Navigation Links
Want to slow aging? New research suggests it takes more than antioxidants
Date:7/6/2010

Don't put down the red wine and vitamins just yet, but if you're taking antioxidants because you hope to live longer, consider this: a new study published in the June 2010 issue of the journal GENETICS (http://www.genetics.org) casts doubt on the theory that oxidative stress to our tissues shortens lifespan. That's because researchers from McGill University in Canada have identified mutations in 10 different genes of worms (genes believed to have counterparts in humans) that extend their lifespan without reducing the level of oxidative stress the worms suffer. The results contradict the popular theory that production of toxic reactive oxygen species in tissues is responsible for aging.

"We hope that our study will help in tempering the undue emphasis put on the notion that oxidative stress causes aging and thus that antioxidants could combat aging," said Siegfried Hekimi, Ph.D, the senior author of the study from the Department of Biology at McGill University in Montreal. "We also hope that the genes we have discovered can be used in the future to modulate energy metabolism in a way that can help delay the health issues linked to aging, and possibly increase lifespan itself."

To make their discovery, the scientists exposed a passel of worms (Caenorhabditis elegans) to a chemical that causes random changes in its DNA, and looked among the mutagenized worms for those appearing to have a slow rate of metabolism, manifested in their slow development and slow behavioral responses. They then identified the mutations in these worms that caused this effect, revealing 10 distinct genes involved in metabolism. The scientists' expected that the slowly metabolizing worms would have less oxidative stress, but to the investigators' surprise that was not the case. This suggests that a slow rate of living and reduced energy metabolism is sufficient to increase longevity, even when oxidative stress is not reduced.

"It looks like there's more truth to the clich, 'slow and steady wins the race,' than we imagined," said Mark Johnston, Editor-in-Chief of the journal GENETICS. "This research suggests that if we just eat less, we may not have to suffer eating all that broccoli simply for its antioxidants."


'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Genetics Society of America
Source:Eurekalert

Related biology news :

1. Hips dont lie: Researchers find more accurate technique to determine sex of skeletal remains
2. WSU researchers use super-high pressures to create super battery
3. Cell signaling classification system gives researchers new tool
4. Ethical issues ignored in teaching, research of sustainability
5. Reprogrammed human blood cells show promise for disease research
6. New book provides summary of research into the origins of life on Earth
7. Depressed mice could aid research on drug-resistant depression in humans
8. NY state the focus of Congressional hearing on how research and innovation fuel local economies
9. DOE awards UC San Diego consortium $9 million for algal biofuels research
10. Researchers discover how insulin-producing cells increase during pregnancy
11. Researchers develop accurate way to predict the age when women will hit the menopause
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ... 21 st .  The commercials will air on Bloomberg TV, ... the Street show. --> NXTD ) ("NXT-ID" or ... market, announces the airing of a new series of commercials ...
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 30, 2016 , ... The MIT bioLogic design ... the bioLogic team explored how bacterial properties can be applied to fabric and formed ... bacteria, which move in response to humidity change. The team harvested Natto cells and ...
(Date:4/29/2016)... 2016 According to a ... "Separation Systems for Commercial Biotechnology Market - Global ... 2015 - 2023", the separation systems for commercial ... in 2014 and is projected to expand at ... to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Intelligent Implant Systems announced ... FDA via 510(k) for sale in the United States. These components expand the ... fusions. With one-level sales beginning in October of 2015, the company has seen ...
(Date:4/28/2016)... NEW YORK , April 28, 2016 /PRNewswire/ ... biotechnology acceleration company reports the Company,s CEO  was ... capital titled Accelerators Enter When VCs Fear To ... Life Science Leader magazine is an ... work for everything from emerging biotechs to Big ...
Breaking Biology Technology: