structure and industry ... analysis, including China’s domestic market as well ...
(Date:7/31/2014)... the British mathematician (1912-1954), is famous for a number ... century. In 1936 he published a paper, which laid ... concept of a computer algorithm. He next played a ... machines which cracked the German military codes, enabling the ... And in the late 1940,s he turned his attention ...
(Date:7/31/2014)... , July 31, 2014 The ... today with $25,000 to fund a translational research ... in 2011, the gift was presented at the ... Annual Meeting in Colorado Springs, CO. ... in neurointerventional approaches to neurovascular conditions, SNIS formed ...
Breaking Biology Technology:Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3
... individuals are invited to enter the 35th ... benefits coming from research and engineering of new ... Products Awards are given in four major categories: ... (500-999 employees); medium companies (50-499 employees); and small ...
... gave about $400,000 worth of software to ... youth and their families. Rob Busch, enterprise sales manager ... at the non-profit's Synergy School in Milwaukee for the ... to upgrade Lad Lakes network and software infrastructure, including ...
... Wis. If Wisconsin is to attract the ... it first has to focus on its own environment, ... Biotechnology and Medical-Devices Association. , ,Part of building the ... large corporations, said WBMA President and EraGen CEO Irene ...
Cached Biology Technology:Panel stresses drawing outside biotech firms to state 2
... in permanent mounting media. It is ... immunohistochemical organic insoluble substrates such as ... and any other organic solvent compatible ... can be used for histology and ...
... The Gene Inspector can perform many sophisticated ... software is much more than just another sequence ... an entire suite of analyses to be performed ... to design custom style sheets which specify exactly ...
... through columns is a well-known separation technique ... applications are in DNA/RNA extraction in microbiology, ... purification in chemical or analytical laboratories. ... Genesis series instruments for smaller scales. The ...
... a revolutionary new application for DNA ... novel interface, Expression makes complex computational ... Expression uses the very latest computing ... the way sequences are analysed. Features ...
Biology Products: