Navigation Links
WSU researchers find way to make cancer cells more mortal
Date:7/16/2010

SPOKANE, Wash.Washington State University researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors.

"Hopefully, we can make cancer cells die like normal cells," says Weihang Chai, an assistant professor in the WSU School of Molecular Biosciences and WWAMI medical education program in Spokane. "Basically, you make the cancer cell go from immortal to mortal."

Normal cells lose a little bit of their DNA every time they reproduce as the molecule's strands lose part of their protective tips, called telomeres. Eventually, the telomeres become too short, signaling to the cell to stop replicating and growing.

But cancer cells have a mechanism to keep their DNA strands from shortening, giving them a near eternal life. This is because the enzyme telomerase extends one strand of the cancer cell's DNA while other proteins help extend the second strand.

Chai and her colleagues, writing in the current issue of The EMBO Journal, say they have found a regulatory protein that controls the production of that second strand. They have also found a protein required to synthesize it.

If that second strand of DNA cannot be lengthened, says Chai, it behaves like a normal cell and dies a normal death. She says her team will now focus on developing a strategy to block the regulatory protein's function.


'/>"/>

Contact: Robert Strenge
rstrenge@wsu.edu
509-335-3583
Washington State University
Source:Eurekalert

Page: 1

Related biology news :

1. International AIDS Society and partners recognize outstanding researchers from around the world at AIDS 2010
2. Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages
3. CWRU dental researchers discover human beta defensins-3 ignite in oral cancer growth
4. In the ring: Researchers fighting bacterial infections zero in on microorganisms soft spots
5. Researchers use nanoparticles to shrink tumors in mice
6. Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation
7. Researchers apply computing power to crack egg shell problem
8. Mount Sinai researchers discover new way diseases develop
9. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
10. MSU researchers awarded $9.1 million grant to battle malaria in Malawi
11. Researchers calculate the cost of CO2 emissions, call for carbon tax
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... Medicine, Inc, a Baltimore-based bioinformatics company focused on ... a research collaboration with the international leader in ... CSBR). , "There are many companies utilizing advances ... TumorGraft technology is unique in a way that ... vast amounts of valuable data. Our bioinformatic analysis ...
(Date:11/5/2014)... has dedicated his career to understanding the Earth,s ... audience. , As deputy director and regional climatologist ... Desert Research Institute, Redmond has more than three ... dissemination of climate data to the general public. ... San Francisco on December 15-19, 2014 the American ...
(Date:11/4/2014)... University of Utah engineers developed the first room-temperature fuel ... electricity without needing to ignite the fuel. These new ... off-grid power and sensors. , A study of the ... Society journal ACS Catalysis . , Fuel cells ... a fuel and an oxygen-rich source such as air. ...
Breaking Biology News(10 mins):Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Jet-fueled electricity at room temperature 2
... help may be on the way. That,s because scientists ... promotes new bone growth. This opens the door to ... they are getting a workout. The research report describing ... Journal ( http://www.fasebj.org ). This research provides ...
... prevalent diabetes-induced complications in men; current estimates suggest that as ... degree of ED, and in many cases diabetics develop more ... drugs. Now, in a study appearing in the March ... Reserve University and Albert Einstein College of Medicine have identified ...
... radiated only 70 to 75 percent as much energy as it ... energy reaching the planet,s surface, all water on the planet should ... early Earth was awash in liquid water a planetary ocean ... output and kept Earth,s water wet. To explain this apparent ...
Cached Biology News:For osteoporosis patients, exercise pill one step closer to reality 2Early Earth absorbed more sunlight -- no extreme greenhouse needed to keep water wet 2Early Earth absorbed more sunlight -- no extreme greenhouse needed to keep water wet 3Early Earth absorbed more sunlight -- no extreme greenhouse needed to keep water wet 4
(Date:11/26/2014)... SonaCare Medical, a leading manufacturer of ... participated in the American Urology Association’s (AUA) surgical ... opinion leaders in urology presented on the latest ... masses while attendees had the opportunity to evaluate ... labs. Attendees at the Los Angeles, CA lab, ...
(Date:11/26/2014)... PA (PRWEB) November 25, 2014 The ... of its official conference and exposition mobile app, ... for free download in the App Store for iOS ... a valuable resource tool before, during and after the ... containing details on exhibiting companies, technical sessions, Conferee Networking ...
(Date:11/26/2014)... 2014 SoundConnect , an award ... to announce that Darren Suders has joined the team ... will drive the partner program through innovative ... , Darren brings more than 10-years of channel ... in channel operations, from policy development, to partner education ...
(Date:11/26/2014)... Theravalues Corporation est fier d,annoncer le lancement de ... Hi Europe 2014 (du 2 au 4 décembre à ... la plus biodisponible actuellement sur le marché, elle ... approuvés par les règlements européens. La ... racine de curcuma ( Curcuma longa ) qui ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Pittcon Releases 2015 Mobile App 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3
... 2 NicOx S.A.,(NYSE Euronext Paris: COX) ... with,DSM for the commercial manufacture and supply ... ingredient). Naproxcinod is NicOx, lead,investigational product and ... (CINOD) class of,anti-inflammatory agents, which recently achieved ...
... Inc., announced today the appointment of Ellen McDonald to ... Business Operations and Chief Business Officer, effective immediately. ... experience in the biopharmaceutical industry, with expertise heading business ... report to David J. Mazzo, Ph.D., the Company,s President ...
... Sheets: CGCP), a leading developer of surgical products used in ... the addition of veteran medical device executive and an experienced ... the Company,s Board of Directors, increasing the number of board ... Mr. Cohen, 49, has over 25 years of executive experience ...
Cached Biology Technology:NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 2NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 3NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 4Ellen McDonald Joins Regado Biosciences as Senior Vice President of Business Operations and Chief Business Officer 2Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 2Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 3
Mouse monoclonal antibody raised against a partial recombinant PUM2. NCBI Entrez Gene ID = PUM2...
...
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
... The Rotofor purification system with PowerPac 3000 ... protein separation and purification by liquid-phase isoelectric ... mini (18 ml) and standard (60 ml) ... electrode chambers, PowerPac 3000 power supply, 10 ...
Biology Products: