Navigation Links
Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
Date:12/20/2013

ted), 3, 7, 10, 14, and 21 days while still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.

Specifically, "bad" cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of "good" cholesterol could be seen as early as Day Three for that same group. By Day 21, "good" cholesterol levels increased by 28% and "bad" cholesterol levels decreased by 30%.

Additionally, metabolomics analysis was conducted to analyze the concentration of certain metabolites (small molecules which are byproducts of normal metabolic functions) in the blood. Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease.

Gene expression analysis was also conducted, to get a deeper insight into the increase in plasma HDL-c levels. Thus the expression levels (mRNA) of proteins involved in HDL-c metabolism were evaluated. By Day Ten, subjects showed a threefold increase in the gene expression of APO A1, a major protein associated with the production of HDL particles, the "good" cholesterol which increased sixfold by Day 21.

"To put this in perspective, the benefit of raising HDL can be explained by examining how these "good" cholesterol particles function: They play a key role in removing excess cholesterol from cell storage and transporting that cholesterol to the liver for excretion from the body," said Amy Steffek, Ph.D., HEPI Director of Research & Development. "They also have other properties that promote and protect cardiovascular health, and serve as an independent predictor of cardiovascular risk. To simplify, one can lower risk of cardiovascular disease by increasing
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Wayne State discovers potential treatment for skin and corneal wound healing in diabetics
2. Wayne State researchers discover specific inhibitor for rheumatoid arthritis treatment
3. Wayne State receives grant to reduce emissions of toxins by power plants into Great Lakes
4. Wayne State receives NSF grant to develop plan for field-based water research center
5. Wayne State welcomes undergraduates from around the US for physics research experience
6. Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
7. Wayne State vision restoration technology receives Notice of Allowance for US patent app
8. Wayne State study shows airborne dust in urban areas impacts lead levels in children
9. Wayne State University researchers techniques enable more, faster testing of biological liquids
10. Cancer risk for African-American women with benign breast disease factors Wayne State finds
11. High-strength material advancements at Wayne State University may lead to new, life-saving steel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
(Date:1/22/2015)... /PRNewswire/ - Today, FindBiometrics, the leading source of biometrics industry news, ... website design. "When we launched FindBiometrics 12 years ... O,Neill , founder and CEO of FindBiometrics. "Now it,s maturing ... the key players on a very broad scale.  We are ...
(Date:1/22/2015)... 2015  A man-made form of insulin delivered by nasal ... in adults with mild cognitive impairment and Alzheimer,s disease ... at Wake Forest Baptist Medical Center. The ... cognitive impairment (MCI) or mild to moderate Alzheimer,s dementia ...
(Date:1/22/2015)... , January 22, 2015 , ... year  The European Patent Office to present a video ... British nominations to be featured: Christofer Toumazou and ... former finalists and winners of the Award   Starting ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... and Zafer Iqbal, research professors at NJIT, were awarded ... arrays of nanoscale electrical probes. Their discovery may ... variation of electrical activity inside biological cells. ... technique that allows for an array of individual, vertically-oriented ...
... DUNES NATIONAL LAKESHORE, Ind. Native bees often small, ... stinging honeybees are quite discriminating about where they ... The study found that, overall, composition of a plant ... a bee community, which may seem counterintuitive at first, ...
... of California, Riverside have made a discovery in the ... drugs and explore novel strategies for treating seizures associated ... Americans. Neurons, the basic building blocks of the ... and chemical signaling. During epileptic seizures, which generally ...
Cached Biology News:Patent for arrays of nanoscale electrical probes awarded to NJIT today 2Picky pollinators: Native bees are selective about where they live and feed 2Picky pollinators: Native bees are selective about where they live and feed 3Picky pollinators: Native bees are selective about where they live and feed 4UC Riverside neuroscientists' discovery could bring relief to epilepsy sufferers 2
(Date:1/23/2015)... Biofertilizers stimulate microbial activities in soil. These microorganisms ... the activities in the soil or in the rhizosphere. ... stress on reducing environmental pollution and on reducing the ... segments the bio fertilizers market with analysis and forecasting ...
(Date:1/22/2015)...  Transwestern | RBJ today announces the firm brokered a long-term ... a leading biopharmaceutical company, at Two Ledgemont Center in ... Richards , president, and Brian Cohen , senior vice ... building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... RI (PRWEB) January 22, 2015 Protocol ... , The growing team of brand-neutral, independent consultants, Protocol ... Philip Rogers explained that over the years, his company ... , Moroso, Town of Plainfield, as well as others. ...
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2
... July 9 Abt Bio-Pharma Solutions, Inc.,(ABS), ... economic, and,strategic commercialization solutions, is pleased to ... and business strategy, has been promoted to,Executive ... succeeding Susan Windham-Bannister, who has been appointed,President ...
... Provides expertise in high-growth therapeutic areas to pharmaceutical and ... biotechnology companies ... the last year, BEVERLY HILLS, Calif., July 9 Worldwide Clinical,Trials, ... reached a milestone in establishing itself as a premier global,contract research organization ...
... July 9 Cepheid (Nasdaq:,CPHD) today announced ... on Healthcare Associated Infections, Fred Tenover, Ph.D., ... will serve as a liaison,with the Infection ... Infection (HAI) Consortium program., "The objective ...
Cached Biology Technology:Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 2Abt Bio-Pharma Solutions, Inc. Names Nandini Hadker as Executive Director, Succeeding Susan Windham-Bannister 3Worldwide Clinical Trials Emerges as Leading Global Contract Research Organization 2Worldwide Clinical Trials Emerges as Leading Global Contract Research Organization 3Noted Molecular Epidemiologist Joins Cepheid to Head Healthcare Associated Infection Consortium Program 2Noted Molecular Epidemiologist Joins Cepheid to Head Healthcare Associated Infection Consortium Program 3
Mouse monoclonal [SH-A1] to S100 alpha ( Abpromise for all tested applications). entrezGeneID: 6271 SwissProtID: P23297...
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXS6673E protein). [Source:Uniprot/SWISSPROT;Acc:Q14202] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: