Navigation Links
WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
Date:3/22/2011

DETROIT Ninety percent of cancer deaths resulted from metastasis, the spread of cancer to different areas in the body, yet scientific exploration of the possible mechanical factors that promote metastasis has been limited. A Wayne State University researcher, however, is expanding the scientific understanding of what makes malignant tumors spread, and the answer lies within the dense, fibrous matrix that surrounds cancer cells.

Karen A. Beningo, Ph.D., assistant professor of biology in WSU's College of Liberal Arts and Sciences and resident of Plymouth, Mich., has found that the continuous restructuring of the extracellular matrix that upholds the weight of a tumor is one of the reasons highly invasive, malignant tumors are mechanically able to spread to other parts of the body. Beningo's study was recently published in PLoS ONE.

"This study has identified a novel physical parameter and a new conceptual framework in which to assess the process of invasion, not just of cancer cells but other invasive cell types as well," said Beningo.

Beningo simulated the tugging and pulling forces by embedding magnetic microbeads in the collagen matrix of a three-dimensional, cell-based assay. This way, she was able to examine the physical mechanisms "without the complication of secreted biochemical factors," she said.

"Surprisingly, we found that cancer cells were two to four times more likely to invade if the matrix was magnetically stimulated than if the culture was not stimulated," said Beningo.

She also found that less invasive tumors were not as stimulated by the tugging and pulling forces of the extracellular matrix as highly invasive tumors. Moreover, the absence of fibronectin, a component of the extracellular matrix, and cofilin, a cellular protein, removed the tumor's sensitivity to the mechanical "come hither" stimulus.

"We can conclusively state that fibronectin and cofilin are required for this mechanical response," said Beningo.

Beningo is working toward defining the mechanism of mechanically enhanced invasion and hopes to identify therapeutic targets.

"If we can prevent the invasive movement of cancer cells from the primary tumor, a large battle in the war on cancer will have been won," she said.

Financial support for the study was provided by Wayne State University.


'/>"/>

Contact: Julie O'Connor
julie.oconnor@wayne.edu
313-577-8845
Wayne State University - Office of the Vice President for Research
Source:Eurekalert

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. Junk DNA proves functional
3. First at-home test for vasectomized men proves to be safe, accurate
4. Microarray analysis improves prenatal diagnosis
5. Replacing corn with perennial grasses improves carbon footprint of biofuels
6. An essay proves that vegetation could recover in the ski resort of Sierra Nevada
7. Organic plant waste proves effective weed control for citrus trees
8. Study finds rescue course of antenatal steroids improves outcome in premature babies
9. Queens University Belfast improves Malaysian public health
10. Taste, odor intervention improves cancer therapy, according to Virginia Tech, Wake Forest study
11. Photoselective film proves effective for controlling height in potted gardenia plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
(Date:11/22/2016)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that the company has ... Sciences Awards as "Most Outstanding in eClinical Solutions" ... of recognition and growth for MedNet, which has effectively ... iMedNet ™ , MedNet,s flagship eClinical ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... ProMIS ... of precision treatments for neurodegenerative diseases, today announced the validated monoclonal antibody ... direct neurotoxic effect of prion-like forms of Amyloid beta (Aß) in vitro. ...
(Date:12/5/2016)... Dec. 5, 2016 Axovant Sciences Ltd. (NYSE: ... focused on the treatment of dementia, today announced that ... treatment of Alzheimer,s disease will be presented at the ... Friday, December 9, 2016 in San Diego ... of both simple and complex measures of activities of ...
(Date:12/5/2016)... -- Research and Markets has announced the addition ... Companies" to their offering. ... , , This report ... technologies such as proteomics and metabolomics. Molecular diagnostics technologies are used ... on biomarker. Currently the most important applications of biomarkers ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... resume cervical and lumbar disc production, company President, Jake Lubinski will be traveling ... implanting the AxioMed disc in Cologne and Karlsruhe to discuss the benefits of ...
Breaking Biology Technology: