Navigation Links
Wayne State researcher discovers antibiotic useful for localized treatment of bone wear
Date:8/9/2011

DETROIT Total joint replacement surgeries can help relieve joint pain common in people with conditions like osteoarthritis. But sometimes, the debris from prosthetic joints leads to aseptic loosening, or disintegration of surrounding bones. In 2009, a Wayne State University researcher determined that the anti-inflammatory antibiotic erythromycin can prevent and treat such disintegration. There was one caveat, however: there are side effects associated with long-term usage of erythromycin.

But Weiping Ren, M.D., Ph.D., associate professor of biomedical engineering in WSU's College of Engineering, has found a solution. Erythromycin can be administered directly at the site of bone breakdown, rather than orally, so the whole body is not affected. The details of Ren's study are published in the August 2011 issue of Clinical Orthopaedics and Related Research.

"Although oral erythromycin reportedly inhibits inflammation in patients with aseptic loosening, long-term systematic (oral) erythromycin treatment is not recommended," said Ren.

Used primarily for its antimicrobial properties, erythromycin is used to treat conditions like respiratory tract infections and whooping cough, both caused by harmful bacteria. In addition to fighting bacteria, erythromycin reduces inflammation, making it a successful treatment for aseptic loosening.

"But long-term systemic use of erythromycin raises concerns about various side effects, including bacterial resistance, liver damage and gastrointestinal discomfort," said Ren. "We hypothesized that it may be advantageous to restrict erythromycin delivery to the inflammatory tissue around the implant to avoid these side effects."

To test his idea, Ren implanted metal pins coated with erythromycin in the inflamed tissue surrounding the prosthetic joint. He measured bone growth and implant stability, both indicators of how well the prosthesis integrates with the bone, and analyzed micros
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
734-748-4207
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genomatix gives a hand in the analysis of Wayne States sequencing projects
2. NextCAT Inc. secures $250,000 to commercialize biodiesel technology developed at Wayne State
3. NextCAT secures license agreement for advanced biofuel technology from Wayne State
4. Soy increases effectiveness of radiation at killing lung cancer, Wayne State study shows
5. Wayne State University chosen as Michigans sole participant in EcoCAR 2
6. Wayne State to study the role of vitamin D in African-Americans with high blood pressure
7. NC State researchers get to root of parasite genome
8. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
9. NC State takes lead in crime scene investigation training
10. Penn State receives new NASA astrobiology grant
11. Penn State researcher wins Entomological Society of America award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... of captive black rhino reproduction in Europe highlights ... breeding programmes. , Researchers from Chester Zoo, The ... carried out a six-year study which encompassed 90% ... Katie Edwards led the research as part of ... says: "Although some black rhinoceros breed well in ...
(Date:8/22/2014)... and the bees. But that old expression leaves ... fertilization process for flowering plants is particularly complex ... female reproductive cells. New research from an international ... including Carnegie,s Wolf Frommer, David Ehrhardt, and Guido ... that guides flowering plant fertilization. It is published ...
(Date:8/21/2014)... -- Nxt-ID, Inc. (OTCQB: NXTD), a biometric authentication company ... that its shares of common stock and the warrants ... proposed underwritten public offering of common stock and warrants ... Market, subject to closing of its proposed underwritten public ... trade under the symbol "NXTD" and "NXTDW," respectively. ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Calcium and reproduction go together 2Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... forests of Thailand have given conservationists confirmation that anti-poaching ... the Wildlife Conservation Society. The footagetaken by ... Complex over the last yearhas revealed a cornucopia of ... gaurs, sun bears, and many other species. The clips ...
... Researchers with the U.S. Department of Energy (DOE),s ... of time-lapse live imaging and mathematical modeling of a ... to suggest that for low dose levels of ionizing ... dose. This contradicts the standard model for predicting biological ...
... human skulls have shown that changes to the skull ... events may have actually precipitated each other. Researchers ... skulls from the Austrian town of Hallstatt and found ... variation in one part of the skull is linked ...
Cached Biology News:Candid video clips from Thailand show anti-poaching efforts saving wildlife 2New take on impacts of low dose radiation 2New take on impacts of low dose radiation 3New take on impacts of low dose radiation 4Human skull study causes evolutionary headache 2
(Date:8/21/2014)... Texas (PRWEB) August 21, 2014 ... Seaweed Fertilizer Industryā€¯ is a professional and ... market. The report provides basic Seaweed Fertilizer ... and industry chain structure as well as ... market analysis, including domestic market as well ...
(Date:8/21/2014)... , Aug. 21, 2014 Telomere Biosciences, ... their Nutraceutical "TELO-20 for Dogs" with Telomerase ... supplement in the world for dogs. Telomeres are ... chromosome in the body. A wealth of ground-breaking ... in Telomere Science and Aging, including Nobel laureates, ...
(Date:8/21/2014)... 21, 2014 Mathematic studies at the Program ... and funded by the Jeffrey Epstein VI Foundation , ... be visually identified for elimination. These aggressive cells are the ... shows a topological map of what to look for when ... for while tumor cells can be extracted from biopsy, it,s ...
(Date:8/21/2014)... 21, 2014  Four-dimensional (4-D) printing develops materials ... external stimuli such as changes in temperature. This ... effect in multiple industries.  In the near future, ... printing objects ranging from human organs to parts ... Logo - http://photos.prnewswire.com/prnh/20140820/138289 ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
... in Latin,America, WASHINGTON, June 12 The ... San Francisco (UCSF) announced,today that 10 promising biomedical ... in the Biomedical Sciences. Funded by Pew through ... offers talented,young Latin American scientists $60,000 for a ...
... today the,results of tests utilizing its Ygiene(TM) formulation ... is designed to be used by the,military and ... "The Ygiene(TM) formulation killed all anthrax spores exposed ... said Dr. Philip Tierno, the,Principal Investigator on the ...
... Company Begins Process to Restore Shareholder Value Following NEBIDO(R) ... ... Indevus,Pharmaceuticals, Inc. (Nasdaq: IDEV ) today announced that Glenn L. Cooper,MD, ... the Company through the challenges,it faces as a result of the recent ...
Cached Biology Technology:Ten Latin American Scientists Named 2008 Pew Fellows in the Biomedical Sciences 2BioNeutral Announces a BREAKTHROUGH in the Fight Against Bioterrorism 2Indevus Announces Management Changes 2Indevus Announces Management Changes 3Indevus Announces Management Changes 4
Request Info...
Recommend to use at up to 5000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
... Avidin is chromatographically purified from egg white. The ... 15.5.The product is in 10 mM phosphate-buffered ... serum albumin, 0.05% sodium azide and 50% glycerol. ... The conjugate is purified by molecular sieving ...
... The Zero Blunt TOPO ... Sequencing is designed for ... of blunt-end PCR products. ... 5-minute TOPO Cloning and ...
Biology Products: