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Weill Cornell science briefs June/July 2008
Date:7/17/2008

"It takes far too long for the vesicles to move from all the way in the cell body to another cell. These vesicles are made in New York and slowly transported to the cell's terminal end, but some are made right in Boston for immediate use." Dr. Ryan hopes that by understanding the mechanics of the cellular trafficking machine, he and other scientists will ultimately be able to identify and repair numerous neurologic malfunctions.

News About Inflammatory Bowel Disease, Crohn's Disease:

Stem Cells Heal Chronic Inflammation in the Gut
May Help Restore Immune System to Normal Function for Crohn's Disease

Stem cells are being studied at NewYork-Presbyterian/Weill Cornell to heal the gut in subjects suffering from Crohn's disease. Physician-scientists believe that these cells might help to restore the ability of the immune system to control inflammation by secreting anti-inflammatory proteins into the digestive tract, allowing for regeneration of tissue and prevention of scar tissue. It is believed that Crohn's disease results from a malfunctioned immune response, leading to uncontrolled inflammation in the tissues of the intestine. Diarrhea, painful cramping, blood in stool, ulcers and other wounds in the digestive tract are all possible symptoms of the disease.

Patients who have previously failed to benefit from medications for Crohn's disease are enrolled in the trial to test the safety and efficacy of the procedure. Each subject receives four infusions -- intravenous transplantation -- of mesenchymal stem cells, which are universally compatible in all people, like type-O blood.

For more information: Please contact Cynthia Cabral at 212-746-5118.

Drug for Treatment of Inflammatory Bowel Disease
New Formula Allows for Greater Absorption, Fewer Doses

Physician-scientists from NewYork-Presbyterian/Weill Cornell, involved in clinical trials for a new drug for those
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Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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