Navigation Links
Weber State Scientists discover possible building blocks of ancient genetic systems
Date:11/9/2012

November 8, 2012 - Jackson Hole, Wyoming

Scientists believe that prior to the advent of DNA as the earth's primary genetic material, early forms of life used RNA to encode genetic instructions. What sort of genetic molecules did life rely on before RNA?

The answer may be AEG, a small molecule when linked into chains form a hypothetical backbone for Peptide Nucleic Acids, which have been hypothesized as the first genetic molecules. Synthetic AEG has been studied by the pharmaceutical industry as a possible genesilencer to stop or slow certain genetic diseases. The only problem with the theory is that up to now, AEG has been unknown from nature.

A team of scientists from the USA and Sweden announced that they have discovered AEG within cyanobacteria which are believed to be some of the most primitive organisms on earth. Cyanobacteria sometimes appear as mats or scums on the surface of reservoirs and lakes during hot summer months. Their tolerance for extreme habitats is remarkable, ranging from the hot springs of Yellowstone to the tundra of the Arctic.

"Our discovery of AEG in cyanobacteria was unexpected," explains Dr. Paul Alan Cox, coauthor on the paper that appeared today in the journal PLOS ONE. The American team, is based at the Institute for Ethnomedicine in Jackson Hole, and serve as adjunct faculty at Weber State University in Ogden, Utah.

"While we were writing our manuscript," Cox says, "we learned that our colleagues at the Stockholm University Department of Analytical Chemistry had made a similar discovery, so we asked them to join us on the paper."

To determine how widespread AEG production is among cyanobacteria, the scientists analyzed pristine cyanobacterial cultures from the Pasteur Culture Collection of Paris, France. They also collected samples of cyanobacteria from Guam, Japan, Qatar, as well as in the Gobi desert of Mongolia, the latter sample being collected by famed Wyoming naturalist Derek Craighead. All were found to produce AEG.

Professor Leopold Ilag and his student Liying Jiang at Stockholm University's Department of Analytical Chemistry analyzed the same samples and came up with identical results: cyanobacteria produce AEG. While the analysis is certain, its significance for studies of the earliest forms of life on earth remains unclear. Does the production of AEG by cyanobacteria represent an echo of the earliest life on earth?

"We just don't have enough data yet to draw that sort of conclusion," reports Cox. "However the pharmaceutical industry has been exploring synthetic AEG polymers for potential use in gene silencing, so I suspect we have much more to learn."


'/>"/>

Contact: Paul Alan Cox
paul@ethnomedicine.org
801-375-6214
Weber State University
Source:Eurekalert

Related biology news :

1. Compound in grapes, red wine could be key to fighting prostate cancer
2. High-strength material advancements at Wayne State University may lead to new, life-saving steel
3. Iowa State, Ames Lab researchers find 3 unique cell-to-cell bonds
4. New book on physics principles by Wayne State professor explains life as we know it
5. Sam Houston state developing lab test for bath salts
6. New study confirms erroneous link between XMRV and prostate cancer-contamination was the cause
7. Wayne State receives $2.8 million grant from US Administration for Children and Families
8. Smart growth strategies curb car use, greenhouse gas emissions, SF State study suggests
9. State stem cell research funding agency awards $37.3 million to aid UC Irvine efforts
10. SF State biologists tag zombees to track their flight
11. Epigenetic causes of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: