Navigation Links
Vivax malaria may be evolving around natural defense
Date:11/15/2013

CLEVELANDResearchers at Case Western Reserve University and Cleveland Clinic Lerner Research Institute have discovered recent genetic mutations in a parasite that causes over 100 million cases of malaria annuallychanges that may render tens of millions of Africans who had been considered resistant, susceptible to infection.

Peter A. Zimmerman, professor of international health, biology and genetics at the Case Western Reserve School of Medicine, and David Serre, a scientific staff member of the Genomic Medicine Institute at Lerner and assistant professor of genomics at Case Western Reserve, report their findings at the American Society of Tropical Medicine and Hygiene annual meeting today (11/15).

They and fellow researchers describe the changes in the Plasmodium vivax genome in papers scheduled to be published in the journal PLoS Neglected Tropical Disease on Nov. 21 and Dec. 5.

To learn the functions of the mutations, and whether the parasite is evolving around a natural defense, Zimmerman and Serre have received a $3.5 million grant from the National Institute of Allergy and Infectious Disease at the National Institutes of Health. They will begin their field study in early 2014.

"We've found a duplication of a gene known to enable the parasite to infect red blood cells and two possible additional components to a more complex red cell invasion mechanism," Zimmerman said

Researchers have long thought that P. vivax infects a person one way: a protein on the parasite, called the Duffy binding protein, latches onto a Duffy receptor on the surface of the person's red blood cell and works itself through the membrane. People who lack the receptor are called Duffy negative and are resistant to infection.

But, during the last decade, reports of cases of Duffy negative patients with P. vivax infections have been on the rise in several parts of the world.

P. vivax has b
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Low-dose treatment may block malaria transmission
2. New malaria vaccines roadmap targets next generation products by 2030
3. Holograms offer hope in fight against malaria, study suggests
4. CWRU grants Disease Diagnostic Group option on malaria diagnostic device
5. NIH fellowship helps researcher fight malaria, understand mosquito immunity
6. Hand-held device cheaply, quickly diagnosis malaria
7. Quest for edible malarial vaccine leads to other potential medical uses for algae
8. Early warning system provides 4-month forecast of malaria epidemics in northwest India
9. New method for researching understudied malaria-spreading mosquitoes
10. New approach alters malaria maps
11. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vivax malaria may be evolving around natural defense
(Date:12/10/2014)... 9, 2014 CIE San Diego has launched ... the connective tissue that enhances care coordination among social ... share client-level information; earned a second $1 million grant ... serving seniors aging in community and; will be recognized ... 11 th 4-6p. CIE San Diego ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... the sixth most common type of cancer and is on ... any known risk factors. Now, researchers at Fox Chase Cancer ... cells in the mouth and thus promote the spread of ... results, published in the January issue of Cancer Prevention ...
... (Mon., Jan. 3, 2011) -- New technologies and ... organogenesis. Organogenesis, essentially the process through which a ... connections to biological processes at the cellular and developmental ... treatments through tissue engineering approaches. The January issue ...
... An international team of researchers led by Daniel ... Institute for Translational Medicine and Therapeutics, has received ... Leducq to study the molecular genetics of atherosclerotic ... Novel Genes Associated with Plasma Lipids and Cardiovascular ...
Cached Biology News:Estrogen may help precancerous cells spread in oral cavity 2Transcriptome analysis, organ culture methods featured in Cold Spring Harbor Protocols 2Penn Medicine researcher receives $6 million grant for cardiovascular disease study 2
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 /PRNewswire/ ... company advancing patient care in critical areas, announced the ... of common stock, and warrants to purchase up to ... offering price of $4.00 per share and $.01 per ... of $5.00, are exercisable immediately, and expire 5 years ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ... forecasts of the revenue and share analysis. ...
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... ... Abstracts Service (CAS), the global expert on chemical information, reports that China,s ... in chemistry. China trailed Japan,s patent office, the World Intellectual Property Organization ... than a decade, but passed the USPTO in 2005, WIPO in 2006, ...
... of a two-dimensional carbon layer in which the ... resembling a honeycomb. Carbon nanotubes are rolled-up sheets ... form graphite. Graphene boasts some very special characteristics ... conductor, and reconciles such conflicting qualities as brittleness ...
... , SEATTLE, Nov. 23 Immune Design Corp. (IDC) announced ... Executive Chairman. Dr. Carter has a successful track record ... Executive Officer at ZymoGenetics, in Seattle, WA and Chief Scientific ... http://www.newscom.com/cgi-bin/prnh/20091123/SF15228 ) , Dr. Steven Reed, IDC,s founder and ...
Cached Biology Technology:China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3Polymer with honeycomb structure 2Immune Design Corp. Announces Appointment of Dr. Bruce L.A. Carter as Executive Chairman and Director 2
... Fluoroskan Ascent FL ... fluorometric and luminometric measurement ... long list of advanced ... and Luminoskan Ascent. Fluoroskan ...
...
...
... cabinets Heraeus HERAsafe KS convince with an optimum ... new frameless slanted window does not obscure the ... window design makes it easy to work in ... a height of more than 250 mm ensures ...
Biology Products: