Navigation Links
We are not only eating 'materials', we are also eating 'information'
Date:9/19/2011

In a new study, Chen-Yu Zhang's group at Nanjing university present a rather striking finding that plant miRNAs could make into the host blood and tissues via the route of food-intake. Moreover, once inside the host, they can elicit functions by regulating host "target" genes and thus regulate host physiology.

MicroRNAs are a class of 19-24 nucleotide non-coding RNAs that do not code for proteins. MicroRNAs bind to target messenger RNAs to inhibit protein translation. In previous studies, the same group has demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for disease and act as signaling molecules in intercellular communication.

Here, they report the surprising finding that exogenous plant miRNAs are present in the sera and tissues of various animals and that these exogenous plant miRNAs are primarily acquired orally, through food intake. MIR168a is abundant in rice and is one of the most highly enriched exogenous plant miRNAs in the sera of Chinese subjects. Functional studies in vitro and in vivo demonstrated that MIR168a could bind to the human/mouse low density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma. These findings demonstrate that exogenous plant miRNAs in food can regulate the expression of target genes in and thus physiology of mammals.

The finding is obviously very thought-provoking; for instance, it would indicate that in addition to eating "materials" (in the form of carbohydrates, proteins, etc), you are also eating "information" (as different miRNAs from distinct food sources could well bear different consequences on the regulation of host physiology once taken by the host due to potential regulation of different target genes as determined by the "information" contained within the miRNA sequence), t
'/>"/>

Contact: Chen-Yu Zhang
cyzhang@nju.edu.cn
86-258-368-6234
Nanjing University School of Life Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study in underwater laboratory may help manage seaweed-eating fish that protect coral
2. Gladstone scientist finds new target for treating symptoms of Parkinsons disease
3. Seizing the opportunity: treating epilepsy in cats
4. Child-care facilities can do more to promote healthy eating and physical activity among preschoolers
5. Government-led efforts targeting eating habits of children needed to curb worldwide obesity epidemic
6. SUNY Downstate researchers identify possible new targets for treating pain in women
7. No bones about it: Eating dried plums helps prevent fractures and osteoporosis
8. Researchers demonstrate green tea is effective in treating genetic disorder and types of tumors
9. Children eating more, and more frequently outside the home
10. Study shows answers for treating obesity-related diseases may reside in fat tissue
11. Adolescents dieting and disordered eating behaviors continue into young adulthood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... DUBLIN , June 24, 2015 ... the addition of the "Latin America Biomedical Sensors ... to their offering. The Latin America Biomedical ... at a CAGR of 2.04% over the period 2014-2020 ... that are adaptable to the genetic formulation of each ...
(Date:6/25/2015)... , June 25, 2015  Imagine a tool specifically ... a healthier, happier life. That,s exactly what USANA,s ... do. The cutting-edge, portable health program provides a personalized ... to help improve your lifestyle and nutrition. ... and gala Wednesday night, USANA,s THA was honored with ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... tissue during surgical operations has the potential to produce ... conventional sutures and stapling in intestinal surgery, scientists are ... solder, or sealing material, appears in the journal ... explain that laser tissue welding (LTW) is a "stitch-free" ...
... provider of scientific, technical and medical information products and ... by the European Menopause and Andropause Society (EMAS) in ... peri and postmenopausal women with summary recommendations. The ... of the endometrium and premalignant endometrial hyperplasia. Assessment of ...
, This press release is available in spanish . Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing, ,...
Cached Biology News:
(Date:7/3/2015)... ... 2015 , ... The global failure analysis market is expected to reach $7,147.0 ... market is expected to grow at the highest CAGR of 8.46%; its growth is ... research labs and academic institutions for root cause analysis of failure. The market based ...
(Date:7/3/2015)... YORK , July 3, 2015  Pomerantz LLP ... against Puma Biotechnology, Inc. ("Puma" or the "Company")(NYSE: ... action, filed in United States District Court, Central District ... 15-cv-00865, is on behalf of a class consisting of ... July 23, 2014 and May 13, 2015 inclusive (the ...
(Date:7/2/2015)... College of DuPage students Sam Liesman ... real-world experiences while serving biophysics internships at the prestigious ... students will be working as a part of IIT ... IIT. The internship came about from a discussion between ... Kathy Finan , Biology; and Dr. Wereszczynski regarding ...
(Date:7/2/2015)... ... ... Sleepless nights will become obsolete as Luzi , a sophisticated smart ... June 23. Sound sleepers and the sleep deprived both will love Luzi for its ... integration of the Bluetooth speaker, alarm clock and ability to charge various devices, including ...
Breaking Biology Technology:Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4COD Students Participate in Prestigious Summer Internships 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3
... Madison, Wis. - The parent company of a ... the voluntary nature of the product following the signing ... from requiring them to be implanted. , ,Scott Silverman, ... VeriChip Corp., said the company's practices are consistent with ...
... Claire, Wis. - Tundra Semiconductor Corp. , ... communications and computing markets, has announced the acquisition of ... design company based in Eau Claire, for $14 million. ... Claire as a division of Tundra Semiconductor Corp. The ...
... M. Price about his book "The Eye For Innovation: ... includes his comments about business, strategy, innovation and "the ... he writes, "business strategy is about people." , ... led Control Data Corp. (CDC) from a hardware-only firm ...
Cached Biology Technology:Company defends RFID implant product 2Canadian firm acquires Silicon Logic 2New book from former CDC CEO walks readers through innovation 2New book from former CDC CEO walks readers through innovation 3New book from former CDC CEO walks readers through innovation 4
... PBL's bioassays for interferons are cytopathic effect ... assays. Sample types include; tissue culture supernatents; ... In these assays, one unit is defined as ... reduce the cytopathic effect of viral infection by ...
supplied with 10x reaction buffer...
... cytopathic effect inhibition assays, also known as CPE ... culture supernatents; serum from PK studies and delivery ... defined as the quantity of interferon required per ... infection by 50%. All standards used ...
... BioPrime Plus Array CGH Genomic Labeling Systems ... reproducible labeling of genomic DNA samples for ... both indirect and direct labeling formats, the ... provide a flexible solution to your genomic ...
Biology Products: