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Weizmann Institute scientists discover how cancer cells survive a chemotherapy drug
Date:1/28/2009

ey acted in one of two ways.

The team then asked whether any of the bimodal proteins they had identified were those that occasionally promote cell survival. They found two molecules that seem to fit the bill. One of them, known by the letters DDX5, is a multitasking protein that, among other things, plays a role in initiating the production of other proteins. The other, RFC1, also plays varied roles, including directing the repair of damaged DNA. When the researchers blocked the production of these proteins in the cancer cells, the drug became much more efficient at wiping out the growth.

Cohen: 'This method gave us tremendous insight into how a cell responds to a drug. By conducting an unbiased study we started with no preconceived notions of which proteins were involved we were able to pinpoint possible new drug targets and to see how certain activities might boost the effectiveness of current drugs.'


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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

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