Navigation Links
What is a laboratory mouse? Jackson, UNC researchers reveal the details
Date:5/29/2011

s complete genomic data on 162 mouse strains. "The viewer provides scientists with a visual tool where they can actually go and look at the genome of the mouse strains they are using or considering, compare the differences and similarities between strains and select the ones most likely to provide the basis for experimental results that can be more effectively extrapolated to the diverse human population," said Pardo-Manuel de Villena.

"As scientists use this resource to find ways to prevent and treat the genetic changes that cause cancer, heart disease, and a host of other ailments, the diversity of our lab experiments should be much easier to translate to humans," he noted.

Churchill and Pardo-Manuel de Villena have been working for almost a decade with collaborators around the world to expand the genetic diversity of the laboratory mouse. In 2004 they launched the Collaborative Cross, a project to interbreed eight different strains--five of the classic inbred strains and three wild-derived strains. In 2009 Churchill's lab started the Diversity Outbred mouse population with breeding stock selected from the Collaborative Cross project.

The research team estimates that the standard laboratory mouse strains carry about 12 million single nucleotide polymorphisms (SNPs), single-letter variations in the A, C, G or T bases of DNA. The Collaborative Cross mice deliver a whopping 45 million SNPs, as much as four times the genetic variation in the human population. "All these variants give us a lot more handles into understanding the genome," Churchill says.

"This work creates a remarkable foundation for understanding the genetics of the laboratory mouse, a critical model for studying human health," said James Anderson, Ph.D., who oversees bioinformatics grants at the National Institutes of Health. "Knowledge of the ancestry of the many strains of this invaluable model vertebrate will not only inform future experimentation but will allow
'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory March 2011
2. Story tips from the Department of Energys Oak Ridge National Laboratory January 2011
3. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
4. Developmental biology is focus of new volume in laboratory manual series on imaging
5. Pacific Northwest National Laboratorys 2010 AGU tip sheet
6. Story tips from the Department of Energys Oak Ridge National Laboratory -- December 2010
7. First volume of new laboratory manual series on imaging is released
8. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
9. Story tips from the US Department of Energys Oak Ridge National Laboratory October 2010
10. Cold Spring Harbor Laboratory neuroscientist awarded Transformative NIH research grant
11. UMCES Chesapeake Biological Laboratory to rebuild historic research pier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... the world,s largest scientific society, invites news media ... September 8-12, 2013, in Indianapolis, Ind. It will ... at area hotels. , With more than 7,100 ... from astronomy to zoology ― the meeting ... rich assortment of spot news and feature possibilities. ...
(Date:5/21/2013)... which alter the way genes function without changing ... in the blood of pregnant women during any ... depression in the weeks after giving birth, and ... , The findings of the small study involving ... journal Molecular Psychiatry . , "Postpartum depression ...
(Date:5/20/2013)... suggests that a compound abundant in the Mediterranean diet ... , By altering a very specific step in gene ... cells that die as scheduled. , One way that ... would cause them to die on a regular cycle ... cells, led by Ohio State University researchers, found that ...
Breaking Biology News(10 mins):Genetic predictors of postpartum depression uncovered by Hopkins researchers 2Genetic predictors of postpartum depression uncovered by Hopkins researchers 3The compound in the Mediterranean diet that makes cancer cells 'mortal' 2The compound in the Mediterranean diet that makes cancer cells 'mortal' 3
... may be at risk to higher sea levels accompanied by ... to a new study by NOAA. The study was ... the East Coast during the 2009-2010 El Nio winter. ... for Operational Oceanographic Products and Services, examined water levels and ...
... on the way antibodies distinguish between different but ... about the condition of the human body. This ... new technologies for quickly diagnosing and treating fatal ... of proteins, specifically linked to them called biomarkers. ...
... a pivotal breakthrough in the development of a cable that ... Armchair quantum wire (AQW) will be a weave of ... long distances. It will be an ideal replacement for the ... percent per 100 miles of transmission, said Rice chemist Andrew ...
Cached Biology News:Strong El Niño could bring increased sea levels, storm surges to US East Coast 2New understanding of biomarkers could lead to earlier diagnosis of fatal diseases 2New understanding of biomarkers could lead to earlier diagnosis of fatal diseases 3'Amplified' nanotubes may power the future 2'Amplified' nanotubes may power the future 3
(Date:5/21/2013)... Boston, MA (PRWEB) May 21, 2013 Possible ... parents. And so, according to a report from eagletribune.com posted ... for mold. In case the result is positive, My Cleaning ... without using harmful chemical ingredients. , It was said in ... re-infestation in the campus sparked after a first-grade ...
(Date:5/21/2013)... Clinovo's new “CDISC Standards: Theory and Application” ... June 11th, 2013. The TechTrainings are technical hands-on classes ... step in their professional career. The class will be ... online. , Taught by Sy Truong, President at Meta-Xceed ... Theory and Application” class will give an overview of ...
(Date:5/20/2013)... , May 20, 2013  MiMedx Group, Inc. (NASDAQ: ... marketer of patent protected regenerative biomaterials and bioimplants processed ... secured a revolving line of credit with Bank of ... secured by the Company,s accounts receivable and inventory, allows ... 1, 2014.  The facility will be used for general ...
(Date:5/20/2013)... Biomarkers and Clinigene International are set to unveil their ... 2013 AAPS/ National Biotechnology Conference May 20-22 ... Marina , San Diego, CA. ... company representatives at their collaborative seminar, "Biosimilarity, Immunogenicity and ... 1-2 p.m. in the conference,s Spinnaker Room. ...
Breaking Biology Technology:Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 3Clinovo Launches TechTrainings on CDISC Standards 2Pacific Biomarkers and Clinigene International To Announce Laboratory Solutions for Developers of Biosimilars at 2013 AAPS/ National Biotechnology Conference 2
... Fate Therapeutics, Inc. announced today that it has ... Chief Executive Officer.  Dr. Rastetter served as Chief Executive ... 2003, and as Chairman from May 1996 to November ... in November 2003, Dr. Rastetter served as Executive Chairman ...
... chemical sensors, researchers at the University of Illinois at ... better when the graphene is "worse"more imperfections improved performance. ... would want for transistors, for example," explained Eric Pop, ... a member of the interdisciplinary research team. "Finding that ...
... 2011 Chandler Chicco Companies (CCC), ... leading German healthcare communication firms, Haas & Health ... SanCom Creative Communication Solutions (SanCom CCS) have been ... capability in Germany. The two Eltville, ...
Cached Biology Technology:Fate Therapeutics Announces the Appointment of William H. Rastetter as Chairman of its Board of Directors and Interim CEO 2Fate Therapeutics Announces the Appointment of William H. Rastetter as Chairman of its Board of Directors and Interim CEO 3Imperfections may improve graphene sensors 2Chandler Chicco Companies Acquires Haas & Health Partner Public Relations and SanCom Creative Communication Solutions, Creating Unrivalled Healthcare Communication Capability in Germany 2Chandler Chicco Companies Acquires Haas & Health Partner Public Relations and SanCom Creative Communication Solutions, Creating Unrivalled Healthcare Communication Capability in Germany 3Chandler Chicco Companies Acquires Haas & Health Partner Public Relations and SanCom Creative Communication Solutions, Creating Unrivalled Healthcare Communication Capability in Germany 4Chandler Chicco Companies Acquires Haas & Health Partner Public Relations and SanCom Creative Communication Solutions, Creating Unrivalled Healthcare Communication Capability in Germany 5
Rabbit Anti-Human Secretory Carrier Membrane Protein 2 (SCAMP2 Polyclonal AntibodyOther Sub-Family: not assigned-Other Applications: Western Blot...
... Zeba Desalt Spin Columns contain a proprietary ... offers exceptional desalting and protein-recovery characteristics compared ... as low as 25 g/ml of protein ... and > 95% retention of salts and ...
... This immunoaffinity purified antibody detects an ~185 ... mass of ErbB-2 phosphorylated at tyrosine 1248 ... has been cross adsorbed against the non-phosphorylated ... the non-phosphorylated form of the protein. ...
Mouse Anti-Human Methyl-CpG binding domain protein 2 (MBD2 Monoclonal Antibody Family: Other Applications: Western Blot...
Biology Products: