Navigation Links
What is a laboratory mouse? Jackson, UNC researchers reveal the details
Date:5/29/2011

Bar Harbor, Maine -- Mice and humans share about 95 percent of their genes, and mice are recognized around the world as the leading experimental model for studying human biology and disease. But, says Jackson Laboratory Professor Gary Churchill, Ph.D., researchers can learn even more "now that we really know what a laboratory mouse is, genetically speaking."

Churchill and Fernando Pardo-Manuel de Villena, Ph.D., of the University of North Carolina, Chapel Hill, leading an international research team, created a genome-wide, high-resolution map of most of the inbred mouse strains used today. Their conclusion, published in Nature Genetics: Most of the mice in use today represent only limited genetic diversity, which could be significantly expanded with the addition of more wild mouse populations.

The current array of laboratory mouse strains is the result of more than 100 years of selective breeding. In the early 20th century, America's first mammalian geneticists, including Jackson Laboratory founder Clarence Cook Little, sought to understand the genetic processes that lead to cancer and other diseases. Mice were the natural experimental choice as they breed quickly and prolifically and are small and easy to keep.

Lacking the tools of molecular genetics, those early scientists started by tracking the inheritance of physical traits such as coat color. A valuable source of diverse-looking mouse populations were breeders of "fancy mice," a popular hobby in Victorian and Edwardian England and America as well as for centuries in Asia.

In their paper, Churchill and Pardo-Manuel de Villena report that "classical laboratory strains are derived from a few fancy mice with limited haplotype diversity." In contrast, strains that were derived from wild-caught mice "represent a deep reservoir of genetic diversity," they write.

The team created an online tool, the Mouse Phylogeny Viewer, for the research community to acces
'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory March 2011
2. Story tips from the Department of Energys Oak Ridge National Laboratory January 2011
3. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
4. Developmental biology is focus of new volume in laboratory manual series on imaging
5. Pacific Northwest National Laboratorys 2010 AGU tip sheet
6. Story tips from the Department of Energys Oak Ridge National Laboratory -- December 2010
7. First volume of new laboratory manual series on imaging is released
8. German-Russian Otto Schmidt Laboratory in St. Petersburg funded for another 3 years
9. Story tips from the US Department of Energys Oak Ridge National Laboratory October 2010
10. Cold Spring Harbor Laboratory neuroscientist awarded Transformative NIH research grant
11. UMCES Chesapeake Biological Laboratory to rebuild historic research pier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... of Texas at Arlington research team says recently identified ... their lab could open doors for homeland security and ... in the Oct. 1 issue of Optics Letters ... co-authors describe a new method to fabricate transparent nanoscintillators ... until a transparent ceramic is formed. A scintillator ...
(Date:9/29/2014)... University have concluded that nondigestible compounds in apples ... prevent disorders associated with obesity. The study, thought ... in apple cultivars grown in the Pacific Northwest, ... Food Chemistry ., "We know that, in ... nondigestible compounds but there are differences in varieties," ...
(Date:9/29/2014)... scientists have found compounds that boost liver detoxification enzymes ... unlikely placethe crushed seeds left after oil extraction from ... bioactive compounds in Camelina sativa seed, also ... of phytochemicals that work together synergistically far better than ... nutritional supplement because its bioactive ingredients increase the liver,s ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2New way to detox? 'Gold of Pleasure' oilseed boosts liver detoxification enzymes 2
... Society for Microbiology (ASM) sanofi-aventis ICAAC Award will ... of Oxford, United Kingdom and Mahidol University, Bangkok, ... Units, Bangkok. Supported by sanofi-aventis, the award ... of new agents, investigation of antimicrobial action or ...
... for Microbiology (ASM) ICAAC Young Investigator Award will be ... Texas A & M University, College Station. Sponsored by ... scientists for research excellence in microbiology and infectious diseases. ... pathogen, has a defined sexual cycle with two mating ...
... -- Engineers at Ohio State University have found a way ... someday replace gasoline in automobiles. The process improves on ... tank. Normally, bacteria could only produce a certain amount ... every liter of water in the tank -- before the ...
Cached Biology News:Researchers boost production of biofuel that could replace gasoline 2
(Date:9/30/2014)... 30, 2014 The custom stainless steel ... Product Show 2014. The Boston Area Chapter of ISPE ... annual, day-long event for Wed., Oct. 1 at Gillette ... be the largest in ISPE Boston’s long history, with ... 3,000 attendees expected. , HOLLOWAY AMERICA President David ...
(Date:9/30/2014)... UFP Technologies, a producer of ... recently introduced a custom insulated shipping container to ... new insulated shipper solves the issue of temperature ... Technologies’ BioShell is a universal storage container which ... and shipping. The insulated shipper keeps frozen BioShells ...
(Date:9/29/2014)... forefront of diagnostics today, with imaging techniques like ... and NMR (nuclear magnetic resonance) increasing steeply over ... image resolution and quality still limit these techniques ... solution is hyperpolarization, which involves injecting the patient ... following the distribution and fate of specific molecules ...
(Date:9/29/2014)... in food security, emerging diseases and biodiversity loss ... online in Science Express that was ... Arizona College of Agriculture and Life Sciences. , ... nine scientists has reviewed progress in addressing a ... environmental management using approaches that consider evolutionary histories ...
Breaking Biology Technology:HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3
... 4 Wyeth (NYSE: WYE ),announced today ... 2008 Global,Pharmaceutical, Biotechnology and Medical Device Conference on ... Presenting for Wyeth will be,Geno Germano, President, U.S. ... presentation will be webcast live for investors at, ...
... Technologies, Inc.,(Nasdaq: EMIS ), a biopharmaceutical company that ... using its eligen(R) technology,today announced that the company will ... 12, 2008 at the Waldorf Astoria Hotel in New ... Officer of,Emisphere, will present for the company at 2:45 ...
... Calif., Feb. 4 AMDL, Inc. (Amex:,ADL), ... Shenzhen,Jiangxi, and Jilin, China, through its wholly ... international biopharma company that,together with Jade, engages ... pharmaceutical, health care and diagnostic products. The,Company ...
Cached Biology Technology:Wyeth to Present at the Merrill Lynch 2008 Global Pharmaceutical, Biotechnology and Medical Device Conference 2Emisphere Technologies to Present at BIO CEO & Investor Conference on February 12 2AMDL Receives a Significant Updated Appraisal of Its JJB China Production Facilities 2
MiniCycler thermal cycler with Hot Bonnet heated lid, holds 25x0.2ml tubes...
... Leu-CMK FLISP Assay with SR-101 ... Em=620 nm) • Accurately measure serine ... or permeabilization • B-Bridge's FLISP Kits ... serine proteases (FLISPs) to measure chymotrypsin-like ...
... conjunction with your existing apoptosis protocols. Grow your ... your existing procedure (also reserve a non-induced population ... have induced apoptosis in your cells, add the ... the cells for an additional 15 minutes. During ...
... The biolistic PDS-1000 He system ... gas to accelerate micron-size nucleic acid-coated ... necessary to transfect cells, tissues, or ... the cell surface. The system includes ...
Biology Products: