Navigation Links
When a KISS (1) goes bad
Date:4/16/2013

KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published online in the journal Endocrinology.

Moshmi Bhattacharya, an associate professor in the Departments of Physiology and Pharmacology, and Oncology, was surprised to find high levels of kisspeptins in aggressive breast cancers. "We found kisspeptins could turn non-invasive cancer cells into invasive cells, and therefore could be playing a role in the metastasis of breast cancer."

The paper's first author Donna Cvetkovic, a graduate student working with Bhattacharya, says they were also able to pinpoint what triggered kisspeptin to act in this unusual fashion. "Typically breast cancers are classified as being estrogen receptor-positive or estrogen receptor-negative. In estrogen receptor-negative cells we found that kisspeptin significantly increased invasiveness. However in cells that still expressed estrogen, kisspeptin does not lead to invasion," says Cvetkovic. "We believe that estrogen is acting as a brake, and when patients lose their estrogen receptor, it allows kisspeptin to behave in a non-typical fashion."

"As for clinical applications, testing to see whether the kisspeptin receptor is present or not, could provide us with an idea of whether the breast cancer will become more aggressive and thereby more metastatic," says Bhattacharya, a New Investigator with the Canadian Institutes of Health Research (CIHR) which funded this study. She also believes kisspeptins could be a good therapeutic target.


'/>"/>

Contact: Kathy Wallis
kwallis3@uwo.ca
519-661-2111 x81136
University of Western Ontario
Source:Eurekalert

Page: 1

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2017)... , Feb. 3, 2017 A new independent ... Strategy Partners, LLP (IdSP) . Designed to fill a ... complex identity market, founding partners Mark Crego ... combined years just in identity expertise that span federal ... non-profit leadership. The Crego-Kephart combined expertise has a common ...
(Date:2/2/2017)...  Central to its deep commitment to honor ... Japan Prize Foundation today announced the laureates of ... envelope in their respective fields of Life Sciences ... being recognized with the 2017 Japan Prize for ... to the advancement of science and technology, but ...
(Date:1/30/2017)... --  Invitae Corporation (NYSE: NVTA ), ... announced that it will report its fourth quarter and ... Monday, February 13, 2017, and Invitae,s management team will ... Eastern / 1:45 p.m. Pacific. During ... results, guidance, and recent developments and will spend the ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... Mass. , Feb. 17, 2017  If ... small tumor had a mutation-conferring resistance to chemotherapy, ... Recently, genomics research has focused on finding these ... or even from circulating tumor DNA in blood ... new oncology therapeutics. Unfortunately, however, detecting ...
(Date:2/16/2017)... , Feb. 16, 2017  ImMAGE Biotherapeutics (OTCMKTS: IMMG), ... system to find a better treatment for triple negative breast ... in France program. The ... an accelerator designed to help entrepreneurs grow their business in ... one of eight American companies selected to complete an intensive ...
(Date:2/16/2017)... , Feb. 16, 2017   Capricor ... a clinical-stage biotechnology company developing first-in-class biological therapies ... that it has elected to terminate its license ... peptide receptor agonists, including Cenderitide. "Our ... move as we prioritize our efforts to advance ...
(Date:2/16/2017)...  Champions Oncology, Inc. (NASDAQ: CSBR ), ... advanced technology solutions and products to personalize the development ... of new cohorts of PDX models to their existing ... Champions, product line in hepatocellular cancer, breast cancer, castrate ... non-small cell lung cancer (including EGFR mutation; ALK/ROS1 positive) ...
Breaking Biology Technology: