Navigation Links
WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
Date:5/9/2012

DETROIT Efforts to understand how the aging process affects the brain and cognition have expanded beyond simply comparing younger and older adults.

"Everybody ages differently. By looking at genetic variations and individual differences in markers of vascular health, we begin to understand that preventable factors may affect our chances for successful aging," said Wayne State University psychology doctoral student Andrew Bender, lead author of a study supported by the National Institute on Aging of the National Institutes of Health and now in press in the journal Neuropsychologia.

The report, "Age-related Differences in Memory and Executive Functions in Healthy APOE ε4 Carriers: The Contribution of Individual Differences in Prefrontal Volumes and Systolic Blood Pressure," focuses on carriers of the ε4 variant of the apolipoprotein (APOE) gene, present in roughly 25 percent of the population. Compared to those who possess other forms of the APOE gene, carriers of the ε4 allele are at significantly greater risk for Alzheimer's, dementia and cardiovascular disease.

Many studies also have shown that nondemented carriers of the APOE ε4 variant have smaller brain volumes and perform less well on cognitive tests than carriers of other gene variants. Those findings, however, are not consistent, and a possible explanation may come from examining interactions between the risky genes and other factors, such as markers of cardiovascular health. Prior research in typical samples of older adults has shown that indeed other vascular risk factors such as elevated cholesterol, hypertension or diabetes can exacerbate the impact of the APOE ε4 variant on brain and cognition, but it is unclear if such synergy of risks is present in healthy adults.

Thus, Wayne State researchers evaluated a group of volunteers from 19 to 77 years of age who self-reported as exceptionally healthy on a questionnaire that screened
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. KIT researchers succeed in realizing a new material class
2. Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
3. UCSB researchers find that less is more, for female cowbirds
4. Researchers discover first gene linked to missing spleen in newborns
5. Researchers pinpoint genetic pathway of rare facial malformation in children
6. Researchers find reducing fishmeal hinders growth of farmed fish
7. Researchers unveil new assessment for diagnosing malnutrition
8. Researchers show prebiotic can reduce severity of colitis
9. Game on! UCLA researchers use online crowd-sourcing to diagnose malaria
10. Americas clean energy policies need a reality check, say Stanford researchers
11. Researchers find potential dark side to diets high in beta-carotene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/28/2014)... National University of Singapore (NUS) have discovered a new ... laying direct developing eggs in live bamboo with narrow ... bush frog ( Raorchestes chalazodes ). This critically ... known to adopt this novel reproductive strategy. The findings ... Biological Journal of the Linnean Society , in October ...
(Date:10/28/2014)... juices are associated with a lower risk of developing ... of East Anglia (UEA). , Research published today ... flavanones (both subclasses of dietary flavonoids) significantly decrease their ... of cancer death among women. , The research ... between 25 and 55 for more than three decades. ...
(Date:10/27/2014)... German . ... via electrical signals, they communicate with each other at ... substances, the neurotransmitters, are stored in vesicles at the ... vesicles fuse with the cell membrane and release their ... synapses always have some readily releasable vesicles on standby. ...
Breaking Biology News(10 mins):NUS researchers discover for the first time that a rare bush frog breeds in bamboo 2NUS researchers discover for the first time that a rare bush frog breeds in bamboo 3Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2Synapses always on the starting blocks 2Synapses always on the starting blocks 3
... they know to fear the scent of a predator. But how ... cat is nearby? It,s a complex process that starts ... noses. But until now it wasn,t clear exactly how these scent ... a study to be published in Nature (available online ...
... is relatively common to come across petrol stations surrounded by ... Murcia (UM) have studied the effects of contamination at petrol ... noted in buildings less than 100 metres from the service ... which increases the risk of cancer have been recorded ...
... It,s the champagne of the cheese world and the ... like Stilton are literally under the microscope in a quest ... of Nottingham and The University of Northampton are working with ... distinctive taste, texture and smell. The scientists hope to ...
Cached Biology News:The brain knows what the nose smells, but how? Stanford researchers trace the answer 2The brain knows what the nose smells, but how? Stanford researchers trace the answer 3Petrol stations pollute their immediate surroundings 2The quest for the ultimate blue cheese 2
(Date:10/30/2014)... Oct. 30, 2014  Ardelyx, Inc. (NASDAQ: ... on cardio-renal, gastrointestinal and metabolic diseases, today announced ... results on Thursday, November 6, 2014. Following the ... live conference call and webcast at 4:30pm ET ... a business update. The live webcast ...
(Date:10/30/2014)... On October 26th at the Mid ... leading applied stem cell research scientist Neil Riordan, ... talks on New Techniques for Enhancing Stem Cell ... Cells. , Dr. Riordan focused on historical medical ... AlphaGEMS that include: wound healing; inflammation and pain ...
(Date:10/30/2014)... 30, 2014 James Sherley says he has ... tissue stem cell technology since his days as a principal ... in the late 1990’s. Sherley founded the ASCTC as ... holds all the intellectual property developed in Sherley’s research over ... Massachusetts Institute of Technology (MIT), and more recently as a ...
(Date:10/30/2014)... 30, 2014 Avure Technologies celebrates a year ... newest member of its fleet of high volume High Pressure ... anniversary as we return to PackExpo this year, which is ... Las Vegas,” said Jeff Williams, CEO at Avure. “Sales of ... pleased to be meeting the challenges of market demand for ...
Breaking Biology Technology:Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 2Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 3Riordan-McKenna Institute Founders, Neil Riordan, PhD and Orthopedic Surgeon, Dr. Wade McKenna Present at the Mid American Regenerative and Cellular Medicine Showcase 4Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 2Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 3Boston’s Adult Stem Cell Technology Center, LLC Introduces A New Technology for Monitoring Previously Elusive Adult Stem Cells 4In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
... BioTechnologies, Inc. (TriLink) and Lucigen Corporation (Lucigen) announced today ... for the use of TriLink,s CleanAmp™ dNTPs in Lucigen,s ... CleanAmp™ dNTPs are an innovative approach to Hot Start ... PCR assay with CleanAmp™ dNTPs, a Hot Start reaction ...
... DIEGO, July 28, 2011 Verenium Corporation (NASDAQ: ... commercialization of high-performance industrial enzyme solutions, today announced that ... its 5.5% Notes and approximately $3 million in principal ... very pleased to have taken another important step toward ...
... July 28, 2011 United Therapeutics Corporation (NASDAQ: ... ended June 30, 2011. "I,m pleased with the ... as the very good operating results we achieved," remarked Martine ... remain on track to reach our 2011 forecast for revenues ...
Cached Biology Technology:TriLink BioTechnologies, Inc. Announces License Agreement with Lucigen Corporation 2Verenium Announces Debt Repurchase 2Verenium Announces Debt Repurchase 3United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2011 Financial Results 7
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
... Dunbar (1994) • This book describes ... methods for preparing samples for protein ... radiometric and bioluminescence-enhanced detection systems are ... the detection and characterization of glycoprotein ...
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Human HAPLN1 MAb (Clone 316119) Protein Family: Hyaluronan (HA) & HA Binding Proteins, Proteoglycan Regulators...
Biology Products: