Navigation Links
Want to slow aging? New research suggests it takes more than antioxidants
Date:7/6/2010

Don't put down the red wine and vitamins just yet, but if you're taking antioxidants because you hope to live longer, consider this: a new study published in the June 2010 issue of the journal GENETICS (http://www.genetics.org) casts doubt on the theory that oxidative stress to our tissues shortens lifespan. That's because researchers from McGill University in Canada have identified mutations in 10 different genes of worms (genes believed to have counterparts in humans) that extend their lifespan without reducing the level of oxidative stress the worms suffer. The results contradict the popular theory that production of toxic reactive oxygen species in tissues is responsible for aging.

"We hope that our study will help in tempering the undue emphasis put on the notion that oxidative stress causes aging and thus that antioxidants could combat aging," said Siegfried Hekimi, Ph.D, the senior author of the study from the Department of Biology at McGill University in Montreal. "We also hope that the genes we have discovered can be used in the future to modulate energy metabolism in a way that can help delay the health issues linked to aging, and possibly increase lifespan itself."

To make their discovery, the scientists exposed a passel of worms (Caenorhabditis elegans) to a chemical that causes random changes in its DNA, and looked among the mutagenized worms for those appearing to have a slow rate of metabolism, manifested in their slow development and slow behavioral responses. They then identified the mutations in these worms that caused this effect, revealing 10 distinct genes involved in metabolism. The scientists' expected that the slowly metabolizing worms would have less oxidative stress, but to the investigators' surprise that was not the case. This suggests that a slow rate of living and reduced energy metabolism is sufficient to increase longevity, even when oxidative stress is not reduced.

"It looks like there's more truth to the clich, 'slow and steady wins the race,' than we imagined," said Mark Johnston, Editor-in-Chief of the journal GENETICS. "This research suggests that if we just eat less, we may not have to suffer eating all that broccoli simply for its antioxidants."


'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Genetics Society of America
Source:Eurekalert

Related biology news :

1. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
2. WSU researchers use super-high pressures to create super battery
3. Cell signaling classification system gives researchers new tool
4. Ethical issues ignored in teaching, research of sustainability
5. Reprogrammed human blood cells show promise for disease research
6. New book provides summary of research into the origins of life on Earth
7. Depressed mice could aid research on drug-resistant depression in humans
8. NY state the focus of Congressional hearing on how research and innovation fuel local economies
9. DOE awards UC San Diego consortium $9 million for algal biofuels research
10. Researchers discover how insulin-producing cells increase during pregnancy
11. Researchers develop accurate way to predict the age when women will hit the menopause
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... The Academy of Model Aeronautics (AMA) ... Model Aviation Day will take place from 9 a.m. to 2 p.m. at the ... for all ages. , Aviation Adventure Day will be packed with entertaining activities for ...
(Date:7/17/2017)... (PRWEB) , ... July 17, 2017 , ... ... are characterized by a wide range of overlapping clinical features. The advancement of ... in the field of NDD research and testing. , However, designing a ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... its long-standing innovation strategy. A website (openinnovation.pioneer.com) dedicated to connecting third-party ... areas – trait discovery, plant breeding, enabling technologies, biologicals and digital solutions. , ...
(Date:7/15/2017)... ... July 15, 2017 , ... Cuvette manufacturer ... During this time, the people at FFS have learned that their biggest asset ... at FFS are able to launch new products to meet the changing needs of ...
Breaking Biology Technology: