Navigation Links
Vitamin D supplements do not improve cholesterol as previous research suggested
Date:9/4/2012

Vitamin D has been touted for its beneficial effects on a range of human systems, from enhancing bone health to reducing the risk of developing certain cancers. But it does not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. A team of scientists has shown that, at least in the short term, cholesterol levels did not improve when volunteers with vitamin D deficiency received mega-doses of vitamin D. The finding is published in the journal Arteriosclerosis, Thrombosis and Vascular Biology.

The researchers, led by Manish Ponda, an assistant professor of clinical investigation in Jan Breslow's Laboratory of Biochemical Genetics and Metabolism, studied 151 people with vitamin D deficiency. The study participants were given either 50,000 internationals units of vitamin D3 or a placebo weekly for eight weeks. Participants' cholesterol levels were measured before and after treatment.

Correcting vitamin D deficiencies with high doses of oral vitamin D supplements did not change cholesterol levels, Ponda and his colleagues found, despite effectively increasing vitamin D to recommended levels. Vitamin D levels nearly tripled in the group that received supplements, but were unchanged in the placebo group.

"Our study challenges the notion that replenishing vitamin D improves cholesterol," says Ponda. "In fact, a biologic response to vitamin D was correlated with an increase in LDL cholesterol."

Ponda and his colleagues also tested the effect of vitamin D supplementation on lipoprotein particle size and number, biomarkers of cholesterol not typically measured in clinical practice, and found no change in response to increases in vitamin D.

These clinical trial results confirm those from a recent data mining study, published in July in the journal Circulation, conducted by the Breslow lab in collaboration with scientists at Quest Diagnostics. In that study, the researchers examined a de-identified dataset for 8,592 patients and showed that raising vitamin D levels from deficient to optimal levels had no statistically significant effect on LDL (bad) cholesterol, or triglycerides. Increasing vitamin D had a small, but clinically minimal impact on total and HDL (good) cholesterol. Both studies were supported by a Clinical and Translational Science Award from the National Center for Advancing Translational Science.

"This study raises questions about the use of vitamin D supplements to improve cholesterol," Ponda says. "Longer-term studies on the impact of vitamin D supplementation are needed to make stronger recommendations."


'/>"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
Source:Eurekalert

Related biology news :

1. High doses of Vitamin D help tuberculosis patients recover more quickly
2. Vitamin B12 deficiency: Tracing the causes
3. Vitamin B12 deficiency: Tracking the genetic causes
4. Vitamin D supplementation can decrease risk of respiratory infections in children
5. Iron, vitamins could affect physical fitness in adolescents
6. Lower vitamin D could increase risk of dying, especially for frail, older adults
7. Scientists confirm existence of vitamin deserts in the ocean
8. Obesity plus low vitamin D may add up to a greater risk of diabetes
9. Low vitamin D levels linked to weight gain in some older women
10. Link between vitamin C and twins can increase seed production in crops
11. 15th Vitamin D Workshop begins tomorrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... -- The American College of Medical Genetics and Genomics was once ... one of the fastest-growing trade shows during the Fastest 50 ... Las Vegas . Winners ... each of the following categories: net square feet of paid ... The 2015 ACMG Annual Meeting was ranked 23 out of ...
(Date:6/22/2016)... On Monday, the Department of Homeland Security ... solutions for the Biometric Exit Program. The Request for ... (CBP), explains that CBP intends to add biometrics to ... United States , in order to deter visa ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the ... major shareholders, Clean Technology Fund I, LP and Clean ... based venture capital funds which together hold approximately ... fully diluted, as converted basis), that they have entered ... equity holdings in Biorem to TUS Holdings Co. Ltd. ...
(Date:6/27/2016)... ... 27, 2016 , ... Rolf K. Hoffmann, former senior vice ... University of North Carolina Kenan-Flagler Business School effective June 27. , ... with a focus on the school’s international efforts, leading classes and participating in ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
Breaking Biology Technology: