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West Nile virus' spread through nerve cells linked to serious complication
Date:10/18/2007

as cleared the infection in the skin, a small amount of virus may already be following the nerve back to the spinal cord. Unless you have a robust antibody response, you're probably not going to clear that fast enough, and you might get paralysis."

When scientists injected a therapeutic antibody the day after the viral injection, it blocked both encephalitis and paralysis. The antibody, developed by Washington University and Macrogenics Inc., has been licensed to Macrogenics for commercial development and is in early clinical trials in humans.

"We already knew the antibody could block encephalitis," notes Diamond, in whose laboratory the antibody was originally developed. "The levels of antibody in the central nervous system are relatively low compared to the rest of the body, but they're still high enough to block paralysis."

Diamond plans follow-up studies to see how long after infection the antibodies can be injected and still retain their protective effect against paralysis. He also plans to test whether the virus is sitting back and passively letting the nerve cell move it along or actively pushing itself forward by manipulating nerve cell physiology.

Diamond and co-author John D. Morrey have a financial interest in the antibody that is regulated in accordance with Washington University's conflict-of-interest policies.


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Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University in St. Louis
Source:Eurekalert

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