Navigation Links
WPI wins NIH grant to study components of a potentially potent, low-cost malaria treatment
Date:7/15/2014

WORCESTER, Mass. With a three-year, $420,000 award from the National Institutes of Health (NIH), a team of researchers at Worcester Polytechnic Institute (WPI) will test a plant-based therapy it is developing that may prove to be a highly effective and low-cost treatment for malaria, one of the world's most prevalent and deadly infectious diseases.

According to the World Health Organization, more than 200 million people contracted malaria in 2012 and some 627,000mostly children under the age of 5died from the disease. Caused by a mosquito-borne parasite, the illness is reported in nearly 100 countries and threatens nearly half of the world's population.

Led by Pamela Weathers, PhD, professor of biology and biotechnology, the WPI team is testing a therapy that consists of dried leaves from the sweet wormwood plant, Artemisia annua. The plant produces a compound called artemisinin, which in combination with other antimalarial drugs is the primary treatment for malaria today.

Unfortunately, artemisinin combination therapy (ACT) is expensive to produce and is often in short supply in areas hit hardest by the disease. In addition, while the combination therapy is designed to be less prone to the drug resistance that has rendered previous antimalarial agents ineffective, the malaria parasite is beginning to show signs of resistance to ACT, particularly in Southeast Asia. "Malaria remains a major global health crisis and the increasing drug resistance is alarming," Weathers said. "Our ultimate goal is to make an easy-to-produce therapy available to the people who need it most."

Artemisia annua has been used as an herbal therapy for thousands of years, typically as a tea infusion to treat fever. Today, artemisinin, the principal therapeutic compound in the plant, is extracted, purified, and combined with other drugs to make ACT. Weathers's team takes a different approach, using dried whole leaves from Artemisia annua as a medicat
'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. A fragrant new biofuel
2. Record-breaking grant: New research project to investigate the causes of mental disorders
3. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
4. ASBMB wins National Science Foundation grant to enhance K-12 science education
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Kinesiology team gets $975,000 Defense grant to study effects of heavy loads on soldiers
7. Michael J. Fox Foundation grant to Dr. Samuel Young will provide Parkinsons drug development tools
8. UC Riverside receives grant for global health and development research
9. Biology professor secures grant to save West Virginias primary natural history collection
10. Lawson recieves Grand Challenges Explorations grant for groundbreaking research
11. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
WPI wins NIH grant to study components of a potentially potent, low-cost malaria treatment
(Date:12/10/2014)... WINSTON-SALEM, N.C. , Dec. 9, 2014  Wake Forest ... medical education building for its School of Medicine. Funding ... a larger capital campaign that will be publicly launched ... will be located in the former 60 series R.J. ... Forest Innovation Quarter. Construction will begin immediately with plans ...
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2
... a simultaneous publication (Science Express, 13th April 2006), ... bruchpilot protein and aided neurobiologists from the European ... the protein's central role in the formation of ... from conventional farfield light microscopy in the fact ...
... processes are affecting southern right whales (Eubalaena australis) in ... team of scientists found a strong relationship between breeding ... Nino in the western Pacific. The results are published ... Southern right whales migrate from the South Atlantic to ...
... researchers for many years has been explained by UK scientists. ... of carbon in the Earth's atmosphere require vitamin B12 to ... why some types needed external sources and others did not. ... discovered that half of all algae have a dependent but ...
Cached Biology News:High-resolution light microscope reveals the fundamental mechanisms of nerve communication 2High-resolution light microscope reveals the fundamental mechanisms of nerve communication 3The secret life of algae 2
(Date:12/24/2014)... MA (PRWEB) December 23, 2014 ... webinar series is designed to introduce cutting ... inform users and partners of platform upgrades. ... and benefits; empowering users in their quest ... powerful tools. , According to SoundConnect’s Marketing ...
(Date:12/24/2014)... Texas (PRWEB) December 23, 2014 ... methyl mercaptan such as its definition, classification, ... presents product specification, manufacturing process, and product ... technology and applications. The analysis also covers ... marketing channels, industry development trend and proposals. ...
(Date:12/24/2014)... San Diego, CA (PRWEB) December 23, 2014 ... Contest where their Twitter followers can submit their ... for themselves and their lab mates. , For those ... beloved lab mates, the Pipette.com Holiday in the Lab ... encourages Pipette.com Twitter followers to send pictures ...
(Date:12/24/2014)... , December 23, 2014 PharmaBoardroom,s ... , out today and available for free download , ... driving change and growth in the sector today. ... notable successes has been in developing a homegrown pharmaceutical manufacturing ... local production still remains some way off. A cursory comparison ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3
... For purification of microRNA and total RNA from a wide range of animal tissues and cells ... miRNeasy Kits allow purification of total RNA including miRNA or enrichment , ... for , low-throughput RNA purification. The miRNeasy 96 Kit ... , ...
... , ... the global leader in capital asset auction and ... conducting its 50th global Life Sciences / BioPharma , ... for the DoveBid.com Life Sciences / BioPharma practice, and ...
... For low-throughput disruption of a wide range of biological samples , ... , , The ... tissues and cells and plant tissue. , , ... , Disposable probes to help eliminate cross-contamination ...
Cached Biology Technology:miRNeasy Mini Kit and miRNeasy 96 Kit 2miRNeasy Mini Kit and miRNeasy 96 Kit 3World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition 2World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition 3TissueRuptor System 2TissueRuptor System 3
... selects single cells, or clusters, with rapid, ... all, a single cell can be targeted, ... collected into the pipette, and automatically transferred ... plate. Quixells unique aspiration and expulsion system ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Viruses microRNA Microarray contains ...
... At the forefront of Agilent analytical ... Built-in local area networking (LAN) allows you ... sites--for fast and informed decision making. Just ... has all the flexibility and performance needed ...
The novel and unique HCTplus delivers unmatched information-rich data-dependent LC/MSn data for todays challenge in proteomics and metabonomics work....
Biology Products: