Navigation Links
Washington University scientists first to sequence genome of cancer patient
Date:11/5/2008

tients age. According to the American Cancer Society, the five-year survival rate for AML is 21 percent.

Despite advances in the genetic understanding of many cancers, scientists have learned very little about the genetic basis of AML. "After years of genetic studies of AML looking at genes of interest, we were getting no closer to uncovering the molecular underpinnings of the disease," Ley says. "We felt that with new genome sequencing technology, now was the time to take a whole-genome approach."

Based on genetic testing with traditional methods at the study's outset, the patient was known to have two mutations that are common among AML patients, an indicator she had a typical subtype of the disease, and one of the many reasons why her genome was selected for sequencing.

The researchers sequenced the patient's full genome, meaning DNA from both sets of chromosomes, using genetic material obtained from a skin sample. This gave the scientists a reference DNA sequence to which they could compare genetic alterations in the patient's tumor cells, taken from a bone marrow sample that was comprised only of tumor cells. Both samples were obtained before the patient received cancer treatment, which can further damage DNA.

The scientists then looked for genetic differences - points of single base changes in the DNA - in the patient's tumor genome compared with her normal genome. Of the nearly 2.7 million single nucleotide variants in the patient's tumor genome, almost 98 percent also were detected in DNA from the patient's skin sample, thus narrowing the number of variants that required further study to about 60,000.

Using sophisticated software and analytical tools, some of which the researchers developed specifically for this project, they identified the 10 mutations (including the two previously known genetic mutations that are common to her leukemia subtype but do not directly cause the disease) by looking for single base DNA
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. TGen and Washington University researchers discover new approach to treating endometrial cancer
2. Analysis of Lake Washington microbes shows the power of metagenomic approaches
3. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
4. Washington University unveils draft sequence of corn genome
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Missouri board grants Washington University Sustainability Center $3 million
7. Washington University, 2 industries, team to clean up mercury emissions
8. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
9. First IEEE-USA Innovation Forum coming to Washington area in November
10. Syracuse University researchers discover new way to attack some forms of leukemia
11. Indiana University research at American Public Health Association meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Washington University scientists first to sequence genome of cancer patient
(Date:5/20/2015)... OXFORD, Conn. , May 20, 2015 ... "Company") announces that its wholly owned subsidiary, 3D-ID LLC, ... contractor under Team Battelle for the biometrics technology portion ... Unrestricted Suite Contract from the Department of the Army. ... facial recognition products developed for government, law enforcement and ...
(Date:5/19/2015)... , May 19, 2015  Technology is rapidly advancing, ... and in the cloud. Passwords and their management are ... OTP and standards-based specifications such as those developed by ... use of passwords presents for BYOD, COPE, IoT, and ... biometric identity protocol. In response to ...
(Date:5/18/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2
... oral drug therapy called fenobam has shown promising initial results ... patients with Fragile X syndrome (FXS). Findings of the ... Center and the University of California, Davis, Medical Center are ... Journal of Medical Genetics . Results ...
... Human Genome Center at Shanghai (South Center, hereafter) was ... in Shanghai. To commemorate this important event, ,which marks ... specially organize a series of mini-reviews for ,this special ... attention of the Chinese life science research workers ,to ...
... MADISON, WI, JANUARY 5, 2009 Currently, plant ... ecological risks from chemical pesticides to nontarget plants ... plants. Protection of the plant development and reproduction ... protection of animals. Past research conducted by the ...
Cached Biology News:Promising new drug being evaluated as possible treatment option for fragile X syndrome 2Human genomics in China 2Human genomics in China 3Human genomics in China 4Human genomics in China 5Human genomics in China 6Human genomics in China 7Human genomics in China 8Human genomics in China 9Human genomics in China 10Human genomics in China 11
(Date:6/1/2015)... , June 1, 2015  Novartis is ... study of CTL019, an investigational chimeric antigen receptor ... in the treatment of specific types of hard-to-treat ... by the University of Pennsylvania,s Perelman School of ... (r/r) diffuse large B-cell lymphoma (DLBCL) and follicular ...
(Date:6/1/2015)... , June 1, 2015  The Val Skinner Foundation ... innovative science curriculum for high school students focused on ... th annual LIFE Event (LPGA Pros in the ... Country Club in West Caldwell, N.J. ... biggest stars raised more than $500,000 on Monday, bringing ...
(Date:6/1/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/9kv3rl/global ... "Global Bioinformatics Market 2015-2019" report to their ... bioinformatics market to grow at a CAGR of ... a field of science that includes computational analysis ... in DNA form and protein sequences in various ...
(Date:6/1/2015)... , June 1, 2015  Boston-based Veritas Genetics ... testing industry and bring personalized medicine and prevention ... control of their health. Beginning with its first ... ovarian cancer risk, Veritas Genetics is making its ... expanding the amount of genetic data which will ...
Breaking Biology Technology:Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 2Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 3Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 4Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 5Novartis highlights CTL019 data showing its potential in the treatment of specific types of hard-to-treat non-Hodgkin lymphoma 6Val Skinner Foundation Announces Partnership With Discovery Education 2Global Bioinformatics Market 2015-2019 - Rapid Developments in Molecular Diagnostics 2Global Bioinformatics Market 2015-2019 - Rapid Developments in Molecular Diagnostics 3Veritas Genetics To Advance Precision Medicine And Disease Prevention 2Veritas Genetics To Advance Precision Medicine And Disease Prevention 3
... Genetic testing market is projected to grow at a healthy pace ... by growing incidence of genetic diseases and growing consumer awareness and ... ... CA (PRWEB) October 30, 2008 -- Genetic testing, which of-late has ...
... turned into bioethanol, a renewable fuel that can be produced ... or diesel. This gives the olive processing industry an opportunity ... in olive stones it generates every year and sets a ... from the Universities of Jan and Granada in Spain show ...
... (NYSE:,GSK) (LSE: GSK) and Genelabs Technologies, Inc. (Nasdaq: ... into a definitive agreement pursuant to which,GSK will ... 35,million) through a tender offer of $1.30 per ... effort to develop and deliver novel,therapies against the ...
Cached Biology Technology:Genetic Testing Market to Exceed $6.6 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 2Genetic Testing Market to Exceed $6.6 Billion by 2015, According to New Report by Global Industry Analysts, Inc. 3Powered by olive stones? Turning waste stones into fuel 2GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 2GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 3GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 4
... Arrays can be used to test the ... and sera that are commonly used as ... contains spots for 21 different protein preparations ... antibody crossreactivity and species specificity, QC of ...
... based on PI's experience in high-resolution parallel ... decade. PI Hexapods were originally used in ... over wide ranges in small step sizes. ... with 3 m minimum incremental motion (combined ...
... coating using advanced automated high throughput microplate processing equipment that ... also accommodate virtually any lot size of the following formats ... 8 and 12 well strips, ... 384 well microplate, ...
... a full length insert sequencing service for ... and fosmids. Agencourt utilizes unique library ... There are several features that allow ... with rapid turnaround including our patented magnetic ...
Biology Products: