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Weill Cornell team discovers how brain's own tPA helps regulate blood flow to neurons
Date:1/17/2008

nNOS activity and NO production goes on inside the neuron, Dr. Iadecola points out. "That means there's some kind of biochemical chain connecting external tPA to these internal mechanisms," he says. "Identifying the key players in that pathway will be a key part of our research going forward."

The new discoveries will have exciting implications for brain research, he says.

"More and more, we are realizing that alterations in the availability of blood to brain cells is crucial to stroke and post-stroke recovery, and in the debilitating loss of neuronal function that underlies Alzheimer's disease and other dementias," Dr. Iadecola says.

"It is possible that drugs or other interventions that manipulate the brain's natural supply of tPA could help preserve neurological function after stroke or Alzheimer's, or even help reverse some of the damage," he says. "Those types of treatments are still a long way off, but our new understanding how tPA works to keep neurons healthy and active is a crucial first step in that research."


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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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