Navigation Links
Webcam technology used to measure medications' effects on the heart
Date:5/3/2011

Boston, MA A common component in webcams may help drug makers and prescribers address a common side-effect of drugs called cardiotoxicity, an unhealthy change in the way the heart beats. Researchers at Brigham and Women's Hospital (BWH) have used the basic webcam technology to create a tool to look at the effects of medications in real time on heart cells, called cardiomyocytes. These findings were published in the journal, Lab on a Chip on April 11, 2011.

Researchers developed a cost-effective, portable cell-based biosensor for real time cardiotoxicity detection using an image sensor from a webcam. They took cardiomyocytes, derived from mouse stem cells, and introduced the cells to different drugs. Using the biosensor, the researchers were able to monitor the beating rate of the cardiomyocytes in real time and detect any drug-induced changes in the beating rates.

The technology provides a simple approach to perform evaluative studies of different drugs effects on cardiac cells. Cardiotoxicity is a significant problem in drug development, with more than 30 percent of drugs withdrawn from the market between 1996 to 2006 related to cardiac dysfunction. "Assessing the toxic effects of new drugs during the early phases of drug development can accelerate the drug discovery process, resulting in significant cost and time savings, and leading to faster treatment discovery," said Ali Khademhosseini, PhD, of the Center for Biomedical Engineering at the Department of Medicine at BWH.

"This technology could also play a role in personalized medicine," said Sang Bok Kim, PhD, a Research Fellow in the Renal Division at BWH. "By first extracting somatic cells from patients which can be reprogrammed to stem cells called induced pluripotent stem (iPS) cells. Then these iPS cells can be differentiated into cardiac cells to be studied, the biosensor can monitor the cardiac cells as they're introduced to a medication, providing a glimpse at how the drugs may affect the individual's heart, and thus shaping the treatment plan for that person."

Monitoring cardiac cells in the past required using expensive equipment that had a limited measurement area. This low cost (less than $10) biosensor is compatible with conventional equipment but will enable reliable, yet faster and more cost-effective studies.

"Our next goal is to combine our detection sensor with our microwell arrays and perform screening studies of thousands of drugs to cardiac cells simultaneously in a fast and reliable manner," said Dr. Khademhosseini.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related biology news :

1. Webcam from Space: Envisat observing Wilkins Ice Shelf
2. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
3. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
4. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
5. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. So-called sandfish could help materials handling and process technology specialists
8. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
9. Human Microbiome Project awards funds for technology development, data analysis and ethical research
10. Europe rallies behind nanotechnology to wean world from fossil fuels
11. Nanotechnology boosts war on superbugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016   Parabon NanoLabs ... the U.S. Army Research Office and the Defense ... and sensitivity of the company,s Snapshot Kinship ... Mission and, more generally, defense-related DNA forensics.  Although ... capabilities (predicting appearance and ancestry from DNA evidence), ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
(Date:2/1/2016)...  Wocket® smart wallet ( www.wocketwallet.com ) announces the launch of a ... . Las Vegas , where Joey appeared at ... Las Vegas , where Joey appeared at the Wocket booth ... ad was filmed at the Consumer Electronics Show (CES2016) in ... meet and greet fans. --> --> ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... ... February 03, 2016 , ... Data ... new solutions focused on social housing of small animal models in research studies. ... data.¹, ² , DSI’s HD-S11 implant has evolved to allow researchers to simultaneously ...
(Date:2/3/2016)... ... ... Big games come and go, but only one will showcase the bravery ... nationally recognized brain diagnostics and technology company, will join NFL alumni and celebrities as ... Flag Football Game on February 6, 2016. , The event, scheduled to kick ...
(Date:2/2/2016)... , Feb. 2, 2016 INTRODUCTION ... of commensal, symbiotic and pathogenic microorganisms that reside ... body. The human microbiome is involved in various ... life. Majority of the microorganisms benefit humans by ... not possess. These include metabolism of complex carbohydrates, ...
(Date:2/2/2016)... and AARHUS, Denmark , ... and researchers gain access to QIAGEN,s enhanced solutions for ... ; Frankfurt Prime Standard: QIA) today announced new partnerships ... its market leading bioinformatics solutions for microbiome, metagenomics and ... Standard: QIA) today announced new partnerships to enhance the ...
Breaking Biology Technology: