Navigation Links
Webcam technology used to measure medications' effects on the heart
Date:5/3/2011

Boston, MA A common component in webcams may help drug makers and prescribers address a common side-effect of drugs called cardiotoxicity, an unhealthy change in the way the heart beats. Researchers at Brigham and Women's Hospital (BWH) have used the basic webcam technology to create a tool to look at the effects of medications in real time on heart cells, called cardiomyocytes. These findings were published in the journal, Lab on a Chip on April 11, 2011.

Researchers developed a cost-effective, portable cell-based biosensor for real time cardiotoxicity detection using an image sensor from a webcam. They took cardiomyocytes, derived from mouse stem cells, and introduced the cells to different drugs. Using the biosensor, the researchers were able to monitor the beating rate of the cardiomyocytes in real time and detect any drug-induced changes in the beating rates.

The technology provides a simple approach to perform evaluative studies of different drugs effects on cardiac cells. Cardiotoxicity is a significant problem in drug development, with more than 30 percent of drugs withdrawn from the market between 1996 to 2006 related to cardiac dysfunction. "Assessing the toxic effects of new drugs during the early phases of drug development can accelerate the drug discovery process, resulting in significant cost and time savings, and leading to faster treatment discovery," said Ali Khademhosseini, PhD, of the Center for Biomedical Engineering at the Department of Medicine at BWH.

"This technology could also play a role in personalized medicine," said Sang Bok Kim, PhD, a Research Fellow in the Renal Division at BWH. "By first extracting somatic cells from patients which can be reprogrammed to stem cells called induced pluripotent stem (iPS) cells. Then these iPS cells can be differentiated into cardiac cells to be studied, the biosensor can monitor the cardiac cells as they're introduced to a medication, providing a glimpse at how the drugs may affect the individual's heart, and thus shaping the treatment plan for that person."

Monitoring cardiac cells in the past required using expensive equipment that had a limited measurement area. This low cost (less than $10) biosensor is compatible with conventional equipment but will enable reliable, yet faster and more cost-effective studies.

"Our next goal is to combine our detection sensor with our microwell arrays and perform screening studies of thousands of drugs to cardiac cells simultaneously in a fast and reliable manner," said Dr. Khademhosseini.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related biology news :

1. Webcam from Space: Envisat observing Wilkins Ice Shelf
2. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
3. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
4. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
5. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. So-called sandfish could help materials handling and process technology specialists
8. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
9. Human Microbiome Project awards funds for technology development, data analysis and ethical research
10. Europe rallies behind nanotechnology to wean world from fossil fuels
11. Nanotechnology boosts war on superbugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)...  RSA Conference -- RSA, a Dell Technologies business, ... enhance fraud detection and investigation across digital environments ... & Risk Intelligence Suite. The new platform is ... from internal and external sources as well as ... from targeted cybercrime attacks. "Fraudsters are ...
(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/8/2017)... Feb. 7, 2017 Report Highlights ... 2021 from $8.3 billion in 2016 at a compound ... 2021. Report Includes - An overview of the ... trends, with data from 2015 and 2016, and projections ... Segmentation of the market on the basis of product ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... IPSWICH, Mass. , Feb. 17, 2017 /PRNewswire/ ... a small tumor had a mutation-conferring resistance to ... treatment. Recently, genomics research has focused on finding ... — or even from circulating tumor DNA in ... identify new oncology therapeutics. Unfortunately, however, ...
(Date:2/16/2017)... ... February 16, 2017 , ... EIT Digital has launched work ... agricultural industry. Pilot studies are about to get under way for the framework, which ... 5G innovations. The concept is expected to be transferred eventually to other industries that ...
(Date:2/16/2017)... and GREENWICH, Conn. , ... investment firm focused on venture growth investments in ... of Josh Richardson , M.D. to Managing ... in biotechnology companies.  He is a board observer ... roles in Longitude,s investments in Aimmune Therapeutics, Akebia ...
(Date:2/16/2017)... Research and Markets has announced the addition ... to their offering. ... The study scope includes ... chassis organisms, synthetic cells, production systems), enabling technologies (DNA ... specialty media) and enabled technologies (biofuels, chemicals, pharmaceuticals, agriculture) ...
Breaking Biology Technology: