Navigation Links
WPI wins NIH grant to study components of a potentially potent, low-cost malaria treatment
Date:7/15/2014

ion.

In previous work Weathers and her colleagues have shown that mice fed powered dried leaves had 40 times more artemisinin in their blood stream than mice fed pure artemisinin. Furthermore, the whole-plant therapy was five times more effective in clearing the disease-causing parasite from the mice. In addition to delivering more artemisinin to the bloodstream, the effectiveness of the whole plant treatment may be due to the presence of other potentially therapeutic compounds in the leaves.

In the new study, Weathers will use a laboratory model of the human digestive system to discover which compounds in the leaves move through the intestinal wall. She will focus on several compounds, including flavonoids and terpenes, which have exhibited antimalarial effects of their own and which may also help artemisinin move through the intestinal wall and into the bloodstream where it can attack the malaria parasite.

Flavonoids are widely distributed in plants and have various functions, including giving blossoms color. They are also believed to work synergistically with artemisinin to kill the malaria parasite. Terpenes are among the essential oils that play a role in the plant's defense system. Secreted terpenes have anti-microbial properties and deter some leaf-eating predators.

In a series of experiments over the next three years, the Weathers lab will use a cell culture model to study how the flavonoids and terpenes move through a layer of cultured human intestinal wall cells. They will also test the flavonoids and terpenes in combination with artemisinin to see how they affect the movement of artemisinin across the cell layer.

"Because these other compounds in the plant have some therapeutic activity, using the whole plant becomes an effective plant-based combination therapy," Weathers said. "Through this study, we hope to develop a better understanding of what compounds in the plant may be involved in making artemisinin mor
'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A fragrant new biofuel
2. Record-breaking grant: New research project to investigate the causes of mental disorders
3. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
4. ASBMB wins National Science Foundation grant to enhance K-12 science education
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Kinesiology team gets $975,000 Defense grant to study effects of heavy loads on soldiers
7. Michael J. Fox Foundation grant to Dr. Samuel Young will provide Parkinsons drug development tools
8. UC Riverside receives grant for global health and development research
9. Biology professor secures grant to save West Virginias primary natural history collection
10. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
11. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
WPI wins NIH grant to study components of a potentially potent, low-cost malaria treatment
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
Breaking Biology News(10 mins):AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... Few events involving animals are more dramatic than when ... cross-country. Among examples are the many thousands of wildebeests ... across the African plains. , Countless millions of ... with their own kind and form teeming, hungry islands ...
... components of our blood, are ancient proteins with well-known ... are also present in plants and bacteria, but until ... unclear. A group of researchers reveal this week that ... the fixation of nitrogen in the root nodules of ...
... Scientists at the U.S. Department of Energy's Brookhaven National ... in medical imaging to track the distribution of nutrients ... attack. The research provides new insights on a long-debated ... shows that radiotracer imaging can be a big help ...
Cached Biology News:Experiments provide proof of how traveling in groups protects insects 2Plant hemoglobins: Oxygen handlers critical for nitrogen fixation 2Poplar trees redirect resources in response to simulated attack 2Poplar trees redirect resources in response to simulated attack 3
(Date:8/26/2015)... , Aug. 26, 2015 Intrexon Corporation ... announced today the closing of its previously announced public ... by the underwriters of their option to purchase an ... offering price of $41.00 per share.  The exercise of ... of common stock sold by Intrexon to 5,609,756 shares ...
(Date:8/26/2015)... HONG KONG , Aug. 26, 2015 ... "Company"), China,s leading provider of ... and stem cell storage services, today announced that the ... Holdings Limited ("MO2"), an entity wholly owned by Mr. ... the Company, has acquired the outstanding shares (the "Shares") ...
(Date:8/26/2015)... , August 26, 2015 ... factors fueling the optimism in biotech,s forecast is ... and life sciences advancements.  Active biotechnology & healthcare ... BioSciences, Inc. (OTCQB: PBIO), Sequenom, Inc. (NASDAQ: ... ), Raptor Pharmaceutical Corp. (NASDAQ: RPTP ) ...
(Date:8/26/2015)... MA (PRWEB) , ... August 26, 2015 , ... The ... for Boston adult stem cell technology start-up company Asymmetrex to share the ... the capabilities of a new biomarker for counting adult tissue stem cells. , With ...
Breaking Biology Technology:Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 2New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 3New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 4New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 5New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 6New Collaborations & Mergers For Research of Molecular Biomarkers in Human Diseases & Clinical Trials for Cancer Therapies Fueling Growth in Multi-Billion Dollar Life Sciences Market 7Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... , AMES, Iowa, July 20 ... in a Series D financing to accelerate the clinical development of ... prior investors. , , "NewLink has ... field of cancer immunotherapy," said Dr. Charles Link, Chairman and Chief ...
... , , INDIANAPOLIS and ST. ... closer to realizing the greater whole farm corn yield advantages of ... comprehensive insect and weed control and allow farmers to significantly reduce ... which is the outcome of a cross licensing agreement and research ...
... , , NEWPORT, R.I., ... improving patient-driven self-care, announced today that it will partner ... to the healthcare industry, to develop an innovative new ... and information they need to better manage their health. ...
Cached Biology Technology:Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 2Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 3Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 4Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 5Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 6Dow AgroSciences, Monsanto Complete U.S. and Canadian Regulatory Authorizations for SmartStax Corn; Plans Set to Launch Seed Platform on 3 Million- to 4 Million-Plus Acres 7iSource Networks Partners with inVentiv Health to Develop New Technology Platform for Reaching Healthcare Consumers 2iSource Networks Partners with inVentiv Health to Develop New Technology Platform for Reaching Healthcare Consumers 3