Navigation Links
WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
Date:3/22/2011

DETROIT Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited. A Wayne State University researcher, however, is expanding the scientific understanding of what makes malignant tumors spread, and the answer lies within the dense, fibrous matrix that surrounds cancer cells.

Karen A. Beningo, Ph.D., assistant professor of biology in WSU's College of Liberal Arts and Sciences and resident of Plymouth, Mich., has found that the continuous restructuring of the extracellular matrix that upholds the weight of a tumor is one of the reasons highly invasive, malignant tumors are mechanically able to spread to other parts of the body. Beningo's study was recently published in PLoS ONE.

"This study has identified a novel physical parameter and a new conceptual framework in which to assess the process of invasion, not just of cancer cells but other invasive cell types as well," said Beningo.

Beningo simulated the tugging and pulling forces by embedding magnetic microbeads in the collagen matrix of a three-dimensional, cell-based assay. This way, she was able to examine the physical mechanisms "without the complication of secreted biochemical factors," she said.

"Surprisingly, we found that cancer cells were two to four times more likely to invade if the matrix was magnetically stimulated than if the culture was not stimulated," said Beningo.

She also found that less invasive tumors were not as stimulated by the tugging and pulling forces of the extracellular matrix as highly invasive tumors. Moreover, the absence of fibronectin, a component of the extracellular matrix, and cofilin, a cellular protein, removed the tumor's sensitivity to the mechanical "come hither" stimulus.

"We can conclusively state that fibronectin and cofilin are required for thi
'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. Junk DNA proves functional
3. First at-home test for vasectomized men proves to be safe, accurate
4. Microarray analysis improves prenatal diagnosis
5. Replacing corn with perennial grasses improves carbon footprint of biofuels
6. An essay proves that vegetation could recover in the ski resort of Sierra Nevada
7. Organic plant waste proves effective weed control for citrus trees
8. Study finds rescue course of antenatal steroids improves outcome in premature babies
9. Queens University Belfast improves Malaysian public health
10. Taste, odor intervention improves cancer therapy, according to Virginia Tech, Wake Forest study
11. Photoselective film proves effective for controlling height in potted gardenia plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Johannes Gutenberg University Mainz (JGU) as a full ... to maintain a significant nationwide standing in the ... of Johannes Gutenberg University Mainz as a full ... the national and international competition for the best ... can be proud that Mainz University has been ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... growing mobile commerce market releases photos and video of the recent ... October 13 th . Gino Pereira , ... angel investor Mr. Chad A. Verdi rang the bell.  ... his investors and employees "for their work and dedication in bringing ...
(Date:10/14/2014)... N.C. – Like discriminating thieves, prostate cancer tumors scavenge ... the body. But such avarice may be a fatal ... a way to kill prostate cancer cells by delivering ... selectively destroys the diseased cells brimming with the mineral, ... uses two drugs already commercially available for other uses, ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Prostate cancer's penchant for copper may be a fatal flaw 2
... Diego, CA (March 18, 2009) Epidemiologists and computer ... create a new low-cost, green technology for automatically tracking ... enter and after they exit patient rooms. This ... essential for infection control in hospitals, was released today ...
... choose their mates based on fancy feathers. Female mammals, ... follow their noses to the right mate. That,s one ... Katherine McAuliffe, whose review of evidence for female mate ... The Quarterly Review of Biology . Historically, ...
... Cliff I. Davidson, Joseph B. Kadane and Nanjun Chu ... East End areas of Pittsburgh are more affected by ... Because more than three-quarters of particulate matter found in ... mainly to the west the importance of ...
Cached Biology News:Pilot study shows effectiveness of new, low-cost method for monitoring hand hygiene compliance 2Female mammals follow their noses to the right mates 2Carnegie Mellon researchers apply new statistical test 2
(Date:10/19/2014)... 19, 2014 The Latin American hardware ... in Latin America with analysis and forecast of revenue. ... and is expected to reach $2,366.8 million by 2018, ... , Browse through the TOC of the Latin American ... the in-depth analysis provided. It also provides a glimpse ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla ... Forecast (2011 - 2016)," analyzes the chocolate market ... major market drivers, restraints, and opportunities for the chocolate ... global chocolate market is expected to grow from $83.2 ... estimated CAGR of 2.7% from 2011 to 2016. , ...
(Date:10/19/2014)... According to market research report “Outdoor Wi-Fi Market ... Global Advancements, Forecasts and Analysis (2013 - 2018)", ... with analysis and forecasting of the global revenues. ... and the restrains for this market with the ... Browse 65 market data tables and 69 figures ...
Breaking Biology Technology:The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... N.J., Sept. 21 Nuvilex, Inc. (OTC Bulletin Board: NVLX), ... with Reme-Flu(TM), will be incorporating Syn-X9(TM) proprietary delivery technology into ... to help prevent and treat flu-type symptoms resulting from influenza-like ... , , The unique attributes of the ...
... , ATLANTA, Sept. 21 CryoLife, Inc. (NYSE: ... to suburban Atlanta this week for the two-day Ross Summit ... of the Ross Procedure and to practice the technical nuances required to perform ... The Ross Procedure is a type of specialized aortic valve surgery in ...
... Mass., Sept. 21 Merrimack Pharmaceuticals, Inc., announced today that ... President, Development. Dr. Niyikiza comes to Merrimack from GlaxoSmithKline (GSK) ... oncology. Dr. Niyikiza has extensive drug development experience with ... pharmaceutical industry in which he has led ten New Drug ...
Cached Biology Technology:Nuvilex, Inc. Announced that Reme-Flu(TM) will Incorporate Proprietary Syn-X9(TM) Delivery Technology into its Product Formulation 2Nuvilex, Inc. Announced that Reme-Flu(TM) will Incorporate Proprietary Syn-X9(TM) Delivery Technology into its Product Formulation 3Leading Cardiovascular Surgeons Gather from Around the World to Share Ross Procedure Survival Data, Techniques at 2nd Annual Summit 2Leading Cardiovascular Surgeons Gather from Around the World to Share Ross Procedure Survival Data, Techniques at 2nd Annual Summit 3Leading Cardiovascular Surgeons Gather from Around the World to Share Ross Procedure Survival Data, Techniques at 2nd Annual Summit 4Leading Cardiovascular Surgeons Gather from Around the World to Share Ross Procedure Survival Data, Techniques at 2nd Annual Summit 5Merrimack Pharmaceuticals Names Clet Niyikiza, Ph.D. Senior Vice President, Development 2
SDS-OutT SDS Precipitation Reagent...
... tray. Ideal for staining westerns and includes ... multipurposes. Pour spouts in each corner facilitate ... may be used for identification. Lid is ... shakers for staining several gels simultaneously. Lid ...
... are disposable microfiltration devices for the fast and ... 100 l to 500 l. They can be ... centrifuge tubes. Product Features: High-flux Polyethersulphonemembrane ... Low hold up volume ( Fast and reproducible ...
... a novel disposable spin filtration device especially ... lysates in plasmid purification procedures. , ... spin filtration device especially designed to aid ... purification procedures. The neutralized lysate is centrifuged ...
Biology Products: