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Washington University increases fleet of Roche Genome Sequencer FLX Systems
Date:2/7/2008

he Centers system improvements will include an increase in sequence read length beyond 400 base pairs and a dramatic increase in the number of sequencing reads per instrument run. Using a combination of reagent and software improvements, it is expected that the current Genome Sequencer FLX will generate more than 1 billion bases per day.

As part of the early access program, the Genome Sequencing Center plans to resequence several strains of Caenorhabditis elegans, a small nematode that has been previously used as a genetic model organism.

By sequencing several different strains of C. elegans, we will be able to not only detect the smaller genetic variations such as single nucleotide polymorphisms, but identify the larger genome rearrangements that may also contribute to phenotypes, said Wilson. With the longer 400 base pair read lengths, we can start to assemble the genomes using a de novo approach, eliminating the need to remap the sequences to a reference genome that can lead to errors.

The new Genome Sequencer FLX systems will also be used in a number of projects studying the human microbiome at the Genome Sequencing Center. These projects are leading the way to the National Institutes of Health Human Microbiome Project, one of the new NIH Roadmap Initiatives. The goals of these projects are to characterize the microbial organisms that live within and on the human body, and study how the communities they form contribute to health and disease. It is estimated that there are nearly a trillion microbial organisms within a healthy human adult.

The GS FLX system has become a dominant platform for sequencing microbial genomes, providing a fast, accurate, and economical way to sequence a large and diverse range of organisms, said George Weinstock, Associate Director at the Genome Sequencing Center at Washington University School of Medicine. One of the additional benefits of the GS FLX is in its application to sequencing complex
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Contact: Lori McLaughlin
lori.mclaughlin@roche.com
317-521-3112
Roche Diagnostics
Source:Eurekalert

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