Navigation Links
'Western' diet linked to increased risk of colon cancer recurrence
Date:8/14/2007

BOSTONColon cancer patients who eat a diet high in red meat, fatty products, refined grains, and desserts a so-called Western diet may be increasing their chance of disease relapse and early death, report researchers at Dana-Farber Cancer Institute.

The study, published in the Aug. 15 issue of the Journal of the American Medical Association, involved 1,009 patients with stage III colon cancer that has been treated with both surgery and chemotherapy. Stage III colon cancer is characterized as being localized to the large bowel area with cancer cells in the lymph nodes near the tumor. The investigators found that those who most closely followed a Western diet were three-and-a-half times more likely to have colon cancer recur than those whose diets were least Western-like.

We know from previous research that diet and lifestyle influence peoples risk of developing colon cancer, says the studys lead author, Jeffrey Meyerhardt, MD, MPH, of Dana-Farber. This is the first large observation study to focus on the role of diet in recurrence of the disease. Our results suggest that people treated for locally advanced colon cancer can actively improve their odds of survival by their dietary choices.

The participants, who were enrolled in a large, phase III clinical trial sponsored by the National Cancer Institute of follow-up (adjuvant) chemotherapy, had their tumors surgically removed within the two months prior to enrolling in the study. They reported their dietary intake on specially designed questionnaires at two different time points during the period they were receiving chemotherapy and six months after the completion of chemotherapy.

Meyerhardt and his colleagues identified two major dietary trends within the group: A prudent pattern characterized by high intakes of fruits and vegetables, poultry, and fish, and a Western pattern characterized by high amounts of red and processed meats, sweets and desserts, French fries, and refined grains. Participants didnt fall neatly into one category or the other, but were scored in each by how closely they matched the Western and prudent models.

The survival benefit for those whose diets least resembled the Western pattern held true even after researchers controlled for factors such as gender, age, body mass, degree of cancer spread to lymph nodes, and physical activity level. Investigators do not know why such a diet is associated with a poorer outcome, but speculate that it may be related to increased insulin levels and insulin-like growth factors. Insulin and related growth factors have been linked to the formation and growth of some types of tumors.

In contrast to the negative effect of a Western diet, researchers found that following a prudent-pattern diet did not significantly influence cancer recurrence or mortality. The message is that patients in this category can improve their prospects by avoiding certain foods, comments Meyerhardt, who is also an assistant professor of medicine at Harvard Medical School. Meyerhardt adds that more research is needed to better understand what components of diet are most responsible for the study findings, and why.


'/>"/>
Contact: Abigail Tomlinson
abigail_tomlinson@dfci.harvard.edu
617-632-5379
Dana-Farber Cancer Institute
Source:Eurekalert

Related biology news :

1. UT Southwestern researchers discover master switch in cell death
2. UT Southwestern researchers develop screening test for cells that activate immune system
3. UT Southwestern researchers unravel control of growing blood vessels
4. Scientists discover dozens of new species in Lost World of western New Guinea
5. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
6. UT Southwestern researchers find gene mutation that leads to broken hearts
7. Case Western Reserve University researchers find protein associated with brain cell death
8. Study finds mercury prevalent in many western fish
9. Napoleons mysterious death unmasked, UT Southwestern researcher says
10. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
11. New SARS Protein Linked To Important Cell Doorway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring announced that ... has secured the final acceptance by all three ... Access Systems (MAS) installed. Furthermore, Securus will have ... installed by October, 2016. MAS distinguishes between legitimate ...
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/9/2016)... Finland , June 9, 2016 ... National Police deploy Teleste,s video security solution to ensure the ... France during the major tournament ... data communications systems and services, announced today that its video ... Prefecture to back up public safety across the ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest features ... will also be presenting a scientific poster on Disrupting Clinical Trials in The ...
(Date:6/23/2016)... PUNE, India , June 23, 2016 /PRNewswire/ ... culture media market research report to its pharmaceuticals ... company profiles, product details and much more. ... market spread across 151 pages, profiling 15 companies ... now available at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . ...
Breaking Biology Technology: