Navigation Links
Vitamin D supplements do not improve cholesterol as previous research suggested

Vitamin D has been touted for its beneficial effects on a range of human systems, from enhancing bone health to reducing the risk of developing certain cancers. But it does not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. A team of scientists has shown that, at least in the short term, cholesterol levels did not improve when volunteers with vitamin D deficiency received mega-doses of vitamin D. The finding is published in the journal Arteriosclerosis, Thrombosis and Vascular Biology.

The researchers, led by Manish Ponda, an assistant professor of clinical investigation in Jan Breslow's Laboratory of Biochemical Genetics and Metabolism, studied 151 people with vitamin D deficiency. The study participants were given either 50,000 internationals units of vitamin D3 or a placebo weekly for eight weeks. Participants' cholesterol levels were measured before and after treatment.

Correcting vitamin D deficiencies with high doses of oral vitamin D supplements did not change cholesterol levels, Ponda and his colleagues found, despite effectively increasing vitamin D to recommended levels. Vitamin D levels nearly tripled in the group that received supplements, but were unchanged in the placebo group.

"Our study challenges the notion that replenishing vitamin D improves cholesterol," says Ponda. "In fact, a biologic response to vitamin D was correlated with an increase in LDL cholesterol."

Ponda and his colleagues also tested the effect of vitamin D supplementation on lipoprotein particle size and number, biomarkers of cholesterol not typically measured in clinical practice, and found no change in response to increases in vitamin D.

These clinical trial results confirm those from a recent data mining study, published in July in the journal Circulation, conducted by the Breslow lab in collaboration with scientists at Quest Diagnostics. In that study, the researchers examined a de-identified dataset for 8,592 patients and showed that raising vitamin D levels from deficient to optimal levels had no statistically significant effect on LDL (bad) cholesterol, or triglycerides. Increasing vitamin D had a small, but clinically minimal impact on total and HDL (good) cholesterol. Both studies were supported by a Clinical and Translational Science Award from the National Center for Advancing Translational Science.

"This study raises questions about the use of vitamin D supplements to improve cholesterol," Ponda says. "Longer-term studies on the impact of vitamin D supplementation are needed to make stronger recommendations."


Contact: Joseph Bonner
Rockefeller University

Related biology news :

1. High doses of Vitamin D help tuberculosis patients recover more quickly
2. Vitamin B12 deficiency: Tracing the causes
3. Vitamin B12 deficiency: Tracking the genetic causes
4. Vitamin D supplementation can decrease risk of respiratory infections in children
5. Iron, vitamins could affect physical fitness in adolescents
6. Lower vitamin D could increase risk of dying, especially for frail, older adults
7. Scientists confirm existence of vitamin deserts in the ocean
8. Obesity plus low vitamin D may add up to a greater risk of diabetes
9. Low vitamin D levels linked to weight gain in some older women
10. Link between vitamin C and twins can increase seed production in crops
11. 15th Vitamin D Workshop begins tomorrow
Post Your Comments:
(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... They call ... complex biological network, a depiction of a system of linkages and connections so ... PhD, associate professor of computer science at Worcester Polytechnic Institute (WPI) and director ...
(Date:10/12/2017)... ... 2017 , ... DuPont Pioneer and recently formed CasZyme, a ... a multiyear collaboration to identify and characterize novel CRISPR-Cas nucleases. The goal of ... across all applications. , Under the terms of the agreement, Pioneer will provide ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... Wound Market with the addition of its newest module, US Hemostats & Sealants. ... for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic sealants used ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... genomics analysis platform specifically designed for life science researchers to analyze and ... researcher Rosalind Franklin, who made a major contribution to the discovery of ...
Breaking Biology Technology: