Navigation Links
Weighing particles at the attogram scale
Date:1/13/2014

ny silicon cantilever that vibrates inside a vacuum cavity. As cells or particles flow through the channel, one at a time, their mass slightly alters the cantilever's vibration frequency. The mass of the particle can be calculated from that change in frequency.

To make the device sensitive to smaller masses, the researchers had to shrink the size of the cantilever, which behaves much like a diving board, Olcum says. When a diver bounces at the end of a diving board, it vibrates with a very large amplitude and low frequency. When the diver plunges into the water, the board begins to vibrate much faster because the total mass of the board has dropped considerably.

To measure smaller masses, a smaller "diving board" is required. "If you're measuring nanoparticles with a large cantilever, it's like having a huge diving board with a tiny fly on it. When the fly jumps off, you don't notice any difference. That's why we had to make very tiny diving boards," Olcum says.

In a previous study, researchers in Manalis' lab built a 50-micron cantilever about one-tenth the size of the cantilever used for measuring cells. That system, known as a suspended nanochannel resonator (SNR), was able to weigh particles as light as 77 attograms at a rate of a particle or two per second.

The cantilever in the new version of the SNR device is 22.5 microns long, and the channel that runs across it is 1 micron wide and 400 nanometers deep. This miniaturization makes the system more sensitive because it increases the cantilever's vibration frequency. At higher frequencies, the cantilever is more responsive to smaller changes in mass.

The researchers got another boost in resolution by switching the source for the cantilever's vibration from an electrostatic to a piezoelectric excitation, which produces a larger amplitude and, in turn, decreases the impact of spurious vibrations that interfere with the signal they are trying to measure.

With t
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Weighing molecules 1 at a time
2. A magnetic nanoparticles-based method for DNA extraction from the saliva after stroke
3. Thousands of new particles in workplaces despite large knowledge gap
4. Ultrasound, nanoparticles may help diabetics avoid the needle
5. Nanoparticles can overcome drug resistance in breast cancer cells
6. Making complex nanoparticles easily reproducible
7. Gold nanoparticles give an edge in recycling CO2
8. Stealth nanoparticles lower drug-resistant tumors defenses
9. Researchers figure out why gold nanoparticles can penetrate cell walls
10. Nanoparticles, pH phoresis could improve cancer drug delivery
11. MU researchers develop radioactive nanoparticles that target cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/10/2015)... Colo. , March 10, 2015 ... Flight "Personalized Medicine in Human Space ... and Thomas J. Goodwin , Ph.D. was recently ... of the past two years. Specifically, "Personalized ... most downloaded scientific papers published in 2013 and 2014 ...
(Date:3/3/2015)... FOREST, Calif. , March 3, 2015 ... the leading provider of advanced cryogenic logistics ... markets including immunotherapies, stem cells, cell lines, ... and reproductive medicine, today announced the expansion ... Cancer Research Centers, ("Fred Hutch") Clinical ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
... is emerging for how important it is for pregnant women ... every day seem to have children who are less likely ... study from the Sahlgrenska Academy at the University of ... with Linkping University, which is conducting a population study called ...
... awarded $6.27 million to develop an interactive software system ... home. The funding, which covers a two-year period, includes ... Projects Agency-Energy (ARPA-E), About $1.28 million in matching grants ... Energy Commission. The Stanford team will focus on ...
... Origin of Species 150 years ago, he deliberately avoided the ... mention of the ,Creator, in the last paragraph of the ... commit on the matter. An international team, led by Juli ... idea and shows that the British naturalist did explain in ...
Cached Biology News:Vegetables can protect unborn child against diabetes 2Stanford researchers awarded $6.27 million to study energy efficiency and human behavior 2Charles Darwin really did have advanced ideas about the origin of life 2
(Date:4/1/2015)... NJ (PRWEB) April 01, 2015 Earlier ... BioNJ, a vibrant life sciences industry association that represents ... 400 members. , Jonathan Parker, AJO’s Vice President ... Gala Dinner in February, an event that attracted over ... highlights, Don Wright, a 73 year old cancer survivor ...
(Date:3/31/2015)... 2015 CytoSorbents Corporation (NASDAQ CM: CTSO), ... to treat critically-ill and cardiac surgery patients in ... reports financial results for the fiscal year ending ... product revenues were a record $3.1M, an increase ... revenues of $0.8M Highlights for the Year Ending ...
(Date:3/31/2015)... Richmond, KY (PRWEB) March 31, 2015 ... top 50 schools for online bachelor’s of criminal ... committed to connecting people to inspiring ideas and ... in an e-mail to the University. We are ... Kentucky University.” , This is the site’s ...
(Date:3/31/2015)... , March 31, 2015  Sonoa Health, a health ... , has developed a world-first consumer health portal, Health&, ... prescriptions, wearable devices and more. Today, the ... as its CEO, who brings to the table more ... which has included working closely with the biggest names ...
Breaking Biology Technology:HR Consulting Firm, A.J. O'Connor Associates Joins BioNJ – The Vibrant 400 Member Strong Life Sciences Industry Association - and Attends its Annual Dinner 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 2Investment Banker Appointed CEO of Australian Health Tech Start-Up 3
... Technology, Inc. announced today that Jim Bullock has been ... company.  Before joining Zyga Technology, Jim was President and ... Boston Scientific.  Prior to Atritech, Jim was President and ... St. Jude Medical.  (Logo: http://photos.prnewswire.com/prnh/20110118/CG30384LOGO ...
... BEIJING, January 16, 2012 Elsevier, ... information products and services, announced today that its ... management, NursingChina , is now available online. ... online reference product available in China, featuring skills ...
... in a wide variety of applications from food ... applications. Thermal analysis is routinely used to analyze ... to use nanostructured materials has made bulk techniques ... force microscope-based technique called nanoscale thermal analysis (nanoTA) ...
Cached Biology Technology:Zyga Technology, Inc. Announces the Appointment of Jim Bullock as President and CEO 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 2Elsevier Launches Bilingual International Nursing Skill Training and Management Platform: NursingChina.com 3Magnetic actuation enables nanoscale thermal analysis 2
... Hypothetical protein FLJ20644, likely ortholog of ... Protein Accession #: NP_060387.1 gi ... Definition: chromosome 14 open reading frame ... gene g4-1 [Homo sapiens] Locus ...
1/4" to 1/8" Adapter for Reflectance Probe Holder...
ACAT-1 (H-125)...
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
Biology Products: