Navigation Links
What's in a name? Broadening the biological lexicon to bolster translational research
Date:3/9/2011

arch with zebrafish. She uses zebrafish as a something of a test tube in which to study human mental health disorders, including schizophrenia, bipolar disorder, and autism. Knowing full well that zebrafish don't get autism, Sive nonetheless has employed the fish successfully as tools because she also knows that mental health risk genes in humans have homologs in zebrafish and that these genes are active during brain development. Because of this, Sive and her lab are able to conduct loss-of-function studies on these genes, examine what happens to the developing brain, and screen for chemicals that can alter the genes' activity. Such work could help identify potential therapeutic targets.

Having heard Sive discuss this 'tool-model' construct several years ago, Vivian Siegel, editor of Disease Models & Mechanisms, encouraged Sive to share it with the scientific community at large.

"She did exactly what I was hoping she would do." Siegel says of Sive's editorial. "We wanted to emphasize that you can find utility without the disease being recapitulated, as long as you know the limitations of the system."

Both Sive and Siegel, whose journal focuses on publishing basic research with translational impact, believe increased but judicious adoption of the term 'tool' should encourage researchers to consider new uses for their systems of choice, help educate grant reviewers evaluating related applications, and ultimately lead to greater understanding of human disorders.

"If you adhere strictly to the term 'model', you can be misled by your own system," says Siegel. "This approach has a lot of benefits. My hope is that by publishing this in Disease Models & Mechanisms, it reaches out to people interested in translational research, and lets others know that they needn't be so dismissive of certain aspects of looking at organisms. This offers a new way to help recognize the potential contributions of organisms that aren't necess
'/>"/>

Contact: Nicole Giese
giese@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Symposium to explore broadening partnerships to spur medical advances for war injuries
2. Biological sand filters, a practical approach to combat poverty and inequality
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. GEN reports on novel tools for deciphering biological networks
5. Animal and biological science highlights: San Antonio Fluid Dynamics Conference, Nov. 23-25
6. Argonne scientists discover possible mechanism for creating handedness in biological molecules
7. Study finds most wars occur in Earths richest biological regions
8. Biological control of tropical weeds using arthropods
9. Musicians have biological advantage in identifying emotion in sound
10. Unclear regulations obstacle to biological diversity
11. New explanation for a puzzling biological divide along the Malay Peninsula
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... women suggests that experiencing one or more stressful events ... slow the body,s metabolism, potentially contributing to weight gain. ... stressors before giving them a meal consisting of 930 ... measured their metabolic rate how long it took ... took measures of blood sugar, triglycerides, insulin and the ...
(Date:7/13/2014)... available in French . ... international research project, led by the Research Institute of ... that a new oral medication is showing significant progress ... (LCA). Until now, this inherited retinal disease that causes ... has remained untreatable. The study is published today in ...
(Date:7/13/2014)... prospect of more effective treatments for cachexia, a profound ... of all cancer patients, raising their risk of death, ... strategies have been tried to reverse the condition, which ... life-saving treatments, but none have had great success. , ... of Nature , led by Bruce Spiegelman, PhD, ...
Breaking Biology News(10 mins):Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4MUHC researcher unveils novel treatment for a form of childhood blindness 2Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3
... derivative, and was approved for the treatment of neuropathic ... 2002. However, little evidence is available on the effects ... attack period. A recent study by Yanbo Zhang and ... showed that excitatory amino acids and protein kinase C ...
... Ectobius is a major textbook example of an invasive ... region from northernmost Europe to southernmost Africa. Ectobius ... amber that is about 44 million years old, and its lineage ... a shocking new discovery has uprooted that view. In fact, it ...
... stink bugs as pests, especially as the brown marmorated stink ... beneficial, such as Podisus nigrispinus (Dallas), a predatory ... for various insect pests of cotton, soybean, tomato, corn, kale, ... Annals of the Entomological Society of America called ...
Cached Biology News:After a 49-million-year hiatus, a cockroach reappears in North America 2New study may aid rearing of stink bugs for biological control 2
(Date:7/11/2014)... BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ -- ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... Research and Markets  has announced the ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is ... or RNA) into cells. This technology helps the cells ... protein metabolism by affecting the nuclear genes. The transfection ...
(Date:7/11/2014)... , July 11, 2014 EPFL ... announce the appointment of John P. Donoghue . ...   in  Geneva . The new ... Biotech in Geneva , has named ... neuroscientists. John P. Donoghue , founder of Brown ...
(Date:7/11/2014)... July 11, 2014  Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... YORK, Oct. 6, 2011 A new invention could ... is a portable, rapid pathogen screener that could ... in processing plants, before it is delivered to the ... as a single bacteria, and is approximately 50 times ...
... 6, 2011 ProteinSimple today announced the launch ... control monitoring of protein-based therapeutics. The iCE3 platform ... conference, October 9-13, 2011, at Amelia Island, FL. ... product purity closely. Imaged capillary electrophoresis (iCE) systems ...
... Luminex Corporation (NASDAQ: LMNX ) announced today that ... – Be The Match to raise awareness of the need ... match for the growing number of patients awaiting life-saving bone ... National Marrow Donor Registry in an effort to assist patients ...
Cached Biology Technology:Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 2Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 3Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 4ProteinSimple Launches New System for Protein Biologics 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 3Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 4
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
Mouse monoclonal [2D7/1] to E.coli LPS ( Abpromise for all tested applications). Antigen: Tissue / cell preparation: Escherichia coli J5 cells....
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
KAI 1 (G-2)...
Biology Products: