Navigation Links
When It Comes To Genetic Code, Researchers Prove Optimum Isn't Always Best
Date:2/18/2013

the University of Texas Southwestern Medical Center, was perplexed when it found a paradoxical result years ago: that optimizing the use of codons (a sequence of three nucleotides that form a unit of genetic code in a DNA or RNA molecule) specifying an essential biological clock component actually abolished the organism's circadian rhythms.

The group's research indicates that the protein in the fungal genus Neurospora they studied, frequency, performs better when the genetic code specifying it has non-optimal codon usage, as is normally found. However, when the genetic code is deliberately altered so that codon usage is optimized, clock function is lost. The reason for this is that non-optimal codon usage slows translation of the genetic code into protein, allotting the frequency protein the necessary time to achieve its optimal protein structure. The team's results also demonstrate that genetic codons do more than simply determine the amino acid sequence of a protein as previously thought: They also affect how much protein can be made as well as the functional quality of that protein.

"We found that less is more, in many cases," Liu said.

Because many genetic diseases are the result of improperly functioning proteins, Sachs says knowledge about how proteins are made and why they have impaired functions is critical to understanding almost all diseases.

"Understanding gene expression is crucial for understanding cancer and other diseases, because ultimately many of these processes involve either mutations of genes or altered expression of genes," said Sachs, who was asked by Liu to help on the research because of his translational expertise in Neurospora.

In addition to Liu and Sachs, the paper's authors include Mian Zhou , Jinhu Guo , Joonseok Cha and Michael Chae , all from the D
'/>"/>

SOURCE Texas A&M University
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. AGU: Gasoline worse than diesel when it comes to some types of air pollution
2. When your ship comes in
3. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
4. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
5. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
6. Early detection techniques offer hope for improved outcomes in lung cancer patients
7. Freeing loggerhead turtles comes at a price
8. UGA study finds theres not always safety in numbers when it comes to extinction risk
9. EMBO welcomes 55 leading life scientists as members
10. How one strain of MRSA becomes resistant to last-line antibiotic
11. Study finds voter genetics may predict election outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... Plants rely on sunlight to make their food, but they ... do. Recently, scientists discovered a group of molecules in plants ... in the Journal of the American Chemical Society , ... plant sunscreens work. , Timothy Zwier and colleagues at Purdue ... to daily can cause serious damage to plant DNA and, ...
(Date:10/29/2014)... all the rage. Thousands of scientists worldwide are conducting ... titanium dioxide nanoparticles from sun creams can get through ... from electronic products are as hazardous for the lungs ... food can get into the blood via the intestinal ... are flowing – and the number of scientific projects ...
(Date:10/29/2014)... bodies decompose, their types and numbers of bugs ... could mean the difference between a closed case ... is using a more than $866,000 U.S. Department ... examine these changing populations. The microbial communities may ... death, gender, race, socioeconomic relations and more, said ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3MSU partners with Detroit to investigate death scenes 2
... is closely tied to its sexual habits, ecologists have ... such intimate relationships between plants and pollinators, the study ... published online in the British Ecological Society,s journal Functional ... in certain bumblebee species found in the shrinking areas ...
... . Over the past decades climate change ... given rise to a growing scientific interest in the ... dominate our energy map are not only becoming scarce, ... Within the field of renewable energies the scientific community ...
... IMMEDIATE RELEASE Fighting global warming at ... Substituting chicken, fish, or vegetables for red meat ... even more dramatically than buying locally sourced food, ... impacts of food production and distribution in the United ...
Cached Biology News:Ecologists tease out private lives of plants and their pollinators 2More efficient fuel-cells, thanks to a new catalyst 2More efficient fuel-cells, thanks to a new catalyst 3More efficient fuel-cells, thanks to a new catalyst 4American Chemical Society's Weekly PressPac -- April 30, 2008 2American Chemical Society's Weekly PressPac -- April 30, 2008 3American Chemical Society's Weekly PressPac -- April 30, 2008 4American Chemical Society's Weekly PressPac -- April 30, 2008 5American Chemical Society's Weekly PressPac -- April 30, 2008 6American Chemical Society's Weekly PressPac -- April 30, 2008 7American Chemical Society's Weekly PressPac -- April 30, 2008 8
(Date:10/31/2014)... This is a professional and in-depth ... The report provides basic biocides information, including its ... well as industry overview. This research covers the ... well as Global industry analysis covering macroeconomic environment ... Chinese biocides industry covers information on ...
(Date:10/31/2014)... ENVIRON , an international ... that Dr. Harvey Clewell III has rejoined the ... closely with senior professionals in ENVIRON’s Health Sciences ... at The Hamner Institutes for Health Sciences (The ... he is Director, Center for Human Health Assessment. ...
(Date:10/31/2014)... , Oct. 31, 2014  Atlanta-based Intellimedix could ... accompanying the onset of Ebola by suggesting a ... at Georgia Tech,s Center for Computational Systems Biology ... to find alternative uses for existing drugs through ... to aid the bout against Ebola. ...
(Date:10/30/2014)... 30, 2014  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that ... on Thursday, November 6, 2014. Following the announcement, ... conference call and webcast at 4:30pm ET to ... business update. The live webcast can ...
Breaking Biology Technology:Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2
... - Taking more women-owned businesses to the $1 million annual ... perhaps none more important than information technology. , ,That was ... Wisconsin Make Mine a Million program, where women-owned ... extent in their quest to reach the $1 million mark. ...
... Editor's note: Attorney Greg Lynch, a partner with ... on this article with Laura Riske, the firm's director of ... - The United States Department of Energy has ... , ,This funding opportunity is open to applicants with projects ...
... - MailFoundry , a Green Bay anti-spam solution provider, ... 100,000 users and 20 million e-mails per day. , ,The ... this week's Interop exhibit in Las Vegas. , ,The series ... attacks, viruses, and botnets. It comes with MessageIQ 3.0, the ...
Cached Biology Technology:Learning from the big boys: With technology, women urged to go gradual 2Learning from the big boys: With technology, women urged to go gradual 3Wisconsin applicants urged to pursue DOE funding for cellulosic biomass 2
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
... first identified as the cellular homolog of the ... Jun D have been shown to be almost ... are involved in dimerization and DNA binding, whereas ... activation, diverge. Antigen: The ...
...
... (phospho Y1007) ( Abpromise for ... Antigen: Synthesized phosphopeptide derived from ... of tyrosine 1007 (K-E-Y P -Y-K). ... 3717 Swiss ...
Biology Products: