Navigation Links
When cells go bad
Date:9/30/2008

SALT LAKE CITY -- When a cell's chromosomes lose their ends, the cell usually kills itself to stem the genetic damage. But University of Utah biologists discovered how those cells can evade suicide and start down the path to cancer.

Details of how the process works someday may provide new ways to treat cancer.

The new study of fruit flies is the first to show in animals that losing just one telomere the end of a chromosome can lead to many abnormalities in a cell's chromosomes, which are strands of DNA that carry genes.

"The essential point is that loss of a single telomere may be a primary event that puts a cell on the road to cancer," says Kent Golic, a professor of biology at the University of Utah and senior author of the study, which will be published online this week in the December issue of the journal Genetics.

Fruit flies have four pairs of chromosomes. Humans have 23 pairs. Each chromosome has two ends, called telomeres, which often are compared with the plastic tips of shoe laces. When those tips are lost or break, the shoelace frays. Previous research has shown that aging and cancer often are associated with loss or shortening of telomeres.

Damaged Cells Usually Kill Themselves to Avoid Becoming Cancerous

To protect an organism against cancer, most cells with broken or missing telomeres undergo "apoptosis," also known as cell suicide. But Golic and Simon Titen, a postdoctoral fellow in biology, found how fruit fly cells with a missing telomere sometimes avoid suicide and instead continue to divide and develop early characteristics of cancer.

Normally when a chromosome is damaged, the cell carrying the chromosome turns on a gene named p53, which helps kill the cell. When mutated, p53 fails to carry out this vital function. That is why mutant p53 is a cancer-causing gene and is found in most human tumors.

Golic and Titen found that normal p53 and so-
'/>"/>

Contact: Lee Siegel
leesiegel@ucomm.utah.edu
801-581-8993
University of Utah
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. NSF funds new Center for the Physics of Living Cells at Illinois
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. Pittsburgh researchers identify source of multipotent stem cells with broad regenerative potential
4. St. Jude study gives new insights into how cells accessorize their proteins
5. UNC scientists turn human skin cells into insulin-producing cells
6. Colorful spy tactics track live cells supporting cancerous tumors
7. Flatworm helps researchers study stem cells and cancer
8. Viral magic bullet targets cancer cells with help of new compound
9. Stem cells may solve mystery of early pregnancy breast cancer protection
10. Embryonic stem cells might help reduce transplantation rejection
11. Scientists isolate cancer stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
When cells go bad
(Date:11/5/2014)... professor of biology in the UTSA College of ... nation selected to receive a two-year $300,00 National ... Research (EAGER). The funding supports President Obama,s BRAIN ... create new technology that will demystify complex brain ... in neuroscience are broken into the interactions of ...
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... the right amount of death at the right time ... to new research that could help in understanding animal ... , In a paper in the journal Trends ... and European colleagues conclude that the kind of positive ... of individuals, or mortality, depends on the size and ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3The female nose always knows: Do women have more olfactory neurons? 2When less is more: Death in moderation boosts population density in nature 2
... Cancer Research Center have, for the first time, induced ... achievement, the first demonstration of "hibernation on demand" in ... treat cancer and prevent injury and death from insufficient ... in essence, temporarily converting mice from warm-blooded to cold-blooded ...
... that are invisible by ordinary means of detection, according ... of Medicine in St. Louis. , The researchers demonstrated ... from the surrounding tissue by direct MRI scan--could be ... minutes after the mice were injected with the nanoparticles. ...
... the March issue of the journal Cancer Cell describes a ... to a new avenue for targeted cancer therapy. The compound, ... mouse model system and has low toxicity. The results of ... in phase I clinical trials. , Plk1 is a molecule ...
Cached Biology News:Buying Time Through Hibernation on Demand 2Buying Time Through Hibernation on Demand 3Buying Time Through Hibernation on Demand 4Buying Time Through Hibernation on Demand 5Nanoparticles offer new hope for detection and treatment 2Nanoparticles offer new hope for detection and treatment 3New drug shows promise as powerful anticancer agent 2
(Date:11/21/2014)... 21, 2014   TRU-D SmartUVC LLC and its ... UVC automated disinfection robot, TRU-D SmartUVC, at FIS 2014 in ... 23 to 26 at Stand 23. The conference, ... United Kingdom,s largest infection-related event of its kind ... one of the leading events of its type throughout the ...
(Date:11/21/2014)... 2014 Offering a complete line of ... Balance promotion . The Sartorius Entris Balance is the ... accuracy, and easy-to-maintain balance entry level balance. , The ... designed to help customer’s bridge the gap between a ... is very durable. Sartorius is the second biggest balance ...
(Date:11/21/2014)... Alto, Calif. (PRWEB) November 20, 2014 ... a nonprofit, public policy research organization representing leading ... pharmaceutical firms, and PwC US today ... states in life sciences industry growth. The trend ... 2013. The 2015 California Biomedical Industry Report ...
(Date:11/21/2014)... 2014 The November 2014 issue of ... open access journal featuring the following articles:, ... preserve photoresponsiveness in the retina , DNA ... hybridization using chromogenic substrates in zebrafish , ... protein electrophoresis , Nuclear LC3-positive puncta in ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... YORK, Aug. 3, 2011 Reportlinker.com ... report is available in its catalogue: ... Commercial Outlook 2011-2021 - discovering the ... http://www.reportlinker.com/p0578545/Biomarkers-Technological-and-Commercial-Outlook-2011-2021---discovering-the-pharma-and-diagnostics-opportunities.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genomics ...
... PRINCETON, N.J., Aug. 2, 2011 Informex ... sellers of high-value chemistry, today announced the introduction ... Positioning and Partnering for the Biopharmaceutical Evolution, to ...  The two day conference will cover on-trend topics ...
... 2, 2011 , New app edition ... anytime , ,Elsevier, the leading provider of scientific, technical ... Gray,s Anatomy for Students App, for iPad, is now available ... Gray,s Anatomy for Students, Second Edition . , ,The Gray,s ...
Cached Biology Technology:Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 2Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 3Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 4Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 5Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 6Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 7Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 8Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 9Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 10Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 11Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 12Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 13Biomarkers: Technological and Commercial Outlook 2011-2021 - Discovering the Pharma and Diagnostics Opportunities 14New Conference Offers Solutions for Success in the Growing Biologics Market 2New Conference Offers Solutions for Success in the Growing Biologics Market 3Gray's Anatomy for Students, World's Bestselling Anatomy Textbooks, Now Available on iPad 2Gray's Anatomy for Students, World's Bestselling Anatomy Textbooks, Now Available on iPad 3
...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
Fluorescence Preserving Media, 100 mL...
... Blunt-Ended PCR Cloning Kit, 40 reactions. ... cloning of all PCR products with ... cloning approaches by offering consistently better ... 25-fold more positive clones.Amplicons generated by ...
Biology Products: