Navigation Links
Water-polluting anxiety drug reduces fish mortality
Date:8/7/2014

A drug that is commonly used to treat anxiety in humans and which regularly finds its way into surface waters through wastewater effluence has been shown to reduce mortality rates in fish.

The results, which have been published today, 8 August, in IOP Publishing's journal Environmental Research Letters, may have significant implications for existing standard ecotoxicological tests, which predominantly focus on harmful effects of water contaminants and ignore the potential benefits.

By improving the health of an aquatic organism, a certain pharmaceutical drug may alter the balance of species in an environment and have serious, cascading ecological consequences, according to the researchers from Ume University in Sweden.

Lead author of the paper Dr Jonatan Klaminder, said: "Ecotoxicological tests were designed with traditional toxic contaminants in mind, such as heavy metals and dioxins, which have historically been the major apparent threat against aquatic organisms in surface waters.

"Pharmaceuticals, which are designed to improve health, are a new group of contaminants that do not necessarily fit into the traditional view.

"I think there is a 'bandwagon effect' within the research community where the old test and the traditional view of a contaminant is routinely used without reflection about the conceptual flaw implicit in the methods."

In their study, the researchers retrieved two-year-old Eurasian perch from a lake in Sweden and randomly exposed them to high and low concentrations of Oxazepam.

Oxazepam is a benzodiazepine which is commonly used to treat anxiety and insomnia in humans and regularly contaminates surface waters via treated wastewater effluent. The researchers have previously shown that the drug can increase the activity and boldness of Eurasian perch.

In this study, the low concentration of Oxazepam was below that measured in treated effluent water in Europe.

The researchers also collected eggs, or roe strings, from a separate population of perch and exposed them during the first nine days of embryonic development to three different concentrations of Oxazepam. After hatching, a random group of the fry were collected and analysed.

Results showed that mortality rates were high among hatched fry corresponding to mortality rates found among perch fry in natural populations and relatively high among the two-year-old perch, but were significantly reduced by Oxazepam exposure in comparison to the control group of fish who were not exposed.

In the hatched fry, mortality was lower in the high concentration treatment than in the control and low concentration treatments. In the two-year-old perch, mortality was lower in both the low and high concentrations compared to the control.

Co-author of the study Tomas Brodin, who was the ecologist in the research team, said: "A therapeutic effect leading to increased survival of one species may generate a proportional increase in mortality of that species' prey, which may have cascading ecological consequences that need consideration.

"A new, conceptual view of ecotoxicological testing should include the possibility that a substance can improve the health of an organism and make individuals affected by contamination more competitive than non-affected individuals."

"Even though our study focused on one single pharmaceutical contaminant, it is possible that similar effects could be induced by exposure to a whole range of pharmaceuticals that find their way into surface waters, such as antibiotics, painkillers, anti-inflammatory drugs, hormones and antidepressants. Our conceptual view of a pollutant has, up until now, blocked us from testing for similar effects at environmentally relevant concentrations."


'/>"/>

Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics
Source:Eurekalert

Related biology news :

1. New book from CSHLPress provides a solution for informatics anxiety
2. Switching off anxiety with light
3. Wen Dan Tang improves insomnia-related anxiety
4. Neurobiologists find chronic stress in early life causes anxiety, aggression in adulthood
5. Rising ocean acidification leads to anxiety in fish
6. An important discovery related to anxiety disorders and trauma
7. Stress early in life leads to adulthood anxiety and preference for comfort foods
8. Portion of hippocampus found to play role in modulating anxiety
9. Gene associated with high anxiety can have protective effect on the battlefield
10. Study finds how BPA affects gene expression, anxiety; Soy mitigates effects
11. New model synapse could shed light on disorders such as epilepsy and anxiety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... , April 4, 2017 KEY FINDINGS ... anticipated to expand at a CAGR of 25.76% during ... diseases is the primary factor for the growth of ... report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global ... product, technology, application, and geography. The stem cell market ...
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University ... adopting ground breaking 3D fingerprint minutiae recovery and matching technology, pushing ... for use in identification, crime investigation, immigration control, security of access ... ... A research team led by Dr Ajay ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North Carolina, ... Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially available Hi-C ... software to perform Hi-C metagenome deconvolution using their own facilities, supplementing the ...
Breaking Biology Technology: