Navigation Links
WSU receives DOD grant to determine common genetic link among Gulf War Illness patients
Date:4/11/2011

DETROIT For nearly two decades following the 1991 Gulf War, doctors noticed a trend in many of veterans of that conflict: an unexplainable cluster of symptoms including but not limited to chronic fatigue, memory loss, and depression. It wasn't until 2008 that a scientific panel from the U.S. Department of Veterans Affairs concluded that a third of American troops who served in the Gulf War were suffering from combinations of these symptoms, now recognized collectively as Gulf War Illness (GWI).

Now, Henry Heng, Ph.D., associate professor in WSU's Center for Molecular Medicine and Genetics, also of the Department of Pathology and Karmanos Cancer Institute in the School of Medicine, intends to discover GWI's mysterious biological cause. Heng was recently awarded a $900,000 grant from the U.S. Department of Defense to study whether GWI stems from genomic instability, which he believes is the common link among GWI patients.

After conducting an experiment for a program about Gulf War Illness broadcast on the Discovery Channel, Heng observed that patients who had GWI symptoms also tended to have extremely high levels of genomic instability, illustrated by increased chromosomal aberrations detected in their blood cells. "To our surprise, we found that all of the GWI patients tested showed extremely high levels of chromosomal abnormality that were as high or higher than some cancer patients," said Heng. The Discovery Channel program has received a great deal of attention from veteran groups.

Heng's hypothesis is also drawn from the genome theory, which suggests that complex disorders are not caused by individual genes, but rather by diverse factors not commonly shared and that affect the entire genome, which comprises the complete complement of genetic material of an organism within the nucleus and includes the genomic topology and the genetic network. When abnormal chromosomes form, the entire genome-defined system changes. "We propose that under the extreme environment of war, some individuals' genomes will become increasingly unstable, and war-induced genetic instability will lead to diverse disease traits that can be characterized as GWI," said Heng.

As his research on GWI progresses, Heng anticipates that his findings may make it possible to use simple blood samples to identify GWI patients. "Establishing GWI as a complex disorder and identifying its general causes will not only allow accurate diagnosis of this condition," said Heng, "but also move us toward reducing the prevalence of this condition in the future."


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
3. Kount Receives Patent for Device Fingerprinting
4. American College of Medical Genetics receives $13.5M NIH contract
5. Penn State receives new NASA astrobiology grant
6. Global Viral Forecasting Initiative receives $11M to implement pandemic early warning system
7. Vidaza receives positve opinion from European CHMP
8. Case Western Reserve receives Ellison Medical Foundation New Scholar in Aging award
9. Montana State partnership receives $66.9M for carbon sequestration
10. Oklahoma EPSCoR receives $20 million for biofuels research
11. UC Riverside rice geneticist receives high honor from US Department of Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
(Date:4/15/2016)... -- A new partnership announced today will help life ... a fraction of the time it takes today, ... insurance policies to consumers without requiring inconvenient and ... rapid testing (A1C, Cotinine and HIV) and higi,s ... pulse, BMI, and activity data) available at local ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" ... by its major shareholders, Clean Technology Fund I, LP ... States based venture capital funds which together ... (on a fully diluted, as converted basis), that they ... their entire equity holdings in Biorem to TUS Holdings ...
(Date:6/27/2016)... ... 2016 , ... Newly created 4Sight Medical Solutions ... healthcare market. The company's primary focus is on new product introductions, to include ... are necessary to help companies efficiently bring their products to market. , The ...
(Date:6/24/2016)...  Regular discussions on a range of subjects including policies, ... entities said Poloz. Speaking at a lecture to ... he pointed to the country,s inflation target, which is set ... "In certain areas there needs ... economic goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... the release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” ... and retention in this eBook by providing practical tips, tools, and strategies for ...
Breaking Biology Technology: