Navigation Links
Vitamin E identified as potential weapon against obesity
Date:4/23/2013

BOSTON A potential new way to fight obesity-related illness has been uncovered, thanks to serendipitous research led by investigators at the Case Western Reserve University School of Medicine.

The collaborators, from Case Western Reserve University, the Cleveland Clinic Foundation and Cornell University, discovered the essential nutrient vitamin E can alleviate symptoms of liver disease brought on by obesity. "The implications of our findings could have a direct impact on the lives of the approximately 63 million Americans who are at potential risk for developing obesity-related liver disease in their lifetimes," says Danny Manor, an associate professor at the Case Western Reserve University School of Medicine.

On Wednesday, April 24, Manor and colleague Varsha Thakur will present the group's findings at the annual meeting of the American Society for Biochemistry and Molecular Biology, held in conjunction with the Experimental Biology 2013 meeting in Boston.

As is often the case in science, Manor's research team at Case Western stumbled upon the findings entirely by accident. While studying the effect of vitamin E deficiency on the central nervous system, "we used liver tissue to practice our surgical techniques," recalled Manor, an associate professor of nutrition and pharmacology. To the team's surprise, they realized that the mice were in fact in the advanced stages of nonalcoholic steatohepatitis. Known as NASH for short, it's a common complication of obesity characterized by fat accumulation, oxidative stress and inflammation in the liver. It is the most severe form of nonalcoholic fatty liver disease and is a major cause of tissue scarring known as cirrhosis that leads to liver failure and may progress to liver cancer.

An essential antioxidant, vitamin E had been shown by recent studies to alleviate some symptoms of NASH in human patients, suggesting that there is a link between adequate vitamin E levels and liver disease. To test this hypothesis, the team studied a mouse that was engineered to lack a protein that regulates the levels of vitamin E in the body. As expected, they observed increased oxidative stress, fat deposition and other signs of liver injury in the mice. Importantly, points out Manor, "supplementation with vitamin E averted the majority of NASH-related symptoms in these animals, confirming the relationship between vitamin E deficiency and liver disease."

The precise effects of vitamin E on health have previously been difficult to ascertain, though its antioxidative properties were suggested to offer some protection from a variety of well-known maladies, including heart disease, cancer and neurological diseases such as Alzheimer's and Lou Gehrig's disease (amyotrophic lateral sclerosis, or ALS).

"These findings may have a significant impact on public health," says Manor, "as the vast majority of adults in the United States do not consume the amount of vitamin E recommended by the National Institute of Medicine."

For adults, the recommended dietary allowance of vitamin E is 15 milligrams a day. Vegetable oils, nuts and seeds, leafy greens and fortified cereals commonly contain vitamin E.

"Simple and affordable dietary intervention may benefit people at risk for this debilitating disease," Manor says.

There is currently no treatment for NASH, making it one of the most common reasons for liver transplantation. Manor also points out that "NASH piggybacks on the two great epidemics of our time: obesity and Type 2 diabetes."

According to the Centers for Disease Control and Prevention, obesity affects more than one-third of adults and one-sixth of children in the U.S., while nearly one in 10 Americans today suffers from diabetes, rates that have been climbing over the past two decades. Thus, for Manor, the significance of his group's findings is not only the possibility that they will aid those who are currently sick but that they may also "affect many people who are presently healthy, but are at risk for becoming obese or diabetic in the future."

Moreover, Manor believes that his group's discovery will be key to determining the molecular details of NASH itself. "Right now, we really don't understand how NASH progresses from mild liver damage to severe liver failure," he said. "Our results will enable us to dissect the different steps in this progression, as well as study how oxidative stress affects liver function more generally, giving possible insights into other related disorders."


'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
713-471-4541
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Quit smoking? Vitamin E may give extra boost to heart health
2. Excess vitamin E intake not a health concern
3. Vitamin P as a potential approach for the treatment of damaged motor neurons
4. Vitamin D benefits breathing in tuberculosis patients
5. Living in a sunny climate does not improve vitamin D levels in hip fracture patients
6. Folate and vitamin B12 reduce disabling schizophrenia symptoms in some patients
7. Organic tomatoes accumulate more vitamin C, sugars than conventionally grown fruit
8. Vitamin C is beneficial against the common cold
9. African-American, Caucasian women should take identical vitamin D doses
10. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
11. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... , Feb. 5, 2016 ... of the "Global Facial Recognition Market ... --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ... Market 2016-2020" report to their offering. ... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the addition of ...
(Date:2/3/2016)... 3, 2016 Vigilant Solutions announces today that ... Missouri solved two recent hit-and-run ... data from Vigilant Solutions. Brian Wenberg ... the victim was walking out of a convenience store and witnessed an elderly ... his vehicle, striking his vehicle and leaving the scene.  ...
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... expansion to their comprehensive training and support program, Sonalink™ remote monitoring. The inaugural ... procedures performed on Friday, February 5th, connecting Dr. Samuel Peretsman to a HIFU ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... now available on Microsoft Azure. On Azure, Arvados provides capabilities for managing and ... clear demand for Microsoft Azure from major institutions collecting and analyzing genomic data,” ...
(Date:2/10/2016)... CA (PRWEB) , ... February 10, 2016 , ... Cenna ... agents for the treatment of Alzheimer’s disease, announced today it has been selected to ... 18th at the Breakers in Palm Beach, Florida. The purpose of the Forum ...
(Date:2/9/2016)... ... 2016 , ... With a presidential election in November and the future of ... together over 500 top healthcare leaders for a night and day of debates and ... MBA students of the University of Pennsylvania’s Wharton School, will be held February 18 ...
Breaking Biology Technology: