Navigation Links
WPI team scales-up production of biopolymer microthreads
Date:4/30/2012

ng commissioned. Computer-controlled, the new system is capable of continuous extrusion with a range of specified thread diameters and quantities.

"I think this project shows the importance of bringing together multidisciplinary teams, focused on the biology and the engineering, to create solutions that will meet real clinical needs," Gaudette said.

The Pins lab continues to develop the microthread technology for use as potential ligament and tendon scaffolds while also working to optimize the composition and mechanical properties of the threads. For example, they are experimenting with ways to control the tensile strength of the threads, and to control the rate at which the threads dissolve once implanted in the body. They have also developed new technologies to tailor the surface topographies and biochemistries of the microthreads to provide specific signaling cues that they predict will direct cell-mediated tissue responses.

In Gaudette's lab, the threads are being used as biological sutures to deliver bone marrowderived adult stem cells known as human mesenchymal stem cells (hMSCs) to cardiac tissue damaged by disease or trauma. Studies by Gaudette and others have shown that when hMSCs are delivered to damaged hearts, they moderately improve cardiac function. A major challenge in these studies, however, is getting sufficient numbers of hMSCs to engraft into the damaged heart tissue. Prior methods of injecting the cells into the bloodstream, or directly into the heart muscle, yielded low results, with 15 percent or fewer of the cells injected actually surviving and attaching to the heart muscle. Using the microthreads to deliver cells to the heart has changed that dynamic.

"The early studies are very promising," Gaudette said. "We have developed ways to seed and grow the stem cells on the microthreads, and deliver them directly to the area needed, with more than 60 percent of those cells successfully engrafting. That's a major
'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. Mandate for biofuels production requires science-based policy and global perspective
3. Oklahoma researchers support biodiversity in biofuels production
4. New $11 million center to speed production of new compounds for drug discovery
5. Biosynthetics production with detours
6. Bacteria manage perfume oil production from grass
7. New hybrid plants could prompt more prodigious pepper production in Southwest
8. Scripps research scientists identify compounds for stem-cell production from adult cells
9. December 2008 highlights from Biology of Reproduction
10. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
11. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
WPI team scales-up production of biopolymer microthreads
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/21/2014)... VIEW, Calif. , Nov. 20, 2014 ... higher driver efficiency are piloting the North American and ... number of accidents growing, gesture recognition systems that are ... make a mark in the industry. ... the Automotive Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Ministry of Education and Research (BMBF) will fund the ... II) by German and international researchers to the tune ... The Helmholtz Research Centers Juelich, Berlin, and Geesthacht are ... The basis for these grants is the cooperation between ...
... 2010 Scientists from the Florida campus of The ... infectious protein that can cause fatal neurodegenerative disease such ... have the ability to adapt to survive in a ... lack DNA and RNA, they behave much like viruses, ...
... beetroot juice suggests it,s not only athletes who can benefit ... help the elderly or people with heart or lung-conditions enjoy ... the biggest stories in sports science over the past year ... people to exercise for up to 16% longer. The startling ...
Cached Biology News:German federal government bolsters neutron research in Garching 2German federal government bolsters neutron research in Garching 3Scripps Research scientists show prions mutate and adapt to host environment 2Scripps Research scientists show prions mutate and adapt to host environment 3Beetroot juice could help people live more active lives 2
(Date:12/17/2014)... December 17, 2014 Xeno Diagnostics ... following its most recent COLA inspection. Xeno has ... a national healthcare accreditation organization. Accreditation is earned ... quality in day-to-day operations, demonstrate continued accuracy in ... rigorous on-site laboratory survey. , While ...
(Date:12/17/2014)... Audacity, a leading California-based health and ... the Huntsworth Health Group, is proud to announce the ... her role, Gonzales will serve as Senior Vice President ... to welcome a talent of Jamie’s caliber to the ... “She is a proven healthcare innovation leader and brand ...
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
Breaking Biology Technology:Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4
... September 27, 2011 Circassia Ltd, ... announced positive phase II clinical results showing that ... allergy symptoms compared with those on placebo.  The ... During the randomised, double-blind, placebo-controlled phase II study ...
... Researchers of the Chemical Engineering department and the Kavli ... have demonstrated that electrons can move freely in layers ... This new knowledge will be very useful for the ... The researchers published their findings on Sunday 25 September ...
... ( www.ucr.edu ) -- Two professors from the University ... $1.5 million to study a new approach that could ... and increase speed in the next generation of computers. ... chair of the materials science and engineering program, and ...
Cached Biology Technology:Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 2Circassia's Hay Fever Treatment Improves Patients' Allergy Symptoms in Phase II Clinical Trial 3TU Delft: cheap and efficient solar cell made possible by linked nanoparticles 2Bold approach could change electronics industry 2Bold approach could change electronics industry 3
... Reduce bench time to just 15 minutes! ... the paralles that can be drawn between this ... idea of instant foods. Instant meals consumed ... freeze-dried format and are reconstituted by adding water. ...
APO(a) EIA Sample Size: 25 l...
...
Request Info...
Biology Products: