Navigation Links
Wallabies and bats harbor 'fossil' genes from the most deadly family of human viruses
Date:7/2/2010

BUFFALO, N.Y. -- Modern marsupials may be popular animals at the zoo and in children's books, but new findings by University at Buffalo biologists reveal that they harbor a "fossil" copy of a gene that codes for filoviruses, which cause Ebola and Marburg hemorrhagic fevers and are the most lethal viruses known to humans.

Published this week in the online journal BMC Evolutionary Biology, the paper ("Filoviruses are ancient and integrated into mammalian genomes") demonstrates for the first time that mammals have harbored filoviruses for at least tens of millions of years, in contrast to the existing estimate of a few thousand.

It suggests that these species, which maintain a filovirus infection without negative health consequences, could have selectively maintained these so-called "fossil" genes as a genetic defense.

The work has important implications for the development of potential human vaccines, as well as for the modeling of disease outbreaks and the discovery of emerging diseases, including new filoviruses.

"This paper identifies the first captured 'fossil' copies of filovirus-like genes in mammalian genomes," says Derek J. Taylor, PhD, associate professor of biological sciences in the UB College of Arts and Sciences and co-author. "Our results confirm for the first time that several groups of mammals, including groups such as marsupials that never colonized Africa, have had an association with filoviruses."

The UB co-authors say that if the rarely captured genes represent antiviral defenses or genomic scars from persistent infections, then the work opens up new possibilities for identifying reservoir species for filoviruses, which harbor the virus but remain asymptomatic.

"The reservoir for filovirus has remained a huge mystery," says Jeremy A. Bruenn, PhD, UB professor of biological sciences and co-author. "We need to identify it because once a filovirus hits humans, it can be deadly."

When the UB research
'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Cold Spring Harbor Protocols features Drosophila neurobiology methods
2. Wild sharks, redfish harbor antibiotic-resistant bacteria
3. Harbor seals whiskers as good at detecting fish as echolocating dolphins
4. Electrophoresis of RNA, avian imaging featured in Junes Cold Spring Harbor Protocols
5. Mays Cold Spring Harbor Protocols features plant gene expression methods, Xenopus imaging
6. Tissue engineering, imaging neuronal circuits featured in Cold Spring Harbor Protocols
7. From international harbor to native habitat
8. Protein-bait interactions, display libraries featured in Cold Spring Harbor Protocols
9. High-throughput analysis of gene regulation, DNA synthesis in Cold Spring Harbor Protocols
10. High-throughput genotyping, protein purification featured in Cold Spring Harbor Protocols
11. NY Gov. Paterson renews commitment to stem cell research in visit to Cold Spring Harbor Laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Wallabies and bats harbor 'fossil' genes from the most deadly family of human viruses
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... revenues for Q1 2015 attributed to somewhat higher than ... company in the year-end report 2014 that revenues for ... MSEK that the company reported for Q4 2014. The ... continue to be negative. The complete interim report will ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... of Pennsylvania School of Medicine & School of Engineering ... deliver drugs to tumors. By using a cylindrical-shaped carrier ... paclitaxel to an animal model of lung cancer ten ... findings have implications for drug delivery as well as ...
... vitamin was named, what is known about them ... public health, says Irwin Rosenberg, MD, University Professor, ... at the Jean Mayer USDA Human Nutrition Research ... on his presentation at the National Institutes of ...
... was published in an advance online edition of the Proceedings ... April 9, 2007. , The study provides new evidence that ... is activated by the protein SGT1, which also activates Resistance ... pathogens. The study also confirms structural similarities between the Nod1 ...
Cached Biology News:Penn researchers show how nanocylinders deliver medicine better than nanospheres 2Vitamins: Science doesn't always match policy 2Scripps research study shows humans and plants share common regulatory pathway 2Scripps research study shows humans and plants share common regulatory pathway 3
(Date:4/27/2015)... Ohio (PRWEB) April 27, 2015 ... of an agreement with Joslin Diabetes Center (“Joslin”) ... 2b study of Diasome’s novel Hepatocyte Directed Vesicle ... Type 1 diabetes. , Located in Boston, ... clinical care and education organization dedicated to the ...
(Date:4/24/2015)... and Tempe, AZ (PRWEB) April 24, 2015 ... and Arizona State University (ASU) have entered into an ... projects. , A memorandum of agreement signed by the ... distance learning, student success and other services particularly, though ... , “We have complementary strengths and a similar ...
(Date:4/24/2015)... MONTREAL , April 24, 2015 /CNW Telbec/ - Mirego, ... part of the making of three mobile app extensions for ... for its clients, Familiprix, OMSignal and MediaMiser, these ... information thanks to functions designed specifically for wrist use.  ... the Apple Watch is a highly customizable tactile smartwatch that ...
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
Breaking Biology Technology:Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2
... 5 Dynamic Alert,Limited (OTC Bulletin Board: DYMC) ... its target markets for its pharmaceutical product line-up. ... for enhancing rapid onset,through oromucosal absorption, topical applications, ... internal use. Some products will have,specific uses, while ...
... Dec. 5 Early clinical experience with the FDA,cleared ... of ultrasound guided cryoablation to completely eradicate,small, unifocal Invasive ... study was presented at the 94th Scientific Assembly and ... November 29 -,December 5, 2008. , ...
... Senesco Technologies, Inc. ("Senesco" or the "Company") (NYSE Alternext ... Agreement with the http://www.senesco.com ("Harris Moran") has ... recently announced corporate restructuring. , ... parent company, Limagrain, restructured its vegetable seed operations and ...
Cached Biology Technology:Dynamic Outlines Initial Target Markets for Pharmaceutical Cannabinoid Products 2Dynamic Outlines Initial Target Markets for Pharmaceutical Cannabinoid Products 3Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA 2Cryoablation of Early Invasive Ductal Breast Cancer With MRI Confirmation Shows Promising Clinical Benefits, According to Study Presented at RSNA 3Senesco and Harris Moran Mutually Agree to Terminate Development and License Agreement Due to Restructuring 2Senesco and Harris Moran Mutually Agree to Terminate Development and License Agreement Due to Restructuring 3
... service is for when you need to make ... their transformation efficiency. Our services for preparing competent ... applications. MCLab's custom competent cell service offers: ... Fast turnaround Quality control ...
... WR Cryoscope for molecular weight determinations for petroleum-based applications. Multiple solvents can be used, such ... ... ... ...
Growth Medium / Media...
... Sensitivity Laboratory Osmometer for 50 L samples. Operating head automatically rises at the end of determination; triple-point ... ... ... ...
Biology Products: