Navigation Links
Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
Date:12/20/2013

ted), 3, 7, 10, 14, and 21 days while still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.

Specifically, "bad" cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of "good" cholesterol could be seen as early as Day Three for that same group. By Day 21, "good" cholesterol levels increased by 28% and "bad" cholesterol levels decreased by 30%.

Additionally, metabolomics analysis was conducted to analyze the concentration of certain metabolites (small molecules which are byproducts of normal metabolic functions) in the blood. Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease.

Gene expression analysis was also conducted, to get a deeper insight into the increase in plasma HDL-c levels. Thus the expression levels (mRNA) of proteins involved in HDL-c metabolism were evaluated. By Day Ten, subjects showed a threefold increase in the gene expression of APO A1, a major protein associated with the production of HDL particles, the "good" cholesterol which increased sixfold by Day 21.

"To put this in perspective, the benefit of raising HDL can be explained by examining how these "good" cholesterol particles function: They play a key role in removing excess cholesterol from cell storage and transporting that cholesterol to the liver for excretion from the body," said Amy Steffek, Ph.D., HEPI Director of Research & Development. "They also have other properties that promote and protect cardiovascular health, and serve as an independent predictor of cardiovascular risk. To simplify, one can lower risk of cardiovascular disease by increasing
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
2. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
3. Wayne State receives grant to reduce emissions of toxins by power plants into Great Lakes
4. Wayne State receives NSF grant to develop plan for field-based water research center
5. Wayne State welcomes undergraduates from around the US for physics research experience
6. Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
7. Wayne State vision restoration technology receives Notice of Allowance for US patent app
8. Wayne State study shows airborne dust in urban areas impacts lead levels in children
9. Wayne State University researchers techniques enable more, faster testing of biological liquids
10. Cancer risk for African-American women with benign breast disease factors Wayne State finds
11. High-strength material advancements at Wayne State University may lead to new, life-saving steel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
(Date:8/27/2014)... health advocates, campaigns against trans-fats have largely succeeded ... taking aim at sugar for its potential contributions ... are still wrangling over the best way to ... an article in Chemical & Engineering News ... American Chemical Society. , In the article, Stephen ...
(Date:8/27/2014)... that piglets can be weaned later with no negative ... the study at the University,s Roseworthy campus, published in ... important finding for pig producers. It allows improvements in ... "Sows don,t usually start their oestrous cycles again during ... been weaned," says Ms Alice Weaver, PhD candidate with ...
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2
... Calif. ( http://www.ucr.edu ) A University of ... a group of researchers that have made important ... oscillator, which could serve as a timekeeping device ... assistant professor of mechanical engineering at UC Riverside,s ...
... Wistar Institute have developed a mathematical method for classifying ... brain cancer, through variations in the way these tumor ... predicting the subclasses of glioblastoma tumors with 92 ... physicians to accurately predict which forms of therapy would ...
... Are you active at your job? If you,re like most ... A team of researchers at the University of Iowa ... on movement. Yet the group found that police officers burn ... holding a baby or washing dishes. "We find that ...
Cached Biology News:Artificial cells and salad dressing 2Wistar scientists develop gene test to accurately classify brain tumors 2Wistar scientists develop gene test to accurately classify brain tumors 3Workers, get up and move 2Workers, get up and move 3
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Lactic Acid  (Biodegradable Polymer, Food & ... & Forecasts to 2019" report to their ... hydroxyl-carboxylic acid with an asymmetrical carbon atom. The ... biodegradable polymer, food and beverage, personal care product, ...
(Date:8/27/2014)... 27, 2014  A novel biomarker for rheumatoid ... better identify early-stage disease, when treatment can often ... a new study in The Journal of Rheumatology. ... DGX ) and other institutions found that ... conventional antibody-serum testing, including rheumatoid factor (RF) and ...
(Date:8/27/2014)... 27, 2014 Guggenheim Securities, the investment banking ... the hiring of veteran equity analyst Charles "Tony" Butler ... Butler will focus on the biotech/biopharma sector. ... of experience and a broad network of relationships in ... Director and Head of Equities at Guggenheim Securities. "His ...
(Date:8/27/2014)... Flagship Biosciences LLC, a leading provider of ... and medical device industries, has announced a laboratory and ... has consolidated its histology and tissue analysis operations from ... just north of Denver. The new addresses are: ... Suite 100, Westminster, CO 80021 , Tissue Image Analysis ...
Breaking Biology Technology:Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Flagship Biosciences Announces Relocation and Expansion 2
... Laboratories , a leading single source provider of contract ... of analytical testing and ... testing is the perfect complement to our portfolio ... of Microtest Laboratories ( www.microtestlabs.com ). "By ...
... Orexigen(R) Therapeutics, Inc. (Nasdaq: OREX ), a biopharmaceutical company focused ... at the following meetings:, BIO 2009 Business Forum, ... a.m. - 9:35 a.m. Eastern, Location: Georgia World Congress ... Senior Vice President, Medical Affairs and, ...
... Transgenomic Inc. (OTC Bulletin Board: TBIO) announces the following Webcast: , ... Conference Call, ... Where: http://www.transgenomic.com/events.asp?id=6 , ... at, ...
Cached Biology Technology:Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 2Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 3Reminder: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast 2
Agarose-LE, 500 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Request Info...
Limit of detection: <5 pg/ml...
Biology Products: