Navigation Links
Washington University scientists first to sequence genome of cancer patient
Date:11/5/2008

tients age. According to the American Cancer Society, the five-year survival rate for AML is 21 percent.

Despite advances in the genetic understanding of many cancers, scientists have learned very little about the genetic basis of AML. "After years of genetic studies of AML looking at genes of interest, we were getting no closer to uncovering the molecular underpinnings of the disease," Ley says. "We felt that with new genome sequencing technology, now was the time to take a whole-genome approach."

Based on genetic testing with traditional methods at the study's outset, the patient was known to have two mutations that are common among AML patients, an indicator she had a typical subtype of the disease, and one of the many reasons why her genome was selected for sequencing.

The researchers sequenced the patient's full genome, meaning DNA from both sets of chromosomes, using genetic material obtained from a skin sample. This gave the scientists a reference DNA sequence to which they could compare genetic alterations in the patient's tumor cells, taken from a bone marrow sample that was comprised only of tumor cells. Both samples were obtained before the patient received cancer treatment, which can further damage DNA.

The scientists then looked for genetic differences - points of single base changes in the DNA - in the patient's tumor genome compared with her normal genome. Of the nearly 2.7 million single nucleotide variants in the patient's tumor genome, almost 98 percent also were detected in DNA from the patient's skin sample, thus narrowing the number of variants that required further study to about 60,000.

Using sophisticated software and analytical tools, some of which the researchers developed specifically for this project, they identified the 10 mutations (including the two previously known genetic mutations that are common to her leukemia subtype but do not directly cause the disease) by looking for single base DNA
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. TGen and Washington University researchers discover new approach to treating endometrial cancer
2. Analysis of Lake Washington microbes shows the power of metagenomic approaches
3. 5th Annual World Health Care Congress April 21-23, Washington, D.C.
4. Washington University unveils draft sequence of corn genome
5. Washington University increases fleet of Roche Genome Sequencer FLX Systems
6. Missouri board grants Washington University Sustainability Center $3 million
7. Washington University, 2 industries, team to clean up mercury emissions
8. DHS Begins Collecting 10 Fingerprints From International Visitors at Washington Dulles International Airport
9. First IEEE-USA Innovation Forum coming to Washington area in November
10. Syracuse University researchers discover new way to attack some forms of leukemia
11. Indiana University research at American Public Health Association meeting
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Washington University scientists first to sequence genome of cancer patient
(Date:9/30/2014)... runoff in Hawaii is causing tumors in endangered sea ... published Tuesday in the peer-reviewed open-access journal PeerJ ... in algae that the turtles eat, promoting the formation ... organs. , Scientists at Duke University, the University of ... conducted the study to better understand the causes ...
(Date:9/30/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich report that a new ... sensitive to chemotherapeutic drugs. They have also pinpointed ... target for anti-tumor agents. , Researchers led ... Sieber of the Technische Universitt Mnchen have identified ... new weapon in the fight against malignant tumors. ...
(Date:9/30/2014)... with IVF? Here,s some hope: A new research report ... FASEB Journal , explains how scientists developed a ... which induced embryo development in human and mouse eggs ... the sperm cell during fertilization. , "We believe that ... shift in our understanding of human fertilization by providing ...
Breaking Biology News(10 mins):Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Cancer therapy: Driving cancer cells to suicide 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... significantly advance our understanding of the genetic basis of ... past year. They are the users of a web-based ... McGill School of Computer Science and collaborator Mathieu Blanchette. ... contribute to scientific research by arranging multiple sequences of ...
... fruit flies use to sense heat and chemicals may someday ... mosquitoes. , In the current issue of Nature , ... at Brandeis University and his team, spearheaded by KyeongJin Kang ... flies distinguish the warmth of a summer day from the ...
... 2011   Security Management Systems (SMS) , a ... an advanced data center security system for Oracle ... Services Corporation. Based in Somerset, New ... providing Oracle-based business operations solutions and information systems, ...
Cached Biology News:Video game players advancing genetic research 2Addressing pain and disease on the fly 2Security Management Systems (SMS) Completes Oracle Data Center Security Project for Core Services Corporation 2Security Management Systems (SMS) Completes Oracle Data Center Security Project for Core Services Corporation 3
(Date:9/30/2014)... Pacific Northwest Biotechnology, LLC - Product ... Markets Direct,s, ,Pacific Northwest Biotechnology, LLC - Product ... the Pacific Northwest Biotechnology, LLC,s pharmaceutical research and ... on the current therapeutic developmental pipeline of Pacific ... various stages, therapeutics assessment by drug target, mechanism ...
(Date:9/30/2014)... 30, 2014 Shimadzu Scientific Instruments ... easy-to-use and highly precise tool for measuring displacement ... elongation. With 1000-mm maximum movement distance, the DSES-1000 ... a gauge length of 10 mm. In addition, ... above 50-mm stroke and within +/- 100 µm ...
(Date:9/30/2014)... the last decade, the laboratory filtration market is experiencing ... acceptance of new filtration technologies in end users market. ... catalyzing the growth of laboratory filtration market. , The ... a strong CAGR during the forecast period of 2014-2019 ... 2019. The market is mainly driven by the increasing ...
(Date:9/30/2014)... 2014 Follow us on LinkedIn ... type of cholesterol carrier or lipoprotein in the blood. ... cholesterol levels in the body, especially along the walls ... attack and other cardiovascular disorders. Cardiovascular Diseases (CVD) is ... cholesterol levels on a regular basis, to assess an ...
Breaking Biology Technology:Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... LI-COR(R) Biosciences announces,an enhanced matching funds ... $1.75 million in matching funds is available ... each qualifying institution. The,Genomics Education Matching Funds ... to help colleges acquire LI-COR DNA sequencing ...
... PharmBIO Products Launches Unique Online Configurator For the ... ... Gore PharmBIO Products has,launched an industry first -- an ... configuring fluid,assemblies for biopharmaceutical manufacturers., The GORE(TM) STA-PURE(SM) Bioprocess ...
... support advancement to Phase 2 -, - Results of ... BRISBANE, Calif., Sept. 24 InterMune, Inc.,(Nasdaq: ... and,in-vitro studies of ITMN-191 (R7227) accepted for presentation at ... Study of Liver Diseases,(AASLD, Oct. 31 - Nov. 4 ...
Cached Biology Technology:Gore's Legacy of Innovation Extends From Products to Processes 2Gore's Legacy of Innovation Extends From Products to Processes 3InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting 2InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting 3InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting 4InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting 5InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting 6
... temperature control for microbiology and cell culture. ... is suitable for DASGIP bioreactors from 150 ... temperature ranges from approximately 10 °C to ... with an individual electrical heating element with ...
... gel stain is a sensitive nucleic acid ... to RNA and low background in gels, making ... polyacrylamide gels using laser scanners or standard UV ... mL unit size (S-7568) and a special packaging ...
... reports the data from any one of IITC ... recorder. The final data is sent from the ... is automatic for Systolic, Mean, Heart Rate while ... is always in the position to override the ...
Sirtuin 7 (SIRT7) Rabbit anti-Human Polyclonal Antibody Immunogen: Synthetic peptide - KLH conjugated Family: Other Recommended Storage: Long term: -20C; Short term: +4C...
Biology Products: