Navigation Links
Water is 'designer fluid' that helps proteins change shape, scientists say
Date:8/6/2008

l Angewandte Chemie.

Terahertz spectroscopy provides a window on protein-water rearrangements during the folding process, such as breaking protein-water-hydrogen bonds and replacing them with protein-protein-hydrogen bonds, Gruebele said. The remaking of hydrogen bonds helps organize the structure of a protein.

In tests on ubiquitin, a common protein in cells, the researchers found that water molecules bound to the protein changed to a native-type arrangement much faster than the protein. The water motion helped establish the correct configuration, making it much easier for the protein to fold.

"Water can be viewed as a 'designer fluid' in living cells," Gruebele said. "Our experiments showed that the volume of active water was about the same size as that of the protein."

The diameter of a single water molecule is about 3 angstroms (an angstrom is about one hundred-millionth of a centimeter), while that of a typical protein is about 30 angstroms. Although the average protein has only 10 times the diameter of a water molecule, it has 1,000 times the volume. Larger proteins can have hundreds of thousands times the volume. A single protein can therefore affect, and be influenced by, thousands of water molecules.

"We previously thought proteins would affect only those water molecules directly stuck to them," Gruebele said. "Now we know proteins will affect a volume of water comparable to their own. That's pretty amazing."


'/>"/>

Contact: James E. Kloeppel
kloeppel@illinois.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2

Related biology news :

1. Freshwater supplies threatened in central Pacific
2. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
3. Innovative civil engineering application promises cleaner waters
4. Safe water: simpler method for analyzing radium in water samples cuts testing time
5. Researchers find new taste in fruit flies: carbonated water
6. Low oxygen in coastal waters impairs fish reproduction
7. Extra gene copies were enough to make early humans mouths water
8. Acid rain has a disproportionate impact on coastal waters
9. HARDY rice: less water, more food
10. New microsensor measures volatile organic compounds in water and air on-site
11. Alternative methods proposed to detect pesticides and antibiotics in water and natural food
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... 2015 Research and ... the "Huawei Ascend Mate 7 Fingerprint Sensor ... offering. Huawei,s technological choice for the ... than Apple,s and Samsung,s one. The Ascend Mate ... Fingerprint Cards, a main actor in capacitive sensing ...
(Date:6/23/2015)... BEACH GARDENS, Fla. , June 23, ... multi-factor identity management and authentication solutions, today announced ... Altus strong, multi-factor authentication solution.  The enhancements ... of use of the DigitalPersona Altus platform ... biometric reader compatibility. In today,s ...
(Date:6/17/2015)... , June 17, 2015  Synaptics Inc. ... interface solutions, today announced that Xiaomi, one of ... Synaptics ® ClearPad ® family of ... driver integrated circuits (DDICs) for its latest smartphones, ... leveraging ClearPad for full in-cell display solutions and ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... St. Michael,s hospital have identified 29 proteins that are ... cancer. The discovery will help physicians recognize which tumours ... patients with more intensive treatment and closer followup., "Metastatic ... malignancies and patients have dismal prognosis," said Dr. George ...
... New research that relied in part on satellite images suggests ... the 1800s, is one cause for the larger, hotter and ... of the American West. The arid region covers about 230,000 ... of Utah, Colorado, Idaho, California and Oregon. Bethany Bradley, ...
... fine arts and the exact sciences may appear an ... both. Prof. Karen Avraham and PhD candidate Shaked Shivatzki ... this truth when creating Hearing and Deafness: Structure and ... of Human Genetics art competition. Their work was awarded ...
Cached Biology News:Tracking invasive cheatgrass role in larger, more frequent Western fires 2Tracking invasive cheatgrass role in larger, more frequent Western fires 3Embracing the art of science 2
(Date:6/29/2015)... , June 29, 2015 BioNano Genomics, ... of top research institutes, announced today that a collaboration ... Sinai resulted in the creation of the first comprehensive ... single DNA molecule methods for sequencing and genome mapping. ... provided the comprehensive analysis of the contiguous diploid human ...
(Date:6/29/2015)... , June 29, 2015  Neuralstem, Inc. (NYSE ... technology to develop small molecule and cell therapy treatments ... has been approved for listing on the NASDAQ Capital ... will continue to trade on the NYSE MKT until ... the NASDAQ Capital Market is expected to commence on ...
(Date:6/29/2015)... Calif. , June 29, 2015   Veracyte, ... company pioneering the field of molecular cytology, today announced ... News Group,s prestigious Top Workplaces list for the second ... Workplace winners based solely on an annual survey of ... and honored that the degree to which Veracyte values ...
(Date:6/26/2015)... Mass. , June 26, 2015  SeraCare ... vitro diagnostics manufacturers, today announced that it has ... with the National Cancer Institute (NCI), part of ... materials and positive controls for cancer assays.  The ... mix and accurately quantitate control DNA biosynthetics spiked ...
Breaking Biology Technology:BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 2BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3
... CA -- Science fiction fans still have another two months ... of actual science can feast their eyes now on the ... of a graphene crystal. Given that graphene single-layered sheets ... the key to the future of the electronics industry, the ...
... N.C., March 31 Cornerstone Therapeutics Inc. (Nasdaq: ... acquiring, developing and commercializing significant products primarily for the ... and Chief Executive Officer, will be presenting a corporate ... Biotech Industry Conference at 2:00 PM EDT on Thursday, ...
... Joint Venture to be funded by Cadila Pharmaceuticals ... $11 Million Capital Investment in Novavax , ROCKVILLE, ... NVAX ) announced today it has formed ... India) to develop, manufacture and market vaccines, pharmaceuticals ...
Cached Biology Technology:Spring 'blockbuster' movie now showing 2Spring 'blockbuster' movie now showing 3Spring 'blockbuster' movie now showing 4Spring 'blockbuster' movie now showing 5Cornerstone Therapeutics to Present at BioCentury's 2009 Future Leaders in the Biotech Industry Conference 2Novavax Announces New Capital Infusion Through a Strategic Alliance with Cadila Pharmaceuticals of India 2Novavax Announces New Capital Infusion Through a Strategic Alliance with Cadila Pharmaceuticals of India 3Novavax Announces New Capital Infusion Through a Strategic Alliance with Cadila Pharmaceuticals of India 4Novavax Announces New Capital Infusion Through a Strategic Alliance with Cadila Pharmaceuticals of India 5Novavax Announces New Capital Infusion Through a Strategic Alliance with Cadila Pharmaceuticals of India 6
EPA II Buffer is a diluent formulated to stabilize the activity of Chemicon horseradish peroxidase (HRP)-antibody conjugates at high conjugate dilution for extended periods....
... service, ExonHit can design custom microarrays to ... gene list. Proprietary algorithms are used ... probes from high quality, spliced cDNAs aligned ... contained in a custom SpliceArray is profiled ...
... Visualizer DX's sensitivity of DNA detection has been ... in an agarose gel can be detected > ... can be purified by organic solvent extraction or ... kits worked well.) DNA excised from agarose ...
... SPE Workstation is a modular, highly scalable, ... Utilizing 1ml or 3ml industry standard SPE ... 100 samples in less than two hours ... 10 cartridges, and up to 10 modules ...
Biology Products: