Navigation Links
What you eat and not just the number of calories, is a significant factor in diabetes risk

If you think losing weight is enough to prevent Type 2 diabetes, don't get your hopes up. A new research report in September 2014 issue of The FASEB Journal, suggests that you don't have to be overweight to develop Type 2 diabetes. This study compared genetically identical twins-one heavier and one leaner-and found that after eating a fast-food meal, the circulating metabolites, including those related to Type 2 diabetes, were found in both individuals at the same levels. These findings suggest that the onset of this type of diabetes is largely influenced by genetic factors and/or the composition of gut microbiota.

"Our study contributes to better understanding of the genetic and environmental factors influencing several risk factors which are associated with obesity and metabolic disease (e.g., Type 2 diabetes)," said Matej Oresic, Ph.D., study author from the Steno Diabetes Center in Gentofte, Denmark. "As such, our study may contribute to the efforts aimed at prevention and treatment of metabolic complications associated with obesity."

To make this discovery, scientists studied identical twin pairs, where the twins differed in weight. They were healthy young adults from a national (Finnish) study of twins. The twins ate a fast food meal, and then gave many blood samples over several hours. A broad panel of small molecules (i.e., metabolites) was measured in blood, including amino acids, fatty acids and bile acids. The diversity of fecal microbiota also was assessed at the baseline. Results showed that twin-pair similarity is a dominant factor in the metabolic postprandial response, independent of obesity. Branched chain amino acids, known risk factors of diabetes, were increased in heavier as compared to leaner co-twins in the fasting state, but their levels converged postprandially. This study also demonstrated that specific bacterial groups were associated with postprandial changes of specific metabolites. This is the first comprehensive study examining metabolic postprandial responses in twins discordant for weight.

"When someone is overweight and at risk for diabetes, the conventional wisdom is to say 'lose weight,'" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and to a degree that recommendation holds true. This report, however, shows that a calorie is not just a calorie as some would contend. Exactly what we eat and drink, and not just the number of calories, may be the most important factor in our health."

Contact: Cody Mooneyha
Federation of American Societies for Experimental Biology

Related biology news :

1. Kalorama Report: Sizable Number of Acquisitions and Joint Ventures in Molecular Diagnostics
2. Gastroenterology remains number one GI and hepatology journal
3. Invertebrate numbers nearly halve as human population doubles
4. Measuring the number of protein molecules inside cells
5. Epigenetic regulation required to ensure correct number of chromosomes
6. Study shows large carnivore numbers and range declining worldwide
7. EU policy is driving up demand for pollination faster than honeybee numbers
8. New energy harvesting technology set to reduce number of open-heart surgeries
9. Safety in numbers? Not so for corals
10. In odd-looking mutant, clues about how maize plants control stem cell number
11. Tiny number of Asian carp could be big problem for the Great Lakes
Post Your Comments:
(Date:11/18/2015)... 18, 2015  As new scientific discoveries deepen our ... other healthcare providers face challenges in better using that ... In addition, as more children continue to survive pediatric ... and old age. John M. Maris, M.D ... of Philadelphia (CHOP) . --> John ...
(Date:11/17/2015)... SOUTH EASTON, Mass. , Nov. 17, 2015 /PRNewswire/ ... "Company"), a leader in the development and sale of ... to the worldwide life sciences industry, today announced it ... closing of its $5 million Private Placement (the "Offering"), ... Offering to $4,025,000.  One or more additional closings are ...
(Date:11/11/2015)... 2015   MedNet Solutions , an innovative SaaS-based eClinical ... is pleased to announce that it will be a Sponsor ... event, to be held November 17-19 in Hamburg ... demonstrations of iMedNet , MedNet,s easy-to-use, proven ... has been able to deliver time and cost savings ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015  PharmAthene, Inc. (NYSE MKT: PIP) announced  today ... rights plan (Rights Plan) in an effort to preserve ... under Section 382 of the Internal Revenue Code (Code). ... use of its NOLs could be substantially limited if ... Section 382 of the Code. In general, an ownership ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... , President and CEO of Neurocrine Biosciences, will be ... in New York . ... the website approximately 5 minutes prior to the presentation ... of the presentation will be available on the website ...
(Date:11/25/2015)... 25, 2015 The Global ... a professional and in-depth study on the current ... (Logo: ) , The ... including definitions, classifications, applications and industry chain structure. ... international markets including development trends, competitive landscape analysis, ...
(Date:11/24/2015)... , Nov. 24, 2015 Cepheid (NASDAQ: ... be speaking at the following conference, and invited investors ... York, NY      Tuesday, December 1, 2015 at ... York, NY      Tuesday, December 1, 2015 at ... Healthcare Conference, New York, NY ...
Breaking Biology Technology: