Navigation Links
Vivax malaria may be evolving around natural defense
Date:11/15/2013

CLEVELANDResearchers at Case Western Reserve University and Cleveland Clinic Lerner Research Institute have discovered recent genetic mutations in a parasite that causes over 100 million cases of malaria annuallychanges that may render tens of millions of Africans who had been considered resistant, susceptible to infection.

Peter A. Zimmerman, professor of international health, biology and genetics at the Case Western Reserve School of Medicine, and David Serre, a scientific staff member of the Genomic Medicine Institute at Lerner and assistant professor of genomics at Case Western Reserve, report their findings at the American Society of Tropical Medicine and Hygiene annual meeting today (11/15).

They and fellow researchers describe the changes in the Plasmodium vivax genome in papers scheduled to be published in the journal PLoS Neglected Tropical Disease on Nov. 21 and Dec. 5.

To learn the functions of the mutations, and whether the parasite is evolving around a natural defense, Zimmerman and Serre have received a $3.5 million grant from the National Institute of Allergy and Infectious Disease at the National Institutes of Health. They will begin their field study in early 2014.

"We've found a duplication of a gene known to enable the parasite to infect red blood cells and two possible additional components to a more complex red cell invasion mechanism," Zimmerman said

Researchers have long thought that P. vivax infects a person one way: a protein on the parasite, called the Duffy binding protein, latches onto a Duffy receptor on the surface of the person's red blood cell and works itself through the membrane. People who lack the receptor are called Duffy negative and are resistant to infection.

But, during the last decade, reports of cases of Duffy negative patients with P. vivax infections have been on the rise in several parts of the world.

P. vivax has b
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Low-dose treatment may block malaria transmission
2. New malaria vaccines roadmap targets next generation products by 2030
3. Holograms offer hope in fight against malaria, study suggests
4. CWRU grants Disease Diagnostic Group option on malaria diagnostic device
5. NIH fellowship helps researcher fight malaria, understand mosquito immunity
6. Hand-held device cheaply, quickly diagnosis malaria
7. Quest for edible malarial vaccine leads to other potential medical uses for algae
8. Early warning system provides 4-month forecast of malaria epidemics in northwest India
9. New method for researching understudied malaria-spreading mosquitoes
10. New approach alters malaria maps
11. Young malaria parasites refuse to take their medicine, may explain emerging drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vivax malaria may be evolving around natural defense
(Date:8/10/2015)... , August 10, 2015 The latest ... offers comprehensive analysis of the global border security market ... revenues of $16.4bn in 2015. Now: Border security ... an example of the business critical issue you need to ... visiongain ,s objective analysis of how this will impact ...
(Date:8/5/2015)... , August 5, 2015 Transparency ... "Facial Recognition Market - Global Industry Analysis, Size, Share, ... market for facial recognition is forecast to reach US$ ... increased demand for surveillance systems by civil and government ... of crimes and terrorist activities across the globe that ...
(Date:7/31/2015)... SHENZHEN , Kina, 31. juli 2015 ... ) bliver afholdt af BGI fra den 22. - 25. ... Konferencen fejrer sin 10-års fødselsdag i år. ... verdens mest indflydelsesrige årlige møder på ,omik,-feltet, og er ... forsamlinger. ICG-10 fokuserer på nylige gennembrud ...
Breaking Biology News(10 mins):Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... 2012  BioFortis Inc., a leading software company ... today introduced its Next Generation Biobanking software ... help pharmaceutical, government and academic research centers ... to safely and effectively conduct externalized, science-driven ...
... professor of chemistry at the George Washington University,s Virginia ... to continue studying methods of producing cement and other ... into the environment. , The four-year grant ... in-house expertise in geochemistry, modeling, green industry and life ...
... that thigh size in obese people is a reason their ... study, the team simulated hip dislocations as they occur in ... in morbidly obese patients (those with a body mass index ... surgical procedures to minimize the chance of dislocation in obese ...
Cached Biology News:BioFortis Inc., Introduces Next Generation Biobanking Software Platform for Biomarker-Based Clinical Research 2The George Washington University Researcher received $1.7 million to study solar cement 2Engineering a better hip implant 2Engineering a better hip implant 3
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... ... 27, 2015 , ... Inc. Magazine released its annual list of the 5,000 ... in growth for the three years through 2014. Being named to the Inc. 5000 ... in the country. , “We are thrilled to make the Inc. 5000 list ...
(Date:8/26/2015)... ... August 26, 2015 , ... MediVet Biologics, a ... US laboratory is to open in Manhattan, Kansas in early October, 2015. The ... growth of research and development through collaboration with researchers from Kansas State University’s ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes Research ... University of Miami Miller School of Medicine, announced ... trial to test for the first time a ... completed.  This FDA approved Phase I/II study builds ... and is an important first step toward the ...
Breaking Biology Technology:Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4
... 15 Senex Biotechnology, Inc. presented,today new results ... International,Conference on Alzheimer,s Disease Drug Discovery in New ... the identification of the first,drug candidates that block ... involved in Alzheimer,s disease, including: amyloid,precursor protein (APP); ...
... Oct. 15 The Liver Meeting is the premier,meeting ... latest,findings on new drugs, novel treatments, and the results ... Americans have some form of liver disease,and the diseases ... choices. There are now numerous treatments,for both hepatitis B ...
... Velcura Therapeutics, Inc.,has named Jeffrey N. Fellows, ... of successful regulatory experience, as Vice President,of Regulatory ... W. Long, PhD, said,"Jeff is a great addition ... for our clinical trials applications, regulatory compliance and,interactions ...
Cached Biology Technology:Senex Biotechnology Announces Presentation of Alzheimer's Disease Drug Discovery Effort 2Senex Biotechnology Announces Presentation of Alzheimer's Disease Drug Discovery Effort 3Velcura Therapeutics, Inc. Appoints Industry Executive to Lead Regulatory Affairs 2
... An N-nitroso-containing diabetogenic compound that acts ... pancreatic islets. An antibiotic effective against ... DNA strand breaks in pancreatic islet ... in H 2 O. RTECS LZ5775000, ...
Mouse monoclonal antibody to CDC2L5 - cell division cycle 2-like 5 (cholinesterase-related cell division controller)...
... The pACHLT-A-BFP Baculovirus Transfer Vector is a derivative ... the gene for blue fluorescent protein (BFP), followed ... site (MCS).,Foreign genes are expressed as BFP-6xHis fusion ... restriction enzyme,sites (EcoR I, Stu I, Sac I, ...
... of Br-dUTP results in a stronger signal ... fluorescein-labeled anti-BrdU antibody. Propidium iodide/RNase A ... counterstain the total DNA. Features and Benefits: ... detection than found by using biotin- or ...
Biology Products: