Navigation Links
WPI team scales-up production of biopolymer microthreads
Date:4/30/2012

ng commissioned. Computer-controlled, the new system is capable of continuous extrusion with a range of specified thread diameters and quantities.

"I think this project shows the importance of bringing together multidisciplinary teams, focused on the biology and the engineering, to create solutions that will meet real clinical needs," Gaudette said.

The Pins lab continues to develop the microthread technology for use as potential ligament and tendon scaffolds while also working to optimize the composition and mechanical properties of the threads. For example, they are experimenting with ways to control the tensile strength of the threads, and to control the rate at which the threads dissolve once implanted in the body. They have also developed new technologies to tailor the surface topographies and biochemistries of the microthreads to provide specific signaling cues that they predict will direct cell-mediated tissue responses.

In Gaudette's lab, the threads are being used as biological sutures to deliver bone marrowderived adult stem cells known as human mesenchymal stem cells (hMSCs) to cardiac tissue damaged by disease or trauma. Studies by Gaudette and others have shown that when hMSCs are delivered to damaged hearts, they moderately improve cardiac function. A major challenge in these studies, however, is getting sufficient numbers of hMSCs to engraft into the damaged heart tissue. Prior methods of injecting the cells into the bloodstream, or directly into the heart muscle, yielded low results, with 15 percent or fewer of the cells injected actually surviving and attaching to the heart muscle. Using the microthreads to deliver cells to the heart has changed that dynamic.

"The early studies are very promising," Gaudette said. "We have developed ways to seed and grow the stem cells on the microthreads, and deliver them directly to the area needed, with more than 60 percent of those cells successfully engrafting. That's a major
'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. Mandate for biofuels production requires science-based policy and global perspective
3. Oklahoma researchers support biodiversity in biofuels production
4. New $11 million center to speed production of new compounds for drug discovery
5. Biosynthetics production with detours
6. Bacteria manage perfume oil production from grass
7. New hybrid plants could prompt more prodigious pepper production in Southwest
8. Scripps research scientists identify compounds for stem-cell production from adult cells
9. December 2008 highlights from Biology of Reproduction
10. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
11. Attitudes towards assisted reproduction and preimplantation genetic diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
WPI team scales-up production of biopolymer microthreads
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/8/2015)... NEW YORK , July 8, 2015  BD ... announced BD & Guidepoint Mentor, a new ... to Guidepoint,s expert network services. BD ... technologies to improve healthcare delivery and outcomes and, with ... start-up entrepreneur will be able to directly engage with ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... (NIST), in collaboration with the Centers for Disease Control ... Materials (SRMs) for measurements of human exposure to environmental ... check the accuracy of tests and analytic procedures, the ... measures for emerging environmental contaminants such as perchlorate, a ...
... outside Seville, in the desert region of Andalucia, Spain, sits ... giant mirrors rippling outward. More than 600 of these mirrors, ... sun throughout the day, concentrating its rays on the central ... enough to power 6,000 homes. The sprawling site, ...
... different immunological mechanisms ensure the successful establishment and maintenance ... adverse pregnancy outcomes. In a review published in ... Institute of Life Science, College of Medicine at Swansea ... obesity on the inflammatory responses in tissues of both ...
Cached Biology News:NIST releases 2 new SRMs for monitoring human exposure to environmental toxins 2MIT research: A new sunflower-inspired pattern increases concentrated solar efficiency 2MIT research: A new sunflower-inspired pattern increases concentrated solar efficiency 3Inflammation may link obesity and adverse pregnancy outcomes 2
(Date:7/31/2015)... 2015 China Cord Blood Corporation (NYSE: CO) ... leading provider of cord blood collection, laboratory testing, hematopoietic ... announced that the Company has filed its Annual Report ... Commission. The filed Form 20-F includes audited financial statements ... Form 20-F can be accessed by visiting the U.S. ...
(Date:7/30/2015)... July 30, 2015   GenoSpace , a ... interpretation and analysis of genomic and other biomedical ... has joined the company as Vice President of ... http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace partners with ... interpret, analyze and explore complex sets of genomic, ...
(Date:7/30/2015)... Diego , CA (PRWEB) , ... July 30, ... ... announced the successful completion of a field clinical study of its canine osteoarthritis ... developed together with Aratana Therapeutics (Kansas City, KS) and will be marketed in ...
(Date:7/30/2015)... , July 30, 2015 Ascendis Pharma ... that applies its innovative TransCon technology to address ... results from a six-month Phase 2 study to ... Growth Hormone in 53 treatment-naïve, pre-pubertal children with ... are extremely pleased with the top-line results from ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7
... Oct. 3 NPS Pharmaceuticals,Inc. (Nasdaq: NPSP ) ... its,cash tender offer with respect to its outstanding $171.8 ... due 2008. Under,the amended terms of the tender offer, ... of the outstanding convertible notes at a,purchase price, per ...
... RICHMOND, Calif., Oct. 3 Sangamo BioSciences,Inc. (Nasdaq: ... president of research, will provide an update on the ... of the,company,s business strategy at 12:45pm (PT) on Wednesday, ... The presentation will be webcast live and may ...
... WALTHAM, Mass., Oct. 3 Thermo Fisher,Scientific ... that it has acquired Priority,Solutions International, a ... healthcare industries, following anti-trust clearance.,Priority Solutions was ... of approximately $95 million in 2006, Priority,Solutions ...
Cached Biology Technology:NPS Pharmaceuticals, Inc. Announces an Increase in Tender Offer Price for Its 3.0% Convertible Notes Due 2008 and Extends Expiration Date Until October 17, 2007 2NPS Pharmaceuticals, Inc. Announces an Increase in Tender Offer Price for Its 3.0% Convertible Notes Due 2008 and Extends Expiration Date Until October 17, 2007 3Sangamo BioSciences to Present at the 2007 BIO InvestorForum 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 2Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 3Thermo Fisher Scientific Acquires Logistics Provider to Strengthen Clinical Trials Management Services 4
... Linkage: This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Mouse C2C12 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
... (PI) is a fluorescent nucleic acid dye ... As a nuclear counterstain, propidium iodide ... in color. The fluorescent red color ... fluorochromes such as FITC, Cy2 or AMCA. ...
... parameter assay for mitochondrial membrane potential ... caspases are detected by carboxyfluorescein (FAM)-labelled ... cell-permeable, non-cytotoxic and bind covalently to ... At the same time the mitochondrial ...
Biology Products: