Navigation Links
Water, water everywhere - but is it essential to life?
Date:4/13/2012

Proteins are large organic molecules that are vital to every living thing, allowing us to convert food into energy, supply oxygen to our blood and muscles, and drive our immune systems. Since proteins evolved in a water-rich environment, it is generally thought that they are dependent on water to survive and function.

Proteins consist of one or more polypeptides chains of amino acids held together by peptide bonds. If a protein in water is heated to temperatures approaching the boiling point of water, these chains will lose their structure and the protein will denature (unfold).

A classic example of denaturing occurs when an egg is hard-boiled: the structures of the proteins in the egg unfold with temperature and stick together creating a solid. In the egg's case, this process cannot be reversed however there are many examples where cooling the protein results in refolding of the structure.

Previously, it was thought that water was essential to the refolding process, however the Bristol findings suggest this isn't necessarily the case.

Using a spectroscopic technique called circular dichroism, Dr Adam Perriman of Bristol's School of Chemistry and colleagues have shown that the oxygen-carrying protein myoglobin can refold in an environment that is almost completely devoid of water molecules.

Dr Perriman said: "We achieved this by attaching polymer molecules to the surface of the protein and then removing the water to give a viscous liquid which, when cooled from a temperature as high as 155C, refolded back to its original structure.

"We then used the Circular Dichroism beamline (B23) at Diamond Light Source, the UK's national synchrotron science facility in Oxfordshire, to track the refolding of the myoglobin structure and were astounded when we became aware of the extremely high thermal resistance of the new material."

These findings could pave the way for the development of new industrial enzymes where hyper-thermal resistance would play a crucial role, in applications ranging from biosensor development to electrochemical reduction of CO2 to liquid fuels.


'/>"/>
Contact: Hannah Johnson
hannah.johnson@bristol.ac.uk
0044-117-928-8896
University of Bristol
Source:Eurekalert

Related biology news :

1. Water, fair and foul
2. Inventor honored for tech improving access to clean water, healthcare, and business development in India
3. Discovery may lead to safer drinking water, cheaper medicine: Queens University researchers
4. Polymer-based filter successfully cleans water, recovers oil in Gulf of Mexico test
5. Pitt researcher says simple polymer-based filter successfully cleans water, recovers oil in Gulf of Mexico tests
6. Water, water everywhere focus of new sustainability project
7. When worms stick together and swim on thin water, what happens and why does it matter?
8. The green machine: Algae clean wastewater, convert to biodiesel
9. Water, water, everywhere… but is it safe to drink?
10. From a bucket of seawater, new understanding of the ocean
11. Database of water, wastewater pipeline infrastructure systems to be launched Sept. 1
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... Oct. 4, 2017  GCE Solutions, a global clinical research organization ... document anonymization solution on October 4, 2017. Shadow is designed to ... comply with policy 0070 of the European Medicines Agency (EMA) in ... ... ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... today announces publication of a United States multicenter, prospective clinical study that ... disposable, point-of-care diagnostic test capable of identifying clinically significant acute bacterial and ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
Breaking Biology Technology: