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Vitamin D status not predicted by surrogate markers, UB researchers find
Date:4/20/2010

factors, such as genetics or other variables not measured or not yet known, may help to better predict an individual's blood vitamin D level.

"This information is important, nevertheless, because it tells researchers that less weight should be given to previous studies that used proxy measures for vitamin D instead of blood measures to predict risk of cancer outcomes."

The investigation is based on blood samples from 3,055 postmenopausal women who took part in the Women's Health Initiative (WHI) Calcium plus Vitamin D clinical trial conducted from 1995-2000 or in the original WHI trial, which took place from 1993-98.

Actual vitamin D data from the samples was compared to surrogate markers for vitamin D status -- latitude of residence, annual sunlight at particular latitudes, and how much vitamin D participants consumed from foods and supplements.

Even after considering latitude, season of the year when blood samples were taken, regional sunlight exposure, age, race-ethnicity and other lifestyle factors such as waist circumference and physical activity, there still were differences in serum vitamin D levels between people that could not be explained, results showed.

"We learned that using this data still doesn't allow us to very accurately predict an individual's blood vitamin D status," says Millen.

"However, our study did not have very detailed data on individual sun exposure, so if we had had that information, perhaps we might have been able to more accurately predict an individual's vitamin D blood levels. We assume, though, based on other studies similar to ours, that even with measures of sun exposure, a predictive model still wouldn't be very valid."

Millen's advice? "When evaluating the information you hear in the news, be aware that relationships between location of residence and a disease outcome, or even studies that looked at just vitamin D intake from foods and supplements (without consi
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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert

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