Navigation Links
Wayne State study finds soybean compounds enhances effects of cancer radiotherapy
Date:12/19/2011

Detroit - A Wayne State University researcher has shown that compounds found in soybeans can make radiation treatment of lung cancer tumors more effective while helping to preserve normal tissue.

A team led by Gilda Hillman, Ph.D., professor of radiation oncology at Wayne State University's School of Medicine and the Barbara Ann Karmanos Cancer Institute, had shown previously that soy isoflavones, a natural, nontoxic component of soybeans, increase the ability of radiation to kill cancer cells in prostate tumors by blocking DNA repair mechanisms and molecular survival pathways, which are turned on by the cancer cells to survive the damage radiation causes.

At the same time, isoflavones act to reduce damage caused by radiation to surrounding cells of normal, noncancerous tissue. This was shown in a clinical trial conducted at WSU and Karmanos for prostate cancer patients treated with radiotherapy and soy tablets.

In results published in the journal Nutrition and Cancer in 2010, those patients experienced reduced radiation toxicity to surrounding organs; fewer problems with incontinence and diarrhea; and better sexual organ function. Hillman's preclinical studies in the prostate tumor model led to the design of that clinical trial.

Soy isoflavones can make cancer cells more vulnerable to ionizing radiation by inhibiting survival pathways that are activated by radiation in cancer cells but not in normal cells. In normal tissues, soy isoflavones also can act as antioxidants, protecting those tissues from radiation-induced toxicity.

During the past year, Hillman's team achieved similar results in non-small cell lung cancer cells in vitro. She recently received a two-year, $347,000 grant from the National Cancer Institute, part of the National Institutes of Health, to investigate whether those results also proved true for non-small cell lung tumors in mice, and has found that they do. Her findings, which she called
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genomatix gives a hand in the analysis of Wayne States sequencing projects
2. NextCAT Inc. secures $250,000 to commercialize biodiesel technology developed at Wayne State
3. NextCAT secures license agreement for advanced biofuel technology from Wayne State
4. Soy increases effectiveness of radiation at killing lung cancer, Wayne State study shows
5. Wayne State University chosen as Michigans sole participant in EcoCAR 2
6. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
7. Wayne State researcher discovers antibiotic useful for localized treatment of bone wear
8. Wayne State start-up company NextCAT awarded nearly $500,000 from NSF for Phase II SBIR
9. EPA grants help Wayne State researchers stave off Great Lakes environmental invaders
10. Wayne State announces license agreement for breakthrough approaches to vision restoration
11. Better CMT outcome measurement is Wayne State University physicians goal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... 2015 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends and ... recognition is forecast to reach US$ 2,671.8 Mn by ... surveillance systems by civil and government agencies. This is ... terrorist activities across the globe that would elevate the ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:8/3/2015)... SAN JOSE, Calif. , Aug. 3, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that members ... investment community at the Pacific Crest Global Technology Leadership ... Mountain Time. The conference will be held at the ... The presentation may include forward-looking information. ...
Breaking Biology News(10 mins):Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... season coming up soon, egg consumption is expected to rise temporarily. ... of eggs they can? "Parasites such as fowl mites that ... more," says Bradley A. Mullens , a professor of ... to boost egg production is to rid the hens of these ...
... bacteria in the genus Rickettsia spread through a population of ... pest of global importance. Infected insects lay more eggs, develop ... to their uninfected peers. The discoveries were made by ... in the April 8 issue of the journal Science ...
... known to favor the evolution of a variety of traits, ... changes in metabolism and feeding behavior. Now researchers reporting online ... Press publication, have added sleeplessness to that list. "Cave-adapted ... Borowsky of New York University. "In some ways, their sleep ...
Cached Biology News:UC Riverside entomologists propose pesticide-free method to increase egg production 2Instant evolution in whiteflies: Just add bacteria 2Instant evolution in whiteflies: Just add bacteria 3Instant evolution in whiteflies: Just add bacteria 4Through evolution, cavefish have lost sleep 2
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... ended June 30, 2015. Biorem,s complete second quarter financial statements and ... FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended , Six -months ... , 2015 , 2014 Revenue , 4,709 ... 4,433 Gross profit , 1,656 , 56 ...
(Date:8/27/2015)... , Aug. 27, 2015 In response ... FedEx, UPS and The US Postal Service to ... classified as ,select agents, by the CDC, Marken ... handling these sensitive shipments. Marken uses ... regulations, trained and certified personnel to ensure the ...
(Date:8/26/2015)... ... August 26, 2015 , ... ... its investment in the development and manufacture of highly valued cardiac markers used ... scientific team's extensive expertise with protein chemistry has led to the development and ...
(Date:8/26/2015)... HONG KONG , Aug. 26, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... Holdings Limited ("MO2"), an entity wholly owned by Mr. ... the Company, has acquired the outstanding shares (the "Shares") ...
Breaking Biology Technology:BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3
... Dynamic, thorough, and robustly qualified are a few ... Consultant, Philippe Vitat, who brings with him expertise and an ... as a certified medical writer and editor since 2001 and ... medical education by the International Biographical Center in Cambridge, ...
... ... The Chinese Biopharmaceutical Association-USA (CBA) announced today that it ... Maryland, US. ,The event will highlight current breakthroughs, new ... develop a platform for communication and collaboration among biopharmaceutical companies, ...
... an interview with a researcher, please contact the Communications and ... tip. For more information on ORNL and its research and ... If you have a general media-related question or comment, you ... MILITARY - Intelligent intelligence . . . ...
Cached Biology Technology:Highly Regarded Medical Writer Joins Avant Healthcare Marketing Team 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 2Chinese Biopharmaceutical Association Holds 15th Annual Conference in Rockville, MD, June 12 - 13 3Story tips from the Department of Energy's Oak Ridge National Laboratory May 2010 2Story tips from the Department of Energy's Oak Ridge National Laboratory May 2010 3
...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
...
... offers a dedicated system for SFC and ... series of HPLC instrumentation. JASCO has recently ... capability of the system: ,- The PU-1580-CO2 ... extraction procedures using carbon dioxide as the ...
Biology Products: