Navigation Links
When cells go bad
Date:9/30/2008

called "checkpoint" proteins named Chk1 and Chk2 are required for the suicide of fruit fly cells with a missing telomere.

They also found that a non-mutant cell lacking a telomere occasionally escapes suicide and divides. Then, its progeny accumulate defects, including the wrong number of chromosomes or chromosomes that have exchanged pieces with each other. Those defects are hallmarks of cancer cells.

One possible reason a cell avoids suicide even after telomere loss and other damage is that chromosomes in the cell's offspring regain telomeres.

"All cancer cells have figured out how to add new telomeres, which allows them to survive and divide indefinitely," says Titen. "By interfering with this process, it might be possible to provide a route therapeutically to treat cancer."

A telomere is made of short sequences of DNA repeated hundreds of times. Proteins bind to the DNA, forming a cap or telomere that protects the end of the chromosome.

In humans, cells in certain tissues, such as the skin, continue to divide over a lifetime. Each time a cell divides, the telomeres become shorter until, in rare cases, the rest of the chromosome is no longer protected. It has been proposed that this can trigger cancer, but previous studies have been done only in yeast or cultured animal cells that are grown in a dish. The new Utah study shows in flies that telomere loss can cause cancer-like changes in a cell.

When Cell Suicide is Blocked, Cells Start on the Road to Cancer

Fruit flies often are used for chromosomal studies because they share 60 percent of their genes with humans, and it is unethical to cause genetic abnormalities in humans. Also, the process by which fly cells grow and divide are comparable with human cells.

To trigger telomere loss, the researchers inserted into the flies a gene from common baker's yeast. The gene makes an enzyme that breaks and rejoins DNA. When they tur
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NSF funds new Center for the Physics of Living Cells at Illinois
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
4. St. Jude study gives new insights into how cells accessorize their proteins
5. UNC scientists turn human skin cells into insulin-producing cells
6. Colorful spy tactics track live cells supporting cancerous tumors
7. Flatworm helps researchers study stem cells and cancer
8. Viral magic bullet targets cancer cells with help of new compound
9. Stem cells may solve mystery of early pregnancy breast cancer protection
10. Embryonic stem cells might help reduce transplantation rejection
11. Scientists isolate cancer stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
When cells go bad
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader in ... biometric technology to industry leaders such as Intel, Jabra, ... validated, biometric wearable products. These products will be showcased ... Las Vegas . "Our ...
(Date:12/11/2014)... 09, 2014 Research and Markets , ... ) has announced the addition of the "Biometrics ... One major trend emerging in this ... biometric systems utilize more than one characteristic of an ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center today ... School of Medicine. Funding for this $50 million capital project ... publicly launched next summer. The medical education ... Reynolds Tobacco Company complex, adjacent to 525@vine in Wake Forest ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... next-generation DNA sequencing technologies have been turned on typhoid ... year. The results will help to improve diagnosis, tracking ... strategies for vaccination. The study sets a new ... disease-causing bacterium: it is the first study of multiple ...
... NYU Langone Medical Center researchers have long been making ... were among the first to characterize amyloid, the plaque-forming ... a genetic mutation in a familial form of the ... to reduce the need for placing patients in nursing ...
... a new 5,000-square-foot exhibition, "Dig it! The Secrets of ... The exhibition will travel to museums across the country ... along with the President of the Soil Science Society ... new "Dig It! The Secrets of Soil" exhibition, ...
Cached Biology News:Defining DNA differences to track and tackle typhoid 2Defining DNA differences to track and tackle typhoid 3NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 2NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 3NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 4NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 5NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 6NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 7NYU Langone Medical Center's tip sheet to the International Conference on Alzheimer's Disease 2008 8
(Date:1/22/2015)... 22, 2015 Shimadzu Scientific Instruments ... multipurpose UV-visible spectrophotometer. Offering wavelength scanning from 190 ... ideal for applications in a variety of industries, ... The user-friendly UV-1280 enables intuitive operation, while the ...
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... Johnston, RI (PRWEB) January 22, 2015 ... State , The growing team of brand-neutral, independent consultants, ... CIO Philip Rogers explained that over the years, his ... including , Moroso, Town of Plainfield, as well as ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2
... presentations from industry and academic speakers who possess unique expertise ... Topics include Chemical and Process R&D, Crystallization, Process Safety, ... , ... Columbia, MD (PRWEB) February ...
... The ability to empathize with others is partially ... from the University of Wisconsin-Madison and Oregon Health and ... social strain of mice learned to associate a sound ... by hearing a mouse in that cage respond with ...
... Market and Technology Expansion in Presentation to InvestorsINDIANAPOLIS, Feb. ... delivering beyond expectations was the focus of a recent ... CEO of Dow AgroSciences. Dow AgroSciences is a ... DOW ). Peribere spoke to investors ...
Cached Biology Technology:16th International Process Development Conference to be Held June 14-17, 2009 in Arosa, Switzerland 2Mouse study reveals genetic component of empathy 2Mouse study reveals genetic component of empathy 3Dow AgroSciences Delivering Beyond Expectations 2Dow AgroSciences Delivering Beyond Expectations 3
Ultra-sensitive, non-radioactive detection of rat Big Endothelin-1 (Big ET-1)...
Request Info...
Request Info...
Peptide Sequence: ovine COX-1 amino acids 272-282 (LMHYPRGIPPQ) To be used in conjunction with Cayman's COX-1 (ovine) polyclonal antiserum (Catalog No. 160108) to block protein-antibody complex f...
Biology Products: