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Wayne State to study the role of vitamin D in African-Americans with high blood pressure
Date:6/2/2011

e in blacks but whether supplementation can reduce this risk is not known. It is thought that vitamin D deficiency may accelerate ventricular changes that occur with high blood pressure, thus serving as a potential point of intervention.

The study will include Detroit Receiving Hospital emergency department patients between the ages of 30 and 74, who come to the hospital with poorly controlled chronic hypertension but no prior history of secondary cardiovascular disease. Levy said 267 patients who agree to participate in the study will be screened, with the anticipation that 75 percent will have vitamin D deficiency. Those with vitamin D deficiency will then undergo cardiac magnetic resonance imaging to screen for increased left ventricular mass. Based on prior work funded by the Robert Wood Johnson Foundation Physician Faculty Scholars Program, Levy anticipates that 60 percent of those evaluated by MRI will have left ventricular hypertrophy resulting in a final sample of 120 patients. These study enrollees will be randomized to receive blood pressure control with additional placebo or vitamin D supplements for an entire year.

Levy said patients enrolled in the study will receive 50,000 international units (IU) of vitamin D3 every other week, an amount consistent with current therapeutic recommendations. The supplement will be provided in a liquid gel capsule. Most people who take vitamin D purchased over the counter ingest 1,000 IU daily.

Levy expects to find that individuals who receive vitamin D therapy will experience a regression in left ventricular mass beginning 16 weeks after they start taking the supplements. That regression should continue and increase in magnitude over the course of a year. Myocardial fibrosis, which comprises much of the increase of left ventricle mass in those with hypertension, should decrease. Other expected outcomes include improved vascular function with a decrease in central and possibly peripheral blood
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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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