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Wayne State University researcher's model will target causes of everyday MS symptoms
Date:2/14/2012

Detroit Annoying, frustrating symptoms like difficulty hearing or remembering things can complicate everyday living for multiple sclerosis (MS) patients, but most research to date has focused on the disease's less frequent but more debilitating consequences.

Recently, however, an increasing number of patients have expressed their desire for a better quality of life between relapses, as the body attacks its own central nervous system, which can cause blindness or the inability to use a limb.

"Everyone reacts more strongly to changes that are big rather than subtle changes that occur every day," said Alexander Gow, Ph.D., professor in Wayne State University's Center for Molecular Medicine and Genetics and School of Medicine's departments of pediatrics and neurology, who recently received a one-year, $114,000 grant from the U.S. Department of Defense to develop a new model system that focuses on the latter.

Approximately 400,000 Americans have MS, and every week about 200 people are diagnosed. Worldwide, it affects about 2.5 million people.

Over time, Gow said, MS patients can lose their ability to focus mentally, forget what they want to do or have difficulty following conversations. But because the causes of MS are still somewhat unclear, he believes part of the reason for the lack of attention to such symptoms may lie in clinicians' inability to offer solutions to patients.

Patients can become extremely depressed or frustrated at their inability to perform daily mental functions, which has led some to undergo drug treatments similar to those used to treat behavioral disorders. However, Gow said, such treatments may not be all that effective for many MS patients.

He believes the immune system attacks that damage or destroy white matter brain cells (oligodendrocytes) and cause the more catastrophic symptoms of MS also destroy cells in the brain's gray matter cells (neurons), where auditory, visual and cogniti
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Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

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