Navigation Links
Weill Cornell team discovers how brain's own tPA helps regulate blood flow to neurons
Date:1/17/2008

was the finding from recent studies that tPA somehow modulates the activity of a protein lying on the surface of neurons called the NMDA receptor," Dr. Iadecola explains. "This receptor serves as a gateway of communication between adjoining neurons, with glutamate being the 'currency' of exchange. Fluctuating levels of tPA seemed to influence just how much of that currency got through as brain cells became more or less active."

Exploring this mechanism further, Dr. Iadecola's team utilized a genetically engineered "knockout" mouse that lacked neuronal tPA. They tweaked the mouse's whiskers and watched blood flow in the area of the rodent's brain linked to whisker sensitivity.

"In the knockout mouse, blood flow in that area did not change as much upon whisker stimulation -- confirming that tPA is necessary to boosting local blood flow," Dr. Iadecola says.

But how was tPA working, exactly? The prevailing theory -- that the enzyme impacted directly on the NMDA receptor -- was quickly proven wrong. "We found that tPA was not acting as any kind of direct 'choke' on the NMDA receptor to allow more or less glutamate into the cell," says Eduardo Gallo, a graduate student in the Department of Neurology and Neuroscience, who played a key role in the study.

So, the team looked elsewhere at other rate-limiting mechanisms that might explain tPA's effects.

"One of the end-products of NMDA receptor activity is nitric oxide (NO), a powerful vasodilator," Gallo notes. "In our experiments, we discovered that tPA helps control how much NO can be made by activation of the NMDA receptor. TPA does so by boosting the ability of neuronal nitric oxide synthase (nNOS) -- an enzyme -- to produce NO. More tPA means more active nitric oxide synthase -- and more of this enzyme means more vessel-widening NO. The end result: a localized boost in blood flow to brain cells."

Questions remain, however. TPA exists outside the brain cell, but the
'/>"/>

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. $13 million federal grant for research into vascular disease awarded to Weill Cornell
2. 2 federal public health grants awarded to Weill Cornell Medical College
3. Drug aimed at 2 bioterror agents blocks live viral infection, Weill Cornell team reports
4. Cornell patents a pink lily look-alike that blooms all summer long
5. Cornell researchers prove how plants transport sugars
6. Cornell researcher seeks clues to how tuberculosis infects cells
7. Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots
8. First symposium of UN University-Cornell Africa Series to be held at UN
9. Cornell will host the Northeast Biofuel Summit, Nov. 11-13
10. CU-Boulder team discovers first ancient manioc fields in Americas
11. deCODE discovers cause of major subtype of glaucoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
(Date:12/10/2014)... 9, 2014     ...   Jifflenow, a ... solutions for business-to-business (B2B) events, today announced a ... mobile near-field communication (NFC), Bluetooth low energy (BLE), ... http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate its ...
(Date:12/5/2014)... -- Tute Genomics, a leader in cloud-based solutions for genome ... led by UK-based Eurovestech. Peak Ventures and a number ... "We are at a pivotal time in ... seeks new approaches for the diagnosis, treatment and prevention ... and CEO of Tute Genomics. "One of the main ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... say they have discovered a cause-and-effect relationship between ... believed to be independent of one another. ... better drugs to treat the cognitive dysfunction associated ... ,Researchers have long studied the role played in ...
... Rice University and Lockheed Martin reported this month that ... from a single silicon wafer. The process uses simple ... lithium-ion batteries, laying the groundwork for longer-lasting, more powerful ... vehicles. The work led by Sibani Lisa Biswal, ...
... up their arms, clench their fists and grimace after a ... the same across cultures, a new study suggests. New findings ... Human Behavior suggest this victory pose signals feelings of ... "We found that displays of triumph include different behaviors ...
Cached Biology News:Johns Hopkins researchers link 2 biological risk factors for schizophrenia 2Toughened silicon sponges may make tenacious batteries 2Victory stance may be a universal gesture of triumph -- not pride -- study suggests 2
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
(Date:12/24/2014)... Dec. 23, 2014 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today that investors including Oracle ... Fund LLC and several Vermillion directors have agreed ... of Vermillion,s common stock and warrants to purchase ... private placement.  Under the terms ...
(Date:12/24/2014)... 2014 Sigma-Aldrich Corporation (NASDAQ: ... under the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) ... 22, 2014, thereby completing the U.S. HSR Act ... of the Company by Merck KGaA, Darmstadt, Germany.  ... condition to closing the transaction, which remains subject ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  NeuroLifeSciences ... of mazindol in children with attention deficit/hyperactivity disorder published ... 2014 . The paper, titled "Pilot ... deficit/hyperactivity disorder" ( Konofal et al, Drug ... 2014 ) shows that mazindol might be an ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... - FDA Targets January 11, 2008 as Action Date, ... SPPI ) today announced that the amendment to,the ... LFA),for injection has been accepted by the U.S. Food ... 2008 as its action date regarding,the approval of the ...
... Asset Exchange Agreement, COPENHAGEN, September 13 ... an asset exchange agreement with,Medarex, Inc. Under the ... to HuMax-Inflam(TM)/MDX-018, which targets IL-8, and Medarex will,receive ... Genmab and,Medarex will release to each other all ...
... UPTON, NY Scientists at the U.S. Department of ... for controlling the self-assembly of nanometer and micrometer-sized particles. ... a particles surface, can be used to manipulate the ... of numerous materials that may be of interest ...
Cached Biology Technology:FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 2FDA Accepts ISO-Vorin(TM) New Drug Application Amendment Submitted by Spectrum Pharmaceuticals 3Genmab Announces Asset Exchange Agreement 2New DNA-based technique for assembly of nano- and micro-sized particles 2
... covers can be used with ... covers for stacking of covered ... for use with automated systems ... and non-ridged, are available for ...
... modular, computer controlled pre-amplifier suitable for a ... electrode input for recording physiological signal such ... a transducer input for use with a ... Additional options include a stimulus artefact clamp ...
SYBR Green Nucleic Acid Dye...
... 384 cap mat made from an inert ... Features 384 split septum caps ... AB-1056) Suitable for PCR when used in ... cyclers Pierceable with standard pipetting equipment ...
Biology Products: