Navigation Links
What is a laboratory mouse? Jackson, UNC researchers reveal the details
Date:5/29/2011

Bar Harbor, Maine -- Mice and humans share about 95 percent of their genes, and mice are recognized around the world as the leading experimental model for studying human biology and disease. But, says Jackson Laboratory Professor Gary Churchill, Ph.D., researchers can learn even more "now that we really know what a laboratory mouse is, genetically speaking."

Churchill and Fernando Pardo-Manuel de Villena, Ph.D., of the University of North Carolina, Chapel Hill, leading an international research team, created a genome-wide, high-resolution map of most of the inbred mouse strains used today. Their conclusion, published in Nature Genetics: Most of the mice in use today represent only limited genetic diversity, which could be significantly expanded with the addition of more wild mouse populations.

The current array of laboratory mouse strains is the result of more than 100 years of selective breeding. In the early 20th century, America's first mammalian geneticists, including Jackson Laboratory founder Clarence Cook Little, sought to understand the genetic processes that lead to cancer and other diseases. Mice were the natural experimental choice as they breed quickly and prolifically and are small and easy to keep.

Lacking the tools of molecular genetics, those early scientists started by tracking the inheritance of physical traits such as coat color. A valuable source of diverse-looking mouse populations were breeders of "fancy mice," a popular hobby in Victorian and Edwardian England and America as well as for centuries in Asia.

In their paper, Churchill and Pardo-Manuel de Villena report that "classical laboratory strains are derived from a few fancy mice with limited haplotype diversity." In contrast, strains that were derived from wild-caught mice "represent a deep reservoir of genetic diversity," they write.

The team created an online tool, the Mouse Phylogeny Viewer, for the research community to access complete genomic data on 162 mouse strains. "The viewer provides scientists with a visual tool where they can actually go and look at the genome of the mouse strains they are using or considering, compare the differences and similarities between strains and select the ones most likely to provide the basis for experimental results that can be more effectively extrapolated to the diverse human population," said Pardo-Manuel de Villena.

"As scientists use this resource to find ways to prevent and treat the genetic changes that cause cancer, heart disease, and a host of other ailments, the diversity of our lab experiments should be much easier to translate to humans," he noted.

Churchill and Pardo-Manuel de Villena have been working for almost a decade with collaborators around the world to expand the genetic diversity of the laboratory mouse. In 2004 they launched the Collaborative Cross, a project to interbreed eight different strains--five of the classic inbred strains and three wild-derived strains. In 2009 Churchill's lab started the Diversity Outbred mouse population with breeding stock selected from the Collaborative Cross project.

The research team estimates that the standard laboratory mouse strains carry about 12 million single nucleotide polymorphisms (SNPs), single-letter variations in the A, C, G or T bases of DNA. The Collaborative Cross mice deliver a whopping 45 million SNPs, as much as four times the genetic variation in the human population. "All these variants give us a lot more handles into understanding the genome," Churchill says.

"This work creates a remarkable foundation for understanding the genetics of the laboratory mouse, a critical model for studying human health," said James Anderson, Ph.D., who oversees bioinformatics grants at the National Institutes of Health. "Knowledge of the ancestry of the many strains of this invaluable model vertebrate will not only inform future experimentation but will allow a retrospective analysis of the huge amounts of data already collected."


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory March 2011
2. Story tips from the Department of Energys Oak Ridge National Laboratory January 2011
3. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
4. Developmental biology is focus of new volume in laboratory manual series on imaging
5. Pacific Northwest National Laboratorys 2010 AGU tip sheet
6. Story tips from the Department of Energys Oak Ridge National Laboratory -- December 2010
7. First volume of new laboratory manual series on imaging is released
8. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
9. Story tips from the US Department of Energys Oak Ridge National Laboratory October 2010
10. Cold Spring Harbor Laboratory neuroscientist awarded Transformative NIH research grant
11. UMCES Chesapeake Biological Laboratory to rebuild historic research pier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2016)... y TORONTO , 19 de diciembre de 2016 ... Inc. que permitirá el desarrollo acelerado de MSC-1, un anticuerpo humanizado ... tipos de tumor en 2017, con múltiples sitios previstos a lo ... ... objetivo en el factor inhibidor de leucemia (LIF), una citoquina pleiotrópica ...
(Date:12/15/2016)... 15, 2016   WaferGen Bio-systems, Inc. (NASDAQ: ... company, announced today that on December 13, 2016, it ... The Nasdaq Stock Market LLC which acknowledged that, as ... WaferGen,s common stock had been at $1.00 or greater ... compliance with Listing Rule 5550(a)(2) of the Nasdaq Stock ...
(Date:12/12/2016)... Dec. 12, 2016  Researchers at Trinity College, ... graphene by combining the material with Silly Putty. The ... pressure detector able to sense pulse, blood pressure, ... spider.  The research team,s findings ... read here:  http://science.sciencemag.org/content/354/6317/1257 ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... MA (PRWEB) , ... January 17, 2017 , ... ... the completely re-engineered Drug Safety Technology Consortium™ (SafeTEC™), $3 million in investment towards ... validating these new tools and assays, and their applicability in drug safety assessment, ...
(Date:1/16/2017)... ... January 16, 2017 , ... Appellate Court ... decision on the appeal filed by India-based Dishman Pharmaceutical & Chemical Ltd. company ... DPCL and one of its Dishman Group’s 100% wholly owned New Jersey-based subsidiary ...
(Date:1/14/2017)...  The Alliance for Safe Biologic Medicines (ASBM) today ... final guidance on biologic naming: We ... the importance of distinct naming for all biologics, including ... biosimilars will bring to patients, including new treatment options ... of the Guidance dealing with suffix design remains at ...
(Date:1/13/2017)... ... January 13, 2017 , ... FireflySci, in response to several ... new solutions for measurements where traditional cuvette applications are not convenient. For instance, ... oddly-shaped sample that would not fit into a typical cuvette inside a spectrophotometer. ...
Breaking Biology Technology: