Navigation Links
WSU researchers discover key mechanism behind sleep
Date:9/14/2010

SPOKANE, Wash. Washington State University researchers have discovered the mechanism by which the brain switches from a wakeful to a sleeping state. The finding clears the way for a suite of discoveries, from sleeping aids to treatments for stroke and other brain injuries.

"We know that brain activity is linked to sleep, but we've never known how," said James Krueger, WSU neuroscientist and lead author of a paper in the latest Journal of Applied Physiology. "This gives us a mechanism to link brain activity to sleep. This has not been done before."

The mechanisma cascade of chemical transmitters and proteinsopens the door to a more detailed understanding of the sleep process and possible targets for drugs and therapies aimed at the costly, debilitating and dangerous problems of fatigue and sleeplessness. Sleep disorders affect between 50 and 70 million Americans, according to the Institute of Medicine of the National Academies. The Institute also estimates the lost productivity and mishaps of fatigue cost businesses roughly $150 billion, while motor vehicle accidents involving tired drivers cost at least $48 billion a year.

The finding is one of the most significant in Krueger's 36-year career, which has focused on some of the most fundamental questions about sleep.

Even before the dawn of science, people have known that wakeful activity, from working to thinking to worrying, affects the sleep that follows. Research has also shown that, when an animal is active and awake, regulatory substances build up in the brain that induce sleep.

"But no one ever asked before: What is it in wakefulness that is driving these sleep regulatory substances?" said Krueger. "No one ever asked what it is that's initiating these sleep mechanisms. People have simply not asked the question."

The researchers documented how ATP (adenosine triphosphate), the fundamental energy currency of cells, is released by active brain c
'/>"/>

Contact: James Krueger
krueger@vetmed.wsu.edu
509-358-7808
Washington State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. MIT researchers develop a way to funnel solar energy
2. Mount Sinai researchers analyze impact of chemical BPA in dental sealants used in children
3. Swine researchers seek answers to fibers low digestibility
4. Twins are intriguing research subjects for Notre Dame biometircs researchers
5. Researchers at UC Riverside find solution to cell death problem vexing stem cell research
6. Researchers at Childrens Hospital Los Angeles find diet-induced obesity accelerates leukemia
7. Researchers define role of CEP290 in maintaining ciliary function
8. Research about Brazilian marine biodiversity brings researchers from 5 countries together
9. Researchers identify how bone-marrow stem cells hold their breath in low-oxygen environments
10. Bochums researchers discover proton diode
11. U-M researchers receive largest single collection of psoriasis DNA samples
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
WSU researchers discover key mechanism behind sleep
(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
(Date:10/15/2014)... the pandemic risk from strains of influenza virus increases ... ourselves to become complacent that the most substantial threats ... , Influenza pandemics arise when a new virus strain ... immunity – spreads in the human population. There have ... the worst of which – the 1918 Spanish Flu ...
(Date:10/15/2014)... spreading rapidly and to an unexpected extent. The outbreak ... and the virus shows a new disease dynamic in ... this reason, the German National Academy of Sciences Leopoldina, ... and the Union of the German Academies of Sciences ... epidemic today. , In the statement the academies call ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... Luxembourg Centre for Systems Biomedicine (LCSB) of the University ... from which differentiated cells for instance skin cells ... cell types such as nerve cells, for example. ... computer-based instructions for reprogramming cells are of huge significance ...
... rats have long since been a standard animal model for ... years on average and high incidence of cancer. Naked mole ... African subterranean rodent has a maximum lifespan exceeding 30 years ... not a single incident of cancer has been detected makes ...
... central nervous system is injured, oligodendrocyte precursor cells (OPC) ... on demyelinated axons. Scientists at the Institute of Molecular ... now discovered that a distinct protein regulates the direction ... protein NG2, which is expressed at the surface of ...
Cached Biology News:Computational biology: Cells reprogrammed on the computer 2The naked mole-rat's secret to staying cancer free 2Scientists at Mainz University decode mechanisms of cell orientation in the brain 2
(Date:10/22/2014)... Hill, SC (PRWEB) October 22, 2014 ... expansion of its cardiovascular pharmacogenetics menu, which enables ... patient outcomes. With PCLS’s evidence-based results, healthcare ... needs and optimize their therapy, while minimizing risks ... In the U.S., according to the FDA [1] ...
(Date:10/22/2014)... , Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ... today announced next steps for its Oral Amphotericin ... from its in vitro work involving ... iCo now plans to complete pre clinical studies ... initial Phase 1A clinical trial, utilizing approximately $700,000 ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... INCLINE VILLAGE, Nev., Sept. 8 PDL BioPharma, ... guidance for the third quarter ended September 30, 2009 of ... third quarter of 2008. Royalty revenues are based on second ... for Synagis(R), which is marketed by MedImmune. When compared with ...
... NOVATO, Calif., Sept. 8 BioMarin Pharmaceutical Inc. (Nasdaq: ... will present a company update at the Morgan Stanley Healthcare Conference in ... , , Interested parties may access a ... the BioMarin website, www.BMRN.com . A replay of ...
... 8 Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) announced ... failure gout will be presented at the 2009 ACR/ARHP Annual Scientific ... posters will be presented during the "Treatment and Outcome" session on ... , Chronic Use of Pegloticase: Safety ...
Cached Biology Technology:PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 2PDL BioPharma Provides Third Quarter 2009 Revenue Guidance of Approximately $71 Million 3BioMarin to Present at the Morgan Stanley Healthcare Conference 2Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 2Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 3Multiple Abstracts Related to KRYSTEXXA(TM) Development and Treatment Failure Gout to be Presented at the 2009 ACR/ARHP Annual Scientific Meeting 4
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
...
...
... the 9, 10, 12, and 13 positions. It ... for the quantification of 9(S)-HODE by GC- or ... of linoleic acid in both plants and animals. ... an esterified component of membrane phospholipids and in ...
Biology Products: