Navigation Links
Walnuts slow prostate tumors in mice
Date:3/22/2010

(SACRAMENTO, Calif.) Walnut consumption slows the growth of prostate cancer in mice and has beneficial effects on multiple genes related to the control of tumor growth and metabolism, UC Davis and the U.S. Department of Agriculture Western Regional Research Center in Albany, Calif. have found.

The study, by Paul Davis, nutritionist in the Department of Nutrition and a researcher with the UC Davis Cancer Center, announced the findings today at the annual national meeting of the American Chemical Society in San Francisco.

Davis said the research findings provide additional evidence that walnuts, although high in fat, are healthful.

"This study shows that when mice with prostate tumors consume an amount of walnuts that could easily be eaten by a man, tumor growth is controlled," he said. "This leaves me very hopeful that it could be beneficial in patients."

Prostate cancer affects one in six American men. It is one in which environmental factors, especially diet, play an important role. Numerous clinical studies have demonstrated that eating walnuts -- rich in omega-3 polyunsaturated fats, antioxidants and other plant chemicals -- decreases the risk of cardiovascular disease. These findings prompted the U.S. Food & Drug Administration in 2004 to approve, for the first time, a qualified health claim for reducing heart disease risk for a whole food.

Davis fed a diet with whole walnuts to mice that had been genetically programmed to get prostate cancer. After 18 weeks, they found that consuming the human equivalent of 2.4 ounces of walnuts per day resulted in significantly smaller, slower-growing prostate tumors compared to mice consuming the same diet with an equal amount of fat, but not from walnuts. They also found that not only was prostate cancer growth reduced by 30 to 40 percent, but that the mice had lower blood levels of a particular protein, insulin-like growth factor (IGF-1), which has been strongly associated with prostate cancer. Additionally, Davis and his research colleagues looked at the effect of walnuts on gene activity in the prostate tumors using whole mouse gene chip technology, and found beneficial effects on multiple genes related to controlling tumor growth and metabolism.

"This is another exciting study from UC Davis nutrition researchers, where truly promising results that have a molecular footprint are having beneficial effects against cancer," said Ralph deVere White, UC Davis Cancer Center director and a prostate cancer researcher. "We have to find a way to get these kinds of studies on nutritional products funded so that we can truly evaluate their effects on cancer patients."

Davis, whose research was funded by a grant to UC Davis from the California Walnut Board, said additional research is needed to further explore how walnuts reduce tumor cell growth.

"The bottom line is that what is good for the heart -- walnuts -- may be good for the prostate as well," he said.


'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. VAI researchers develop tool to help study prostate cancer
2. LSUHSC researcher finds first inherited prostate cancer genetic mutation in African-American men
3. Dietary supplements discouraged for prostate cancer patients
4. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
5. Experimental drug shows promise against brain, prostate cancers
6. New synthetic molecules trigger immune response to HIV and prostate cancer
7. Rutgers to collaborate in $3.4 million effort to improve prostate cancer identification using MRI
8. Researchers find first evidence of virus in malignant prostate cells
9. USC researchers identify regulatory genetic sequences that may predict risk for prostate cancer
10. Newly discovered gene fusion may lead to improved prostate cancer diagnosis
11. Genetic factors implicated in survival gap for breast, ovarian or prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in ... professor in Harvard University’s Departments of Physics and Astronomy, has been selected for membership ... the winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
(Date:10/5/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... to cancer research with a month-long promotion supporting the advancement of breast cancer research ... use promo code PinkRibbon to get 10 percent off their purchase of every the ...
Breaking Biology Technology: