Navigation Links
Vivax malaria may be evolving around natural defense
Date:11/15/2013

2008 sequencing of P. vivax, which is used as a reference genome, suggesting the developments are recent.

"Binding proteins and receptors are locks and keys," Zimmerman said. "If the parasite has one key and there's one lock, you may be able to block that. But if it has more keys and there are more locks, there are multiple ways in."

The researchers say the duplication may be a cause of the growing infections among Duffy negative people, but it's too early to tell.

Zimmerman, Serre and colleagues aim to find the answer with the newly-funded research project. They'll begin by studying blood samples taken from 1,500 patients at each of two locations in Madagascar.

They and colleagues have great concern that a loss of resistance to P. vivax infection will now enable the parasite to travel the 250 miles across the Mozambique Channel to Africa. There, falciparum malaria is wrecking havoc on a population that has for the most part lived P. vivax-free. In some regions of the continent, 100 percent of the population is Duffy negative.

The researchers will conduct similar studies on P. vivax carrying the new proteins, in samples taken from Asia, Africa and South America.

In addition to studying patients, they plan to study the mutated parasites in the lab. Parasites that live a day or two could have enough time to invade new blood cells, but not many. Brian Grimburg, assistant professor of international health at the Case Western Reserve School of Medicine, is developing a scanning process that will enable the team to look through millions of red blood cells in a few minutes and spot newly infected cells. They will test the parasites in Duffy negative and Duffy positive red cells.

Zimmerman and Serre believe the work could help lead to a vaccinethat's the overall goal. The mechanisms P. vivax uses to attach and enter a cell could be targets.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Low-dose treatment may block malaria transmission
2. New malaria vaccines roadmap targets next generation products by 2030
3. Holograms offer hope in fight against malaria, study suggests
4. CWRU grants Disease Diagnostic Group option on malaria diagnostic device
5. NIH fellowship helps researcher fight malaria, understand mosquito immunity
6. Hand-held device cheaply, quickly diagnosis malaria
7. Quest for edible malarial vaccine leads to other potential medical uses for algae
8. Early warning system provides 4-month forecast of malaria epidemics in northwest India
9. New method for researching understudied malaria-spreading mosquitoes
10. New approach alters malaria maps
11. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vivax malaria may be evolving around natural defense
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
(Date:4/17/2014)... in bone marrow need to produce hydrogen sulfide in ... to a new study from the Center for Craniofacial ... of USC. , Professor Songtao Shi, principal investigator on ... by the cells governs the flow of calcium ions. ... that results in osteogenesis, or the creation of new ...
(Date:4/17/2014)... parasites and pathogens that devastate honeybees in Europe, Asia ... but do not appear to be impacting native honeybee ... of researchers., The invasive pests include including Nosema ... African honeybees appear to be resilient to these invasive ... to control pests in Europe, Asia and the United ...
Breaking Biology News(10 mins):Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... New Mexico, July 20, 2011Researchers at the U.S. Department ... Bioenergy Research Center have found a potential key for ... as corn leaves and stalks, or switch grass. ... the American Chemical Society , Los Alamos researchers S. ...
... another major step in sleuthing the 2010 Deepwater Horizon oil ... Institution (WHOI) determined what chemicals were contained in a deep, ... long. The scientists mapped and sampled it last summer ... the Deepwater Horizon oil spill. The researchers took a ...
... The Bureau of Reclamation and Fluid Imaging Technologies ... to improve the capacity and speed of Fluid Imaging ... zebra mussel larvae in water samples. The spread ... potential to impair or interrupt water delivery and hydropower ...
Cached Biology News:Researchers find potential key for unlocking biomass energy 2Chemical make-up of Gulf of Mexico plume determined 2Chemical make-up of Gulf of Mexico plume determined 3Chemical make-up of Gulf of Mexico plume determined 4Reclamation signs research agreement to improve quagga and zebra mussel larvae detection 2
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... The 2012 federal budget recommends the allocation of ... federal interagency research and development program that studies the ... nanoscale—a measurement of particles between 1 and 100 nanometers ... materials are found in nature as part of smoke, ...
... Metabolex, Inc., a biopharmaceutical company focused on the ... treatment of metabolic diseases, announced today that it has ... its product candidate for the management of hyperuricemia in ... study will evaluate the safety and urate-lowering activity of ...
... Ontario Institute for Cancer Research (OICR) today announced ... bringing promising anticancer technologies to market. ... bring commercial and operational leadership that will accelerate ... assets," said Frank Stonebanks, Vice-President, Commercialization and Chief ...
Cached Biology Technology:Environmental Training Center Prepares Companies to Handle Nanotechnology Environmental and Human Safety Impacts 2Metabolex Initiates Phase 2 Trial of Arhalofenate 2Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies 2Ontario Institute for Cancer Research Announces Spin Off Companies Developing Promising Anticancer Technologies 3
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... Staccato Mini-Workstations provide fast and ... genomics, proteomics and drug development laboratories. ... of instrumentation to automate basic liquid ... Mini-Workstations are controlled with either Caliper's ...
Experion StdSens chips are the microfluidic chips used to perform standard-sensitivity RNA analysis (nanogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to...
... submicron range are part of your production ... of particle size is important to you. ... detect the component populations in your sample ... Analyzer uses Photon Correlation Spectroscopy (PCS) , ...
Biology Products: