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Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial
Date:12/30/2008

d by duration of supplementation and single or combined antioxidant regimens."

In an accompanying editorial, Demetrius Albanes, M.D., of the National Cancer Institute, reviewed data from previous randomized controlled trials that examined supplement use and cancer incidence. He noted that while the trial data reported by Lin are negative with respect to lowering cancer risk, there is valuable information uncovered that should not be overlooked. There was a trend for a reduction in colon cancer with vitamin E supplementation, which has been observed in other studies. Additionally, beta carotene use was associated with a modest excess of lung cancer, which is consistent with previous reports.

"Null trials or those with unexpected outcomes should not, however, be viewed as failures; they have and will continue to shed light on the causes of cancer and help us discover the means for its prevention," the editorialist concludes.


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Contact: Caroline McNeil
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

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