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Wayne State researchers working to improve genetic analysis, disorder detection
Date:8/3/2012

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Researchers will isolate trophoblasts using immunomagnetic nanotechnology, taking advantage of unique proteins on the surface of fetal cells. Highly sensitive genetic tools capable of analyzing single cells will verify the fetal origin of captured cells before their DNA is analyzed for chromosome number.

Armant said that tests based on fetal cells obtained from the cervix eventually could alert doctors to things like ectopic pregnancy, miscarriage, preterm labor, poor fetal growth, preeclampsia, fetal Rh incompatibility and chromosome number disorders, like Down syndrome. It also could help detect inherited genetic diseases, such as muscular dystrophy, sickle cell anemia and hemophilia.

The goal is to determine if placental cells obtained from the cervix accurately represent the chromosomal status of the fetus.

"Development of this diagnostic platform for the detection of chromosome number disorders could establish an innovative approach for prenatal genetic testing that would provide immense opportunities for improving the health of mothers and their babies," Armant said.


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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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