Navigation Links
When cells 'eat' their own power plants; Pitt scientists solve mystery of cellular process
Date:9/30/2013

p>

However, that is only part of the process, says Charleen T. Chu, M.D., Ph.D., professor and the A. Julio Martinez Chair in Neuropathology in the Pitt School of Medicine's Department of Pathology, another senior author of the study. "It's not just the turkey timer going off; it's a question of who's holding the hot mitt to bring it to the dining room?" That turns out to be a protein called LC3. One part of LC3 binds to cardiolipin, and LC3 causes a specialized structure to form around the mitochondrion to carry it to the digestive centers of the cell.

The research arose nearly a decade ago when Dr. Kagan had a conversation with Dr. Chu at a research conference. Dr. Chu, who studies autophagy, or "self-eating," in Parkinson's disease, was seeking a change on the mitochondrial surface that could signal to LC3 to bring in the damaged organelle for recycling. It turned out they were working on different sides of the same puzzle.

Together with Hlya Bayır, M.D., research director of pediatric critical care medicine, Children's Hospital of Pittsburgh of UPMC and professor, Pitt's Department of Critical Care Medicine, and a team of nearly two dozen scientists, the three senior authors worked out how the pieces of the mitochondria signaling problem fit together.

Now that they've worked out the basic mechanism, many more research directions will likely follow, said Dr. Chu.

"There are so many follow-up questions," she said. "What is the process that triggers the cardiolipin to move outside the mitochondria? How does this pathway fit in with other pathways that affect onset of diseases like Parkinson's? Interestingly, two familial Parkinson's disease genes also are linked to mitochondrial removal."

Dr. Bayir explained that while this process may happen in all cells with mitochondria, it is particularly important that it functions correctly in neuronal cells because these cells do not divide and regenerate as readily as
'/>"/>

Contact: Allison Hydzik
hydzikam@upmc.edu
412-647-9975
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New research shows how heart cells communicate to regulate heart activity
2. Specific sugar molecule causes growth of cancer cells
3. UAlberta medical researchers discover how immune system kills healthy cells
4. Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
5. Youthful stem cells from bone can heal the heart, Temple scientists report
6. Research identifies how mouth cells resist Candida infection
7. Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
8. UC Davis team spikes stem cells to generate myelin
9. Why are some cells more cancer prone?
10. Harvard Stem Cell researchers create cells that line blood vessels
11. UCI-led study reveals how SARS virus hijacks host cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... of increasing concern about the prevalence of antibiotic-resistant ... promising new pathway to disabling disease: blocking bacteria,s ... scientists showed how bacterial siderophore, a small molecule, ... fan bacterial growth as well as how ... infection process. Their findings appear in a recent ...
(Date:7/9/2014)... upon us, many backyard cooks are turning to more ... But low fat can sometimes mean low satisfaction. Now ... problem in low-fat wieners that are made with olive ... in ACS, Journal of Agricultural and Food Chemistry ... hot-dog consumers have come to expect just the right ...
(Date:7/9/2014)... challenges the commonly held belief that birds evolved from ... The birdlike fossil is actually not a dinosaur, as ... tiny tree-climbing animal that could glide, say American researchers ... and Alan Feduccia of the University of North Carolina. ... . , The fossil of the Scansoriopteryx ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... Smithsonian,s Barro Colorado Island research station in Panama, organized ... Science, Policy & Management at the University of California, ... since the first census 33 years ago. Long ... and a group of stalwart volunteers, each armed with ...
... for Marine Sciences at the University of Gothenburg have discovered ... Gullmarsfjord north of Gothenburg. The bacterium has been named ... center. Researcher Matthias Obst from the Department of ... Sven Lovn Centre for Marine Sciences, a new institute owned ...
... and calcium supplements appear to reduce the risk of breast ... Cancer Research 101st Annual Meeting 2010. "It is ... and your breast cancer risk is reduced tomorrow," said Jaime ... Puerto Rico. "However, we did see a long-term effect in ...
Cached Biology News:A howling success: The fifth howler monkey census on Barro Colorado Island 2
(Date:1/15/2014)... Cynvenio, a cancer diagnostics company focused ... analysis of tumor cells in the bloodstream, today announced ... decision support application powered by CollabRx, Inc. , ... test, Therapy Finder will provide breast cancer patients and ...
(Date:1/15/2014)... January 15, 2014 This webinar will ... and clinical safety assessment in biosimilars. , Regulatory frameworks ... biosimilar drug development, however the complex nature of biopharmaceuticals ... safety and efficacy extremely challenging. Based on the specific ...
(Date:1/15/2014)... Two champions of science, technology, engineering, and mathematics ... competition for middle and high school students designed to ... The competition presents students with real-world problems experienced by ... and Sciences is a program administered by the ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Roche Diabetes Care, makers of ACCU-CHEK® products and services, ... diabetes education, awareness and advocacy. The company has also ... North America. Roche Diabetes Care,s Facebook ... www.twitter.com/accuchek_us ) accounts have been created with one goal ...
... In some areas of Virginia, blackbirds are causing moderate to ... the state has issued a Section 18 exemption to the ... farmers to use Avipel® Crop Seed Treatment to protect their ... of bird damage to crops is not unique to this ...
... 2011 DDC (DNA Diagnostics Center), the largest provider of ... and worldwide, invites international attendees for a tour and behind ... 2011 at 3 p.m. at DDC, One DDC Way, Fairfield, ... Network Conference: An International Exploration of Wrongful Conviction held in ...
Cached Biology Technology:Roche Diabetes Care in the U.S. Turns to Social Media to Promote Diabetes Education, Awareness and Advocacy 2Roche Diabetes Care in the U.S. Turns to Social Media to Promote Diabetes Education, Awareness and Advocacy 3Bird Repellent Gains Approval by Virginia 2DDC to Name DNA Analyzer "Hello Truth" During Innocence Project International Delegate Tour 2
Human peripheral blood PBMCs, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Human peripheral blood CD56+ NK cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Monocytes, B Cells, NK Cells and Stem Cells...
Biology Products: