Navigation Links
Weighing particles at the attogram scale
Date:1/13/2014

CAMBRIDGE, MA -- MIT engineers have devised a way to measure the mass of particles with a resolution better than an attogram one millionth of a trillionth of a gram. Weighing these tiny particles, including both synthetic nanoparticles and biological components of cells, could help researchers better understand their composition and function.

The system builds on a technology previously developed by Scott Manalis, an MIT professor of biological and mechanical engineering, to weigh larger particles, such as cells. This system, known as a suspended microchannel resonator (SMR), measures the particles' mass as they flow through a narrow channel.

By shrinking the size of the entire system, the researchers were able to boost its resolution to 0.85 attograms more than a 30-fold improvement over the previous generation of the device.

"Now we can weigh small viruses, extracellular vesicles, and most of the engineered nanoparticles that are being used for nanomedicine," says Selim Olcum, a postdoc in Manalis' lab and one of the lead authors of a paper describing the system in this week's issue of the Proceedings of the National Academy of Sciences.

Graduate student Nathan Cermak is also a lead author of the paper, and Manalis, a member of MIT's Koch Institute for Integrative Cancer Research, is the paper's senior author. Researchers from the labs of MIT professors and Koch Institute members Angela Belcher and Sangeeta Bhatia also contributed to the study.

A small sensor for small particles

Manalis first developed the SMR system in 2007 to measure the mass of living cells, as well as particles as small as a femtogram (one quadrillionth of a gram, or 1,000 attograms). Since then, his lab has used the device to track cell growth over time, measure cell density, and measure other physical properties, such as stiffness.

The original mass sensor consists of a fluid-filled microchannel etched in a ti
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Weighing molecules 1 at a time
2. A magnetic nanoparticles-based method for DNA extraction from the saliva after stroke
3. Thousands of new particles in workplaces despite large knowledge gap
4. Ultrasound, nanoparticles may help diabetics avoid the needle
5. Nanoparticles can overcome drug resistance in breast cancer cells
6. Making complex nanoparticles easily reproducible
7. Gold nanoparticles give an edge in recycling CO2
8. Stealth nanoparticles lower drug-resistant tumors defenses
9. Researchers figure out why gold nanoparticles can penetrate cell walls
10. Nanoparticles, pH phoresis could improve cancer drug delivery
11. MU researchers develop radioactive nanoparticles that target cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Nine researchers from Beth Israel Deaconess Medical Center (BIDMC ... World,s Most Influential Scientific Minds 2014," a comprehensive ... a web resource for science metrics and research performance ... the most influential "are performing and publishing work that ... their science," according to a Thomson Reuters statement. Researchers ...
(Date:8/21/2014)... heard of the water window? It consists of radiations ... not absorbed by the water in biological tissues. New ... coherent radiations within the water window. These could be ... high-contrast image of the biological samples or to be ... identifies the physical mechanism needed to efficiently generate the ...
(Date:8/21/2014)... connectors, designed by an international standards process, will be ... to an invited review published in the OnlineFirst version ... ), the official journal of the American Society for ... greatly reduce the occurrence of misconnection that can be ... which are used to join medical devices, components, and ...
Breaking Biology News(10 mins):BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2
... the ancestors of such marine creatures as clams, sand ... 144 million years ago with no clear trend afterwards, ... previous work showing dramatic increases beginning 248 million years ... of the time periods in the past are analogies ...
... with you may actually influence how you see the ... mental imagery--what we see with the "mind,s eye"--directly impacts ... online June 26 by the journal Current Biology ... short-term memory trace that can bias future perception," Joel ...
... at UCLA have solved the structure of a class ... pump glucose into cells. These transport proteins are used ... therapy, saving the lives of millions of children each ... development of new drugs designed to treat patients with ...
Cached Biology News:Ancient marine invertebrate diversity less explosive than thought 2Ancient marine invertebrate diversity less explosive than thought 3'Mind's eye' influences visual perception 2'Mind's eye' influences visual perception 3UCLA researchers clarify function of glucose transport molecule 2
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Not long ... E&L studies should be performed late in the development ... known. But current regulatory trends suggest that, like many ... the rise. In recent years, multiple drug sponsors have ... or address specific questions during phase I/II. It’s not ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 ... released today including improvements to the enterprise replication ... connectors for Lucene, SOLR and Elasticsearch. This release ... this high performance triplestore – GraphDB™ was formerly ... in deploying the only mature enterprise resilient RDF ...
(Date:8/19/2014)... DANVILLE, Pa. , Aug. 19, 2014 ... C has been nominated for a Centers for Disease ... to addressing a major public health concern. ... Health System, is one of a team of researchers ... (CDC) Charles C. Shepard Science Award for Data Methods ...
Breaking Biology Technology:New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... Senomyx, Inc.,(Nasdaq: SNMX ), a leading ... develop novel flavor ingredients for the food, beverage ... Founder,University of California, San Diego Professor and Howard ... been awarded the Nobel,Prize in Chemistry for 2008 ...
... Del., Oct. 10 AstraZeneca (NYSE:,AZN) today announced ... has,approved once-daily SEROQUEL XR(R) (quetiapine fumarate) Extended-Release,Tablets for ... with,bipolar disorder, the manic and mixed episodes associated ... bipolar I disorder as adjunctive,therapy to lithium or ...
... Oct. 10 Micell Technologies announced,today that ... Micell Rapid Absorption,Polymer DES System" during the ... (TCT) conference in Washington,DC, on October 13, ... studies, utilizes a bioresorbable polymer coating that,delivers ...
Cached Biology Technology:SENOMYX CO-FOUNDER AND SCIENTIFIC ADVISORY BOARD MEMBER ROGER TSIEN, PH.D., AWARDED NOBEL PRIZE IN CHEMISTRY 2FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 2FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 3FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 4FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 5FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 6FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 7FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 8FDA Approves AstraZeneca's SEROQUEL XR(R) for the Treatment of Bipolar Depression and Bipolar Mania 9
RABBIT ANTI HUMAN ATR (aa2122-2380) Immunogen: Human ATR peptide, amino acids 2122-2380...
casein kinase 2, alpha 1 polypeptide, transcript variant 2, mRNA (cDNA clone MGC:15232 IMAGE:4121882), complete cds...
RABBIT ANTI D-TYROSINE CONJUGATE...
UV LAMP 254 NM 8 WATT, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: