Navigation Links
Webcam technology used to measure medications' effects on the heart
Date:5/3/2011

Boston, MA A common component in webcams may help drug makers and prescribers address a common side-effect of drugs called cardiotoxicity, an unhealthy change in the way the heart beats. Researchers at Brigham and Women's Hospital (BWH) have used the basic webcam technology to create a tool to look at the effects of medications in real time on heart cells, called cardiomyocytes. These findings were published in the journal, Lab on a Chip on April 11, 2011.

Researchers developed a cost-effective, portable cell-based biosensor for real time cardiotoxicity detection using an image sensor from a webcam. They took cardiomyocytes, derived from mouse stem cells, and introduced the cells to different drugs. Using the biosensor, the researchers were able to monitor the beating rate of the cardiomyocytes in real time and detect any drug-induced changes in the beating rates.

The technology provides a simple approach to perform evaluative studies of different drugs effects on cardiac cells. Cardiotoxicity is a significant problem in drug development, with more than 30 percent of drugs withdrawn from the market between 1996 to 2006 related to cardiac dysfunction. "Assessing the toxic effects of new drugs during the early phases of drug development can accelerate the drug discovery process, resulting in significant cost and time savings, and leading to faster treatment discovery," said Ali Khademhosseini, PhD, of the Center for Biomedical Engineering at the Department of Medicine at BWH.

"This technology could also play a role in personalized medicine," said Sang Bok Kim, PhD, a Research Fellow in the Renal Division at BWH. "By first extracting somatic cells from patients which can be reprogrammed to stem cells called induced pluripotent stem (iPS) cells. Then these iPS cells can be differentiated into cardiac cells to be studied, the biosensor can monitor the cardiac cells as they're introduced to a medication, providing a glimpse at how the drugs may affect the individual's heart, and thus shaping the treatment plan for that person."

Monitoring cardiac cells in the past required using expensive equipment that had a limited measurement area. This low cost (less than $10) biosensor is compatible with conventional equipment but will enable reliable, yet faster and more cost-effective studies.

"Our next goal is to combine our detection sensor with our microwell arrays and perform screening studies of thousands of drugs to cardiac cells simultaneously in a fast and reliable manner," said Dr. Khademhosseini.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Related biology news :

1. Webcam from Space: Envisat observing Wilkins Ice Shelf
2. BIO-key(R) to Showcase Biometric Security Applications at 2008 Biometric Technology Expo
3. Stantum Offering Demo, Evaluation & Development Board Based on Its Patented Resistive Multi-Touch Technology
4. Neurotechnology Releases SentiSight 2.0 SDK Universal Object Recognition Technology
5. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
6. Breakthrough optical technology to assess colon cancer risk, accuracy
7. So-called sandfish could help materials handling and process technology specialists
8. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
9. Human Microbiome Project awards funds for technology development, data analysis and ethical research
10. Europe rallies behind nanotechnology to wean world from fossil fuels
11. Nanotechnology boosts war on superbugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... , Mar 24, 2017 Research and ... Access System Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 15.1% over the next ... This industry report analyzes the market estimates and forecasts for all ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Recently recognized by CIO Magazine ... the migration of its flagship cloud-based product Planet Life Cycle – a robust ... management system that merges strategic and financial planning with execution. The solution is ...
(Date:7/17/2017)... ... July 17, 2017 , ... Neurodevelopmental disorders (NDDs) are ... overlapping clinical features. The advancement of targeted next-generation sequencing (NGS) has been instrumental ... testing. , However, designing a custom panel for disease research requires hours ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Extreme Environment Shakers ... applications that require CO2 and humidity for optimal cell growth such as cell ...
(Date:7/14/2017)... Belgium/ Denville, USA/ Martinsried, Germany (PRWEB) , ... ... ... announced a newly developed standardized solution for sample preparation of proteins to clean ... and the Diagenode Bioruptor® sonication system. , The PreOmics iST Kit is ...
Breaking Biology Technology: