Navigation Links
Vitamin P as a potential approach for the treatment of damaged motor neurons
Date:4/2/2013

Biologists from the Ruhr-Universitt Bochum have explored how to protect neurons that control movements from dying off. In the journal "Molecular and Cellular Neuroscience" they report that the molecule 7,8-Dihydroxyflavone, also known as vitamin P, ensures the survival of motor neurons in culture. It sends the survival signal on another path than the molecule Brain Derived Neurotrophic Factor (BDNF), which was previously considered a candidate for the treatment of motoneuron diseases or after spinal cord damage. "The Brain Derived Neurotrophic Factor only had a limited effect when tested on humans, and even had partially negative consequences", says Prof. Dr. Stefan Wiese from the RUB Work Group for Molecular Cell Biology. "Therefore we are looking for alternative ways to find new approaches for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis."

Same effect, different mode of action

In previous studies, researchers hypothesised that vitamin P is an analogue of BDNF and thus works in the same way. This theory has been disproved by the team led by Dr. Teresa Tsai and Prof. Stefan Wiese from the Group for Molecular Cell Biology and the Department of Cell Morphology and Molecular Neurobiology headed by Prof. Andreas Faissner. Both substances ensure that isolated motor neurons of the mouse survive in cell culture and grow new processes, but what exactly the molecules trigger at the protein level varies. BDNF activates two signalling pathways, the so-called MAP kinase and PI3K/AKT signal paths. Vitamin P on the other hand makes use only of the latter.

The dose is crucial

However, vitamin P only unfolded its positive effects on the motor neurons in a very small concentration range. "These results show how important an accurate determination of dose and effect is", says Prof. Wiese. An overdose of vitamin P reduced the survival effect, and over a certain amount, no more positive effects occurred at all. The researchers hope that vitamin P could have less negative side effects than BDNF. "It is easier to use, because vitamin P, in contrast to BDNF, can pass the blood-brain barrier and therefore does not have to be introduced into the cerebrospinal fluid using pumps like BDNF," says Wiese.


'/>"/>

Contact: Dr. Stefan Wiese
stefan.wiese@rub.de
49-234-322-2041
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Vitamin D benefits breathing in tuberculosis patients
2. Living in a sunny climate does not improve vitamin D levels in hip fracture patients
3. Folate and vitamin B12 reduce disabling schizophrenia symptoms in some patients
4. Organic tomatoes accumulate more vitamin C, sugars than conventionally grown fruit
5. Vitamin C is beneficial against the common cold
6. African-American, Caucasian women should take identical vitamin D doses
7. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
8. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
9. Supplements and cows milk play biggest roles in determining vitamin D levels in children
10. Low vitamin D levels in pregnancy associated with lower birth weights, pitt research finds
11. New review associates vitamin D with lower rates of tooth decay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:5/15/2017)... , ... May 15, 2017 , ... Tunnell Consulting ... a presentation of “The Key Role of Specifications in Process Validation,” at the ... . The event will bring together leaders from the pharmaceutical and biotech industries to ...
(Date:5/15/2017)... ... May 15, 2017 , ... Algenist ... Lift Contouring Cream, a gravity-shattering cream with a patented formula, clinically proven to ... bring the Advanced Lift Contouring Cream to our already innovative ELEVATE product line,” ...
(Date:5/15/2017)... -- IBM (NYSE: IBM ) scientists have developed ... molecules with the potential to efficiently reveal biomarkers ... complements the IBM Research,s "lab-on-a-chip" nanoDLD technology ... which may also contain biomarkers for disease detection. ... diamond shaped micropillars 1 to pre-stretch DNA ...
(Date:5/12/2017)... , May 12, 2017  Eli Lilly and Company ... galcanezumab, an investigational treatment for the prevention of ... in three Phase 3 studies (EVOLVE-1, EVOLVE-2 and ... of monthly migraine headache days compared to placebo ... robust results from these three studies bring us ...
Breaking Biology Technology: